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Richard Fertel, Ph.D. Associate Professor
Department of Pharmacology
5073 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210
Phone: (614) 292-1587
Email: fertel.1@osu.edu
Research InterestsBiochemical Pharmacology, Immunopharmacology, Control of cell function by pharmacologic alteration of cyclic nucleotide.
Research Area Macrophages produce nitric oxide in response to stimulation by a variety of factors. The stimulatory effects of interferon a and lipopolysaccharide on the macrophage can be distinguished by their differential response to adenosine. Our current work is focused on the role and mechanism of action of adenosine in the activation of macrophages.
Publications Biochemical and functional characterization of 1-benzyl substituted trimetoquinol affinity analogs on rat and human beta-adrenoceptors.. RC Mehta, MM Salazar-Bookaman, RH Fertel, AJ De Los, VI Nikukin, PF Fraundorfer et al. (2000) Biochem. Pharmacol. 59(5) : 517-529.
Beta-adrenoceptor subtype activities of trimetoquinol derivatives: Biochemical studies on human beta-adrenoceptors expressed in chinese hamster ovary cells.. AA Konkar, SS Vansal, G Shams, PF Fraundorfer, WP Zheng, VI Nikulin et al. (1999) J. Pharmacol. Exp. Ther. 291 : 875-883.
Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis.. Y Pei, LA Barber, RC Murphy, CA Johnson, SW Kelley, LC DY et al. (1998) J. Immunol 161(4) : 1954-1961.
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