David Padgett Research Interests

Molecular regulation of cytokine gene expression by steroid hormones and neuroendocrine control of wound healing and inflammation

Publications
Maeda K, Burton GF, Padgett DA, Conrad DH, Huff TF, Masuda A, Szakal AK, Tew JG. (1992) Murine Follicular Dendritic Cells and Low Affinity Fc-Receptors for IGE (Fc,RII), The Journal of Immunology 148:2340-2347.

Loria RM, Padgett DA. (1992) Androstenediol regulates systemic resistance to lethal infectons in mice. Archives of Virology. 127:103-115.

Padgett DA, Loria RM. (1994) In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol. Journal of Immunology. 153:1544-1552.

Padgett DA, Loria RM, Sheridan JF. (1997) Endocrine regulation of the immune response to influenza A virus infection with a metabolite of deydroepiandrosterone -- androstenediol. Journal of Neuroimmunology. 78:203-211.
Padgett DA, Loria RM. (1998) Effects of dehydroepiandrosterone, androstenediol, and androstenetriol on TNF-", IL-1, and IL-6 secretion from murine macrophages in vitro. Journal of Neuroimmunology, 84: 61-68.

Padgett DA, Marucha PT, Sheridan JF. (1998) Neuroendocrine effects on wound healing in SKH-1 female mice. Brain, Behavior, and Immunity. 12: 64-73.

Padgett DA, Sheridan JF, Dorne J, Berntson G, Candelora J, Glaser R. (1998) Social Stress and the reactivation of latent herpes virus-type 1. Proceedings of the National Academy of Sciences of the United States of America. 95: 7231-7235.

Padgett DA, MacCallum RC, Sheridan JF. (1998) Stress exacerbates age-related decrements in the immune response to an experimental influenza viral infection. Journal of Gerontology: Biological Sciences. 53A: B347-B353.

Padgett DA, Sheridan JF. (1999) Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection. Journal of Neuroimmunology. 98:121-129.

Padgett DA, MacCallum RC, Loria RM, Sheridan JF. Restoration of the age-associated decline in the antibody response to an influenza vaccine by androstenediol-sulfate. Journal of Gerontology: Biological Sciences. Accepted for Publication; Jan, 2000.

Padgett DA, MacCallum RC, Loria RM, Sheridan JF. (2000) Androstenediol-induced restoration of responsiveness to influenza vaccination in mice.  Journal of Gerontology: Biological Sciences. 55A: B1-B7.

Stark JL, Avitsur R, Hunzeker J, Padgett DA, Sheridan JF. (2002)  Interleukin-6 and the development of social disruption-induced glucocorticoid resistance. Journal of Neuroimmunology 124: 9-15.

Padgett DA, Glaser R, (2003) How Stress Influences the Immune Response. Trends in Immunology. 24(8):444-448.

Bailey MT, Avitsur R, Engler H, Padgett DA, Sheridan JF. (2004) Physical defeat reduces the sensitivity of murine splenocytes to the suppressive effects of corticosterone.  Brain, Behavior and Immunity 18(5): 416-424.

Padgett DA, Hotchkiss AK, Pyter LM, Nelson RJ, Yang E, Yeh P-E, Litsky M, Williams M, Glaser R. (2004) Epstein-Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice. Journal of Medical Virology 74:442-448.

Tseng RJ, Padgett DA, Dhabhar FS, Engler H, Sheridan JF. (2005) Stress-induced modulation of NK activity during influenza viral infection: Role of glucocorticoids and opioids. Brain, Behavior and Immunity  19(2):153-164

Lowder T, Padgett DA, Woods JA. (2005) Moderate exercise protects mice from death due to influenza virus.  Brain, Behavior and Immunity 19(5):377-380.

Glaser R, Litsky ML, Padgett DA, Baiocchi RA, Yang EV,  Chen M, Yeh P, Green-Church KB, Caligiuri MA, Williams MV. (2006)  EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease.  Virology 346:205-218.

Head CC, Farrow MJ, Sheridan JF, Padgett DA (2006) Androstenediol Reduces the Anti-Inflammatory Effects of Restraint Stress during Wound Healing.  Brain, Behavior and Immunity. 50:590-596.

Bailey MT, Padgett DA, Sheridan JF. (2006) Stress-Induced Modulation Of Innate Resistance And Adaptive Immunity To Influenza Viral Infection. In Ader, R., Dantzer, R., Glaser, R., Heijnen, C., Irwin, M., Padgett, D., & Sheridan, J. (Eds.), Psychoneuroimmunology, Fourth Edition. Academic Press: Boston, 2006.

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