Virginia Sanders

Research Interests:
Regulation of CD4+ T and B lymphocyte activity by the binding of the sympathetic neurotransmitter norepinephrine to the beta-2-adrenergic receptor. Cellular, biochemical, and molecular studies are performed to determine mechanisms by which the beta-2-adrenergic receptor is differentially expressed on CD4+ T cell subsets, as well as mechanisms by which stimulation of the receptor regulates naive CD4+ T cell differentiation, effector cytokine production, and B cell antibody production.

Publications:
Sanders, V.M., Baker, R.A., Ramer-Quinn, D.S., Kasprowicz, D.J., Fuchs, B.A., and
Street, N.E. 1997. Differential expression of the beta-2-adrenergic receptor by Th1 and
Th2 clones: Implications for cytokine production and B cell help. J. Immunol.,158:
4200-4210.

Kohm, A. and Sanders, V.M. 1999. Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo. J. Immunol. 162:5299-5308.

Kasprowicz, D.J., Kohm, A.P., Berton, M. Chruscinski, A.J., Kobilka, B.K., Sharpe, A., and Sanders, V.M. 2000. Stimulation Of The B Cell Receptor, CD86 (B7-2), and The Beta-2-Adrenergic Receptor Intrinsically Modulates The Level Of IgG1 And IgE Produced Per B Cell. J. Immunol., 165: 680-690.

Kohm, A.P. and Sanders, V.M. 2000. Norepinephrine: a messenger from the brain to the immune system. Immunology Today, 21: 539-542.

Swanson, M.A., Lee, W.T., and Sanders, V.M. 2001. IFN-g Production by Th1 Cells Generated From Naive CD4+ T cells Exposed to Norepinephrine. J. Immunol., 166:232-240.

Kohm, A.P. and Sanders, V.M. 2001. Norepinephrine and beta-2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol. Rev., 53:487-525.

Kohm, A.P., Mozaffarian, A., and Sanders, V.M. 2002. B cell receptor- and beta-2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells. J. Immunol., 168: 6314-22.

Sanders, V.M. and Straub, R.H. 2002. Norepinephrine, Beta-Adrenergic Receptors, and Immunity. Brain, Behavior & Immunity, 16:290-332.

Podojil, J. and Sanders, V.M. 2003. Mature IgG1 transcription is regulated by CD86 and beta-2-adrenergic receptor stimulation on a B cell. J. Immunol., 170:5143-5151.

Podojil, J., Kin, N. and Sanders, V.M. 2004. CD86 and beta-2-adrenergic receptor signaling pathways in a B cell increase Oct-2/OCA-B expression. J. Biol. Chem., 279:23394-404.

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