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Neuroprotection
Home > Research > Neuroprotection
Mechanisms for promoting cell suvival and therapies for acute neuroprotection after injury are studied by this interdisciplinary group of CBSCR investigators.
Featured Recent Discovery
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Drs. Ankeny, Sanders, Popovich and coworkers have shown that experimental spinal cord injury elicits chronic activation of a B cell-dependent autoimmune response.
In this novel study, high levels of anti-DNA antibodies were detected in spinal cord injured rats with a pattern that is similar to that seen in systemic lupus erythematosus. This is the first report that spinal cord injury can cause a clear dysregulation of B-cell function. Link |
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Recent Publications |
Ankeny DP, Lucin KM, Sanders VM, McGaughy VM, Popovich PG. Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis. J Neurochem. 2006 Nov;99(4):1073-87. Link
Godbout JP, Johnson RW. Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin. 2006 Aug;24(3):521-38. Link
Ghafourifar P, Sen CK. Mitochondrial nitric oxide synthase. Front Biosci. 2007 Jan 1;12:1072-8. Link
Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani S, Sen CK, Marsh CB. The Role of the NADPH Oxidase Complex, p38 MAPK, and Akt in Regulating Human Monocyte/Macrophage Survival. Am J Respir Cell Mol Biol. 2007 Jan;36(1):68-77. Link
Lin CL, Winardi W, Jeng AY, Kwan AL. Endothelin-converting enzyme inhibitors for the treatment of subarachnoid hemorrhage-induced vasospasm. Neurol Res. 2006 Oct;28(7):721-9. Link
Tian G, Lai L, Guo H, Lin Y, Butchback MR, Chang Y, Lin CL. Translational control of glial glutamate transporter EEAT2 expression. J. Biol Chem. 2007 Jan 19;282(3):1727-37. Link | |
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