• Recruiting Clinical Trials
• Cornea Division
• Glaucoma Division
• Neuro Ophthalmology Division
• Retina Division
• Publications

Clinical faculty

• David Hirsh, M.D.
• Steven Katz, M.D.

• Deborah Grzybowski, Ph.D.

Now Recruiting!

IIH: Idiopathic Intracranial Hypertension Clinical Study Steven K. Katz, M.D. (PI), Deborah Grzybowski, Ph.D.

Idiopathic Intracranial Hypertension (IIH), also known as Pseudotumor cerebri, is a potentially blinding disorder affecting 1 in 20,000 people. The etiology is unknown; however, it is more common among obese women of childbearing age. Even though the incidence and morbidity of IIH are increasing, the treatments remain limited. The Department has partnered with the General Clinical Research Center at The OSU Medical Center to conduct a research study to identify factors (hormones/proteins) involved in IIH. Elucidating the mechanisms causing IIH will allow the development of more specific therapies for this disabling disease. The OSU Medical Center is looking for patients with suspected IIH who have NOT undergone diagnostic lumbar puncture (LP) and have NOT begun any treatment for the disease. The OSU Medical Center will coordinate and pay for the initial overnight hospital stay before the radiologically-guided LP. Patients enrolled in the study will provide samples of blood and excess cerebrospinal fluid obtained from the LP. Eligible patients will be seen on the day of contact or within several days depending on the degree of papilledema and risk of visual loss. If you have a patient that fits the following criteria, please call PRIOR to obtaining an LP or initiating treatment.

Contact Steven Katz, M.D. at 614-293-6892 or page 614-730-6223.

Current Clinical Trials

D Grzybowski (PI), SE Katz, C Johanson, E Harrison. An in vitro model of CSF outflow through the arachnoid membrane for IIH,  North American Neuro-Ophthalmology Society (NANOS) Pilot Research Grant, 2007–08.

D Grzybowski (PI), SE Katz, HN Nagaraja, M Failla, E Bourekas, EH Harrison. Clinical investigation of CSF and blood biological mediators of idiopathic intracranial hypertension – A pilot study, Health Services Strategic Initiative Research Grant, 2007–09.

Current Non-Clinical Studies

D Grzybowski (PI), SE Katz. Identification of vitamin A receptors in human arachnoid granulation tissue by western blot analysis and immunohistochemistry, OSU Strategic Initiative Grant (SIG), 2007.

Completed Clinical Trial & Non-Clinical Studies

 
Research Posters

• Human Arachnoid Granulation Probability of Occurrence and Surface Area Quantification
  DM Grzybowski, E.E. Herderick, K.G. Kapoor, D.W. Holman
• Mechanism of CSF Outflow Through Human Arachnoid Granulations
  DM Grzybowski, D.W. Holman, S. Glimcher, SE Katz, M. Lubow
• Human Arachnoid Granulation Topography and Surface Area Quantification
  DM Grzybowski, E.E. Herderick, K.G. Kapoor, D.W. Holman, SE Katz, M. Lubow
• Vitamin A Transduction Pathway in Static and Perfused Human Arachnoid Granulation Cell Cultures
  J.L. Hodges, DM Grzybowski, D.W. Holman, M. Lubow
• Hydraulic Conductivity of Human Arachnoid Granulation Cells (AGs) in an In Vitro Model of CSF Outflow
  D.W. Holman, DM Grzybowski, SE Katz, M. Lubow
• Ex Vivo Model of CSF Outflow through Human Arachnoid Granulations
  S. Glimcher, D.H. Holman, DM Grzybowski, SE Katz, M. Lubow
• An In Vitro Model of the Cerebrospinal Fluid Outflow Pathway Through the Arachnoid Granulations
  D.W. Holman, DM Grzybowski, SE Katz, M. Lubow
• Human Arachnoid Granulation Topography and Surface Area Quantification: Significance for PTC
  K.G. Kapoor, DM Grzybowski, E.E. Herderick, D.W. Holman, SE Katz, M. Lubow
• Vitamin A Transduction Pathways in Human Arachnoid Granulation Tissue and Culture
  J.L. Hodges, DM Grzybowski, D.W. Holman, SE Katz, M. Lubow
• Hydraulic Conductivity of Human Arachnoid Granulation Cap Cells in an In Vitro Model of Cerebrospinal Fluid Outflow
  D.W. Holman, DM Grzybowski, SE Katz, M. Lubow
• A Separation Technique to Isolate Arachnoid Cap Cells
  D.W. Holman, DM Grzybowski, B. Mehta, J.J. Chalmers
• Development of an In vitro Model to Study Pseudotumor Cerebri
  D.W. Holman, DM Grzybowski, K.G. Kapoor, B. Mehta, M. Lubow, SE Katz
• Development of a Separation Technique to Isolate Pia-Arachnoid Cells
  D.W. Holman, DM Grzybowski, B. Mehta, K.G. ., Kapoor, J.J. Chalmers, SE Katz, M. Lubow
• Development of Explantation Model for Human Pia-Arachnoid Cells
  K.G. Kapoor, DM Grzybowski, D.W. Holman, SE Katz, M. Lubow
• In Vitro Model of Cerebrospinal Fluid Outflow through Human Arachnoid Granulations
  DM Grzybowski, D.W. Holman, SE Katz, and M. Lubow

Research Papers

• DM Grzybowski, DW Holman, SE Katz, and M Lubow.  In Vitro Model of Cerebrospinal Fuid Outflow through Human Arachnoid Granulations
• DM Grzybowski, EE Herderick, KG Kapoor, DW Holman, and SE Katz. “Human arachnoid granulations Part I: A technique for quantifying area and distribution on the superior surface of the cerebral cortex.”  Cerebrospinal Fluid Research 2007, 4:6 (16 July 2007).
• DW Holman, DM Grzybowski, BC Mehta, SE Katz, and M Lubow Characterization of cytoskeletal and junctional proteins expressed by cells cultured from human arachnoid granulation tissue
• RM Rennebohm, M Lubow, J Rusin, L Martin, DM Grzybowski, JO Susac. “Aggressive immunosuppressive treatment of Susac's syndrome in an adolescent: using treatment of dermatomyositis as a model.”  Pediatr Rheumatol Online J. 2008 Jan 29; 6(1):3.
• M Lubow, DM Grzybowski, H Awad. “Denileukin Diftitox Vision Loss is Not PION.”  Leukemia and Lymphoma, Leuk Lymphoma. 2008 Feb; 49(2):370-1; author reply 372.
• B Mehta, DW Holman, DM Grzybowski, JJ Chalmers.  “Characterization of arachnoidal cells cultured on three-dimensional non-woven PET matrix.”  Tissue Eng. 2007 Mar 30; [Epub ahead of print] PMID: 17397271.