Shaw, James
James E. Shaw, Ph.D.
Assistant Professor
Department of Molecular Virology, Immunology and Medical Genetics
Contact Information: Office:
2194 Graves Hall
333 W. 10th Avenue
Columbus, Oh. 43210
Ph. (614) 292-7854
E-Mail: shaw.8@osu.edu
Laboratory:
2060 Graves Hall
333 W. 10th Avenue
Columbus, Oh. 43210
Ph. (614) 292-7854
Research Interests:
Herpesvirus (EBV and HHV8) immune-escape mechanisms; herpesvirus alteration of MHC expression; human lymphoma cell autocrine growth mechanisms.
Research Summary:
We have associated the human gammaherpesviruses EBV and HHV8 with MHC class II inhibition in Primary Effusion Lymphoma (PEL) and Burkitt's lymphoma (BL) cells. Our focus is to establish the mechanism of MHC class II inhibition using gammaherpesvirus-infected cell lines.
Selected publications:
Shaw, J.E., Knisley, L., Severson, B.Rahill and R.W. Lang, Establishment of AIDS-related primary-effusion lymphoma (PEL) cell lines that proliferate continuously without serum. Journal of Virological Methods. 94, 137-146. 2001.
Shaw, J.E. and R. Lang, Lymphoid Cell-Growth Hormone Interactions: A Serum-Free Model. In Vitro Cellular and Developmental Biology. 34, 604-606. 1998.
Lytras, A., N. Quan, M.E. Vrontakis, J.E. Shaw, P.A. Cattini, and H.G. Friesen. Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line. Endocrinology 132:620-628, 1993
Baglia, L.A., D. Cruz, and J.E. Shaw. Production of immunoreactive forms of growth hormone by the Burkitt tumor serum-free cell line sfRamos. Endocrinology 130:2446-2454, 1992
Baglia, L.A., D. Cruz, and J.E. Shaw. An Epstein-Barr virus-negative Burkitt lymphoma cell line secretes a prolactin-like protein during continuous growth in serum-free medium. Endocrinology 128:2266-2272, 1991
May, L.T., J.E. Shaw, A.K. Khanna, J.B. Zabriskie, and P.B. Sehgal. Marked cell-type differences in glycosylation of human interleukin-6. Cytokine 3:1-8, 1991
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