Muthusamy, Natarajan

Natarajan Muthusamy, D.V.M., Ph.D.

Visiting Assistant Professor
Department of Hematology/Oncology

Joint Appointment
Department of Molecular Virology, Immunology and Medical Genetics and Veterinary Biosciences 

Contact Information:

Office: 614-293-7406

Fax: 614-293-9189

Address:

1132C, James Cancer Hospital

300, W.10th Ave

Columbus, OH 43210

Email: raj.muthusamy@osumc.edu

Research interest:

B cell Leukemia, B and T Lymphocyte development, B cells and autoimmunity

Research summary:

We have identified CREB/ATF and Ets family of transcription factors in regulation of B cell growth and survival using transgenic and gene targeted mouse models. Our current research is focused on translational research aimed at defining the role of the CREB and Ets family of transcription factors in human leukemia with emphasis on devising therapeutic strategies aimed at targeted intervention of signaling events imparting resistance to apoptosis in leukemia.

Selected publications list:

1.  Chen, HC. Byrd, JC and Muthusamy N. (2005)Trangenic mice reveal a role for Cyclic AMP response element binding proteins in multiple stages of B cell development, maturation and apoptosis. Journal of Immunology (in press)

2.   Frissora F, Chen HC, Durbin J, Bondada S and Muthusamy N. (2003) IFN-gamma-mediated inhibition of antigen receptor-induced B cell proliferation and CREB-1 binding activity requires STAT-1 transcription factor. Eur J Immunol.  33(4):907-12.

3.   Muthusamy N, Park do J, Rho HW, Rhee SG, Subbarao B (2003). Impaired antigen receptor induced calcium mobilization in a phospholipase C-gamma1 deficient B cell line. Immunol Lett. 90:203-7.

4.  Chen HC, Frissora F, Durbin JE, Muthusamy N (2003). Activation induced differential regulation of stem cell antigen-1 (Ly-6A/E)  expression in murine B cells. Cell Immunol. 225:42-52.

5.  Muthusamy N, Leiden JM.  A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement. J Biol Chem.  273:22841-7.