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 Gopi A. Tejwani, Ph.D.
Associate Professor
Vice Chair for Education
Chairman, Graduate Studies Program
Department of Pharmacology
5197 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210
Phone: (614) 292-7092
Email: tejwani.1@osu.edu
Curriculum Vitae
Research Interests Morphine tolerance and dependence
Endogenous opioid peptides such as beta-endorphin and met enkephalin are decreased, and Mu-opioid receptor is upregulated, in the discrete brain regions in the rat during addiction to morphine. A decrease in the CNS opioid peptides, and the formation of less potent Mu-opoiod receptor, lead to the development of morphine tolerance and dependence. Administration of a small dose of benzodiazepines decreases the development of morphine tolerance and dependence, and reverses the changes in opioid peptides and Mu-opioid receptor induced by morphine.
Electoacupuncture and opioid peptides Electoacupuncture significantly increases the skin pain threshold to thermal stimulus and increases the concentration of beta-endorphin in lumbar CSF, and minimally affectes behavior, respiratory and cardiovascular systems in adult mares.
Opioids, nicotine and smoking behavior Endogenous opioid peptides such as beta-endorphin and met-enkephalin are involved in pain modulation and reward systems, and may contribute to nicotine reinforcement. Animals subjected to main-stream tobacco smoke exhibit higher levels of plasma and CNS opioid peptides that are associated with naloxone reversible antinociception. Nicotine is responsible for smoking associated increase in antinociception and opioid peptides as nicotine administration also increases antinociception and CNS opioid peptides.
Naltrexone, an opioid receptor antagonist, when given to normal male and female human volunteers decreases the plasma nicotine levels, number of cigarettes smoked and self-reported satisfaction with smoking. The inhibition of ad libitum smoking in volunteers by naltrexone opens up the field for smoking cessation using various doses of naltrexone and nicotine replacement therapy.
My Other Pages Integrated Biomedical Graduate Program
Neuroscience Department
Publications
Isola R, Zhang H, Tejwani GA, Neff NH, Hadjiconstantinou M. (2008) Dynorphin and prodynorphin mRNa changes in the striatum during nicotine withdrawal. Synapse 62:448-455.
Isola R, Zhang H, Tejwani GA, Neff N, Hadjiconstantinou M. (2008) Psychopharmacology (in press).
Perspectives on teaching of pharmacology: Metamorphosis of teaching from blackboard to online electronic system. Tejwani GA. (2005) "Topics in the History of Pharmacology," P.M. Patil et al., editors, B.S. Shah Prakashan Publishers, Ahmedabad, India,pp. 210-244.
Developing an online course in General Pharmacology. Tejwani GA. (2004) Ohio Commons for Digital Education (OCDE) 2004 Conference. Online publication posted on http://www.oln.org/conferences/OCDE2004/papers/OCDE2004_Tejwani_Paper.pdf.
Role of spinal receptors in antinociceptive effects produced by intrathecal administration of hydromorphone and buprenorphine in the rat. Tejwani GA, Rattan AK. (2002) Anesthesia & Analgesia 94:1542-1546.
Met-enkephalin and preproenkephalin mRNA changes in the striatum of the nicotine abstinence mouse. Isola R, Zhang H, Duchemin A-M, Tejwani GA, Neff NH, Hadjiconstantinou M. (2002) Neurosci Letters 325:67-71.
Cutaneous analgesia, hemodynamic and respiratory effects, and B-endorphin concentration in spinal fluid and plasma of horses after acupuncture and electroacupuncture. Skarda RT, Tejwani GA, Muir WW III (2002) Amer J Vet Res 63:1435-1442.
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