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 Norton H. Neff, Ph.D.
Professor
Departments of Pharmacology and Psychiatry
Director of Medical Student Research
5067 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210
Phone: (614) 688-3887
Email: neff.2@osu.edu
Curriculum Vitae
Research InterestsNeurochemical pharmacology, Neurodegeneration; Neurotrophic Factors; Pharmacogenomics
Research Area:Research is focused on neurodegenerative disorders, primarily on Parkinson's diseases and aging. The mechanims for neurotrophic factor correction of degenerative processes is under study. In addition, preservation and stabilization of enzymes that are essential for neurotransmitter synthesis in degenerating neurons are an important part of the research activity. Animal models of neurodegenerative diseases, tissue culture systems, molecular biological techniques and isolated brain structures are utilized for study.
Program Affiliations
Neurosciene Graduate Program, Integrated Biomedical Science Graduate Program, OSU Program in Pharmacogenomics, CNS Pharmacogenomics Focus Group, Heart and Lung Research Institute.
PublicationsDuchemin AM, Ren Q, Neff NH, Hadjiconstantinou M. (2008) GM1-induced activation of phosphatidylinositol 3-kinase: Involvement of Trk receptors. J Neurochem 104:1466-1477.
Isola R, Zhang H, Tejwani GA, Neff NH, Hadjiconstantinou M. (2008) Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal synapse 62:448-455.
Hadjiconstantinou M, Neff NH. (2008) Enhancing aromatic l-amino acid decarboxylase activity: Implications for L-DOPA treatment in Parkinson disease. CNS Neurosci & Ther (in press).
Isola R, Zhang H, Tejwani G, Neff NH, Hadjiconstantinou M. (2008) Acute nicotine changes dynorphin and prodynorphin mRNA in striatum. Psychopharmacology (in press).
Neff NH, Wemlinger TA, Duchemin AM, Hadjiconstantinou M. (2006) Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. J Pharmacol Exp Ther 317:480-487.
Mo L, Ren Q, Duchemin AM, Neff NH, Hadjiconstantinou M. (2005) GM1 and ERK signaling in the aged brain. Brain Res 1054:125-134.
Copeland BJ, Neff NH, Hadjiconstantinou M. (2005) Enhanced dopamine uptake in the striatum following repeated restrain stress. Synapse 57:167-174.
Goettl VM, Zhang H, Burrows AC, Wemlinger TA, Neff NH, Hadjiconstantinou M. (2003) GM1 enhances dopaminergic markers in the brain of aged rats. Exp Neurol 183:665-672.
Goettl VM, Neff NH, Hadjiconstantinou M. (2003) Sciatic nerve axotomy in aged rats: Response of motoneurons and the effect of GM1 ganglioside treatment. Brain Res 968:44-53.
Duchemin AM, Ren Q, Mo L, Neff NH, Hadjiconstantinou M. (2002) GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain. J Neurochem 81:696-707.
Isola R, Zhang H, Duchemin AM, Tejwani GA, Neff NH, Hadjiconstantinou M. (2002) Met-enkephalin and pre-proenkephalin mRNA changes inthe striatum of the nicotine abstinence mouse. Neurosci Lett 325:67-71.
Goettl VM, Wemlinger TA, Colvin AE, Neff NH, Hadjiconstantinou M. (2001) Motoric behavior in aged rats treated with GM1. Brain Res 906:92-100.
Varol FG, Duchemin AM, Neff NH, Hadjiconstantinou M. (2000) Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy. Neurosci Lett 294:58-62.
Isola R, Duchemin AM, Tejwani GA, Neff NH, Hadjiconstantinou M. (2000) Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum. Brain Res 878:72-78.
Goettl VM, Wemlinger TA, Fong TG, Neff NH, Hadjiconstantinou M. (2000) Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside. Brain Res 877:1-6.
Neff NH, Wemlinger TA, Hadjiconstantinou M. (2000) SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons. J Neural Transm 107:429-443.
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