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Luanne Hall-Stoodley, PhD


Luanne Hall-Stoodley Picture.jpg




Research Associate Professor, Department of Microbial Infection and Immunity

Member, Center for Microbial Interface Biology

Contact information:​
714 Biomedical Research Tower (BRT)
460W 12th Ave., Columbus OH 43210
Phone: (614) 292-7851​

Luanne.Hall-Stoodley@osumc.edu

Publications

Research Interests

The Hall-Stoodley lab focuses on mechanisms of pathogen persistence in respiratory infections, which constitute an enormous burden on global health. Biofilm development (adherence and aggregation of microorganisms to host epithelia or to medical implants) is one mechanism pathogens use to enhance resistance to host innate immune defenses and antimicrobial agents. Thus, biofilm development promotes microbial persistence and biofilm-associated infections (BAI) are chronic infections because antimicrobial therapy treats single bacterial cells more effectively than adherent aggregated cells.

The primary focus of the Hall-Stoodley lab is on phenotypic changes in respiratory pathogens resulting from adherence and aggregation and how these changes impact host innate immunity. By better understanding the mechanisms of bacterial persistent phenotypes, we will better understand ways to decrease the global burden of respiratory disease. Specifically we are interested in adherence and biofilm development in Streptococcus pneumonia and Haemophilus Influenzae, both associated with chronic otitis media, opportunistic nontuberculosis mycobacterial infections which affect people with cystic fibrosis, and in Mycobacterium tuberculosis.

Improved diagnosis of BAI is also needed. The investigation of biofilms in clinical samples includes direct visualization of biofilms in tissues and on medical implants using viability staining, fluorescent in situ hybridization (FISH) and confocal imaging, alongside culture, qPCR and high resolution imaging. Collectively these comprise a series of ex vivo assays that better pinpoint a biofilm etiology. These assays also help demonstrate the co-localization of specific pathogens with host cells facilitating a better understanding of BAI pathogenesis. These assays can also help assess responses to therapeutic agents or novel treatments.

 

Laboratory Personnel

 

TBD
Research Assistant
760 BRT
292-7871
TBD
Jennifer Carstens
Staff Employee
760 BRT
292-7871
Jennifer.Carstens