Glaser, Ronald

Ronald Glaser, Ph.D.

Professor
Department of Molecular Virology, Immunology and Medical Genetics

Director, Institute for Behavioral Medicine Research

Joint Appointment
Department of Internal Medicine

Office:
2175 Graves Hall
333 West 10th Avenue
Columbus, Oh. 43210
Ph. (614) 292-5526
E-Mail: glaser.l@osu.edu

Laboratory:
2187 Graves Hall
333 West 10th Avenue
Columbus, Oh. 43210
Ph. (614) 292-0364

Research interest:
Tumor virology/stress and immunology

Research summary:
Dr. Glaser has been involved in the cell biology, molecular biology, and immunology of EBV and cancer for 37 years.  In 1982, Dr. Glaser started a collaboration with Dr. Kiecolt-Glaser and established a program combining behavior with the Virology and Cellular Immunology Laboratory in order to study the consequences of commonplace stressful events on the interactions among the CNS, endocrine, and immune systems.  This line of research has also allowed Dr. Glaser to continue his studies of EBV latency from a clinical perspective.  Dr. Glaser has been recognized as one of the World's Most Cited Authors comprised of less than one-half of one percent of all publishing researchers.  In 2004, he was elected as an AAAS fellow and served as President of the Psychneuroimmunology Research Society.  Dr. Glaser has been the Principal Investigator on three Program Project Grants and the Center grant in the field of Psychoneuroimmunology and the PI on an NIH post-doctoral training grant also in this area.  Many of the faculty involved in all three Program Project Grants, the Center grant and the Training grant are part of the training faculty.

Selected Publications:
Burleson, M.H., Poehlmann, K.M., Hawkley, L.C., Ernst, J.M., Berntson, G.G., Malarkey, W.B., Kiecolt-Glaser, J.K., Glaser, R., and Cacioppo, J.T. – Neuroendocrine and cardiovascular reactivity to stress in mid-aged and  older women: Long-term temporal consistency of individual differences.  Psychophysiology, 40: 358-369, 2003

Kiecolt-Glaser, Janice K; Bane, Cynthia; Glaser, Ronald; Malarkey, William B. – Love, marriage, and divorce:   newlyweds' stress hormones foreshadow relationship changes.  J Consult Clin Psychol 71(1): 176-88, 2003

Yang, E.V., and Glaser, R. – Stress-induced immunomodulation:  Implications for tumorigenesis.  Brain, Behavior, and Immunity, 17:s37-40, 2003.

Glaser, R., Robles, T., Sheridan, J., Malarkey, W., Kiecolt-Glaser, J.K. - Mild depressive symptoms are  Associated with amplified and prolonged inflammatory responses following influenza vaccination in older adults.  Archives of General Psychiatry 60: 1009-1014, 2003.

Padgett, David A. and Glaser, R – How stress influences the immune response.  Trends in Immunology 24(8):444-448, 2003.

Kiecolt-Glaser, Janice K., Preacher, Kristopher J., MacCallum, Robert C., Atkinson, Cathie, Malarkey, William B., and Glaser, Ronald – Chronic Stress and age-related increases in the proinflammatory cytokine, Interleukin-6. PNAS 100(15): 9090-9095, 2003.

Heffner, K. L., Kiecolt-Glaser, J. K., Loving, T.J., Glaser, R., & Malarkey, W. B. –Spousal support satisfaction as a modifier of psychological responses to marital conflict in younger and older couples. Journal of Behavioral Medicine, 27:233-254, 2004.

Loving, T. J., Heffner, K. L., Kiecolt-Glaser, J. K., Glaser, R., & Malarkey, W. B. Stress hormone changes and     marital conflict: Spouses’ relative power makes a difference. Journal of Marriage and Family, 66:595-612, 2004.

Padgett, D.A., Hotchkiss, A.K., Pyter, L.M., Nelson, R.J., Yang, E.V., Yeh, P-E, Litsky, M.L., Williams, M.V., and Glaser, R. - Epstein-Barr Virus-Encoded dUTPase Modulates Immune Function and Induces Sickness Behavior in Mice, Journal of Medical Virology, 74:442-448, 2004.

Andersen, B.L., Farrar, W.B., Golden-Kreutz, D.M., Glaser, R., Emery, C.F., Crespin, T.R., Shapiro, C.L., and Carson, W.E.—Psychological, behavioral, and immune changes following a psychological intervention:  A clinical trial, Journal of Clinical Oncology 22(17): 3570- 3580, 2004. 

Glaser, R. –Stress-Associated immune dysregulation and its importance for human health:  a personal history of   psychoneuroimmunology, Brain, Behavior and Immunity, 19(1): 3-11, 2005. 

Glaser, R., Padgett, D.A., Litsky, M.L., Baiocchi, R.A., Yang, E.V., Chen, M., Yeh, P-E, Klimas, N.G., Marshall, G.D., Whiteside, T., Herberman, R., Kiecolt-Glaser, J.K., and Williams, M.V. - Stress-associated changes in the steady state expression of latent Epstein-Barr Virus:  Implications for Chronic Fatigue Syndrome and Cancer, Brain, Behavior and Immunity, 19(2)91-103, 2005.

Glaser, R. and Kiecolt-Glaser, J.K. – Stress-Induced Immune Dysfunction:  Implications for Health, Nature Reviews Immunology, 5:10-18, 2005.

Glaser, R., Kiecolt-Glaser–Stress Damages Immune System and Health. Discovery Medicine 5(26):165-169, 2005.

Robles, T.F., Glaser, R., and Kiecolt-Glaser, J.K.—Out of Balance:  A new look at stress, depression and immunity, Invited Review, Current Directions in Psychological Science, 14:111-115, 2005. 

Kiecolt-Galser, J.K., Loving, T., Stowell, J., Malarkey, W., Lemeshow, S., Dickinson, S., Glaser, R.—Hostile Martial Interactions Influence Proinflammatory Cytokine Production and Wound Healing, Archives of General Psychiatry, in press.

Emery, C.F., Kiecolt-Glaser, J.K., Glaser, R., Malarkey, W.B., Frid, D.J. – Exercise accelerates wound healing     among healthy older adults: A preliminary investigation.  Journal of Gerontology, in press.

McGuire, L., Heffner, K., Glaser, R., Needleman, B., Malarkey, W., Dickinson, S., Lemeshow, S., Cook, C., Muscarella, P., Melvin, S., Ellison, C., Kiecolt-Glaser, J.K.-Pain and Wound Healing in Surgical Patients, Pain, in press.

Roy, S., Khanna, S., Yeh, P.-E., Rink, C., Malarkey, W. B., Kiecolt-Glaser, J. K., Laskowski, B., Glaser, R., & Sen, C. K. Wound site neutrophil transcriptome in response to psychological stress in young men. Gene Expression, in press. 

Kiecolt-Glaser, J.K., Malarkey, W.B., MacCallum, R.C., Cacioppo, J.T., & Glaser, R. - Longitudinal changes in   marital satisfaction, cellular immunity, and health in newlyweds.  Psychosomatic Medicine, submitted.

Loving, T.J., Heffner, K.L., Kiecolt-Glaser, J.K., Malarkey, W.B., and Glaser, R. – Marital insecurity and cellular immunological alterations.  Personal Relationships, submitted.

Yang, E.V., Heffner, K., Yeh, P-E., Kiecolt-Glaser, J.K., Glaser, R. – Stress-Associated Changes in Matrix Metalloproteinases and Cytokines During the Early Phases of Wound Healing, BBI, submitted.

Jewell, S.D., Lehman, A., Lemeshow, S., Yeh, P-E., Jones, S., Chen, M., Yang, E.V., Lambert, D., Suster, S., Glaser, R. – Molecular Markers Predicting Multiple Basal Cell Carcinoma, submitted.

Glaser, R., Litsky, M., Padgett, D., Baiocchi, R., Yang, E., Chen, M., Yeh, P-E., Caligiuri, M, Williams, M.V. –EBV-endoded dUTPase induces immune dysregulation.  Virology, in revision.