John Sheridan Research Interests

Viral immunology, regulation of T cell responses during viral infection, cytokine and chemokine gene expression during infection (influenza, herpes simplex and coxsackie viruses).

Neuroendocrine-immune interactions; stress-induced modulation of anti-viral immune responses and viral pathogenesis.

Aging and the immune response to viral infection.

Aging and gene expression during wound healing. Patterns and kinetics of gene expression for cytokines, chemokines and growth factors during cutaneous wound healing.

Research Summary
The laboratory uses cellular and molecular techniques to study viral pathogenesis, anti-viral immunity and wound healing. An integrative physiological approach is used to study interactions among the nervous, endocrine and immune systems. Animal models of experiment viral infections (including influenza, herpes simplex and coxsackie viruses) have been adapted to study the effect of neuroendocrine responses on cytokine and chemokine gene expression. In addition, the effects of age and stress on gene expression during infection and wound healing are currently being studied in humans and in animal models.

Publications
Padgett, D.A., Marucha, P.T., and Sheridan, J.F. Restraint stress slows cutaneous wound healing in mice. Brain, Behavior and Immunity 12:64-73, 1998.

Padgett, D.A., Sheridan, J.F., Dorne, J., Bernston, G.G., Candelora, J., and Glaser, R. Social stress and the reactivation of latent herpes simplex virus-type 1. Proceedings of the National Academy of Science USA 95:7231-7235, 1998.

Padgett, D.A. and Sheridan, J.F. Stress exacerbates age-related decrements in the immune response to an experimental influenza viral infection. Journal of Gerontology: Biological Sciences 53A: B347-353, 1998.

Sheridan, J.F., Dobbs, C., Jung, J., Chu, X., Konstantinos, A., Padgett, D.A., and Glaser, R. Stress-induced neuroendocrine modulation of viral pathogenesis and immunity. Annals of the New York Academy of Science 840: 803-808, 1998.

Sheridan, J.F. Stress-induced modulation of anti-viral immunity. Brain, Behavior and Immunity 12:1-6, 1998.

Ghoshal, K., Wang, Y., Sheridan, J.F. and Jacob, S. Metallothionein induction in response to restraint stress: Transcriptional control, adaptation to stress and role of glucocorticoid. J. Biological Chemistry 273:27904-27910, 1998.

Padgett, D.A. and Sheridan, J.F. Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection. J. Neuroimmunology, 98:121-129, 1999.

Jacob, S., Ghoshal, K., and Sheridan, J.F. Induction of metallothionein by stress and its molecular mechanisms. Gene Expression 7:301-310, 1999.

Bonneau, R., Padgett, D.A., and Sheridan, J.F. Psychoneuroimmune interactions in infectious disease: Studies in animals. In: Psychoneuroimmunology. Ader, R. et al., Editors. Academic Press, San Diego, CA, In press, 2000.

Cacioppo, J.T., Bernston, G.G., Sheridan, J.F., and McClintock, M.K. Multi-level integrative analysis of human behavior: the complementing nature of social and biological approaches. Psych. Bulletin, In press, 2000.

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