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Caroline Whitacre Research Interests
Spinal cord neuropathology in experimental autoimmune encephalomyelitis:
Modulation by oral administration of myelin basic protein.
Research Summary
The laboratory uses cellular and molecular approaches to devise
therapeutic regimens for multiple sclerosis focusing on the animal
model, experimental autoimmune encephalomyelitis (EAE). The primary
focus of research is to understand the mechanisms underlying disease
suppression following the oral administration of antigen (oral
tolerance). The laboratory also studies the effects of stress
and CNS trauma on the immune system.
Publications
Oral Tolerance in Experimental Autoimmune Encephalomyelitis: Evidence
for Clonal Anergy. C.C. Whitacre, D.M. Bitar, C.G. Orosz and I.E.
Gienapp. Journal of Immunology 147: 2155-2163, 1991.
Suppression of Experimental Autoimmune Encephalomyelitis (EAE)
by Restraint Stress: Sex Differences. A.C. Griffin, W.D. Lo, A.C.
Wolny, and C.C. Whitacre. J. Neuroimmunol. 44:103-116, 1993.
Exquisite Peptide Specificity of Oral Tolerance in Experimental
Autoimmune Encephalomyelitis. N. Javed, I. Gienapp, K. Cox, and
C. Whitacre. J. Immunology 155:1599-1605, 1995.
Suppression of Murine Chronic Relapsing Experimental Autoimmune
Encephalomyelitis by Oral Administration of Myelin Basic Protein.
A.L. Meyer, J.M. Benson, I.E. Gienapp, K.L. Cox, and C.C. Whitacre.
Journal of Immunology, in press.
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