- The Jakeman Lab took a field trip to the Wexner Center on Thursday, November 6th to see Andy Warhol:  Other Voices, Other Rooms. This is a spectacular, US Exclusive, collection of the works of the artist that transformed art for the masses. The exhibit is Free to the public on Thursday evenings and tours are given at 5 PM Thursdays. It will run until Feb 15th at the Wexner, but is not scheduled for any other gallery. There is more there than you can see in many hours. We all thought that another visit with more time to browse would be worthwhile. Quite a bit of the subject matter is challenging to observe, as Warhol definitely had an unconventional view of normalcy.

November, 2008

Publications

- Mei Chi, Yingbi Zhou, Srikanth Vedamoorthyrao, Gopal J. Babu, Muthu Periasamy. Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice. PNAS, 2008, in press.

- Dmitry Terentyev, Inna Györke, Andriy E Belevych, Radmila Terentyeva, Arun Sridhar, Yoshinori Nishijima, Esperanza Carcache de Blanco, Savita Khanna, Chandan K Sen, Arturo J Cardounel, Cynthia A Carnes, Sandor Györke. Redox-Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca2+ leak in Chronic Heart Failure. Circulation Research, December, 2008.

Conferences/Presentations

- Dr. Woodattended the external scientific advisory board meeting for the University of North Carolina Center for Functional Gastrointestinal & Motility Disorders in the Division of Gastroenterology at Chapel Hill, NC on October 3, 2008.
- While at the University of North Carolina, Dr. Wood also presented a lecture  on “Enteric Degenerative Neuropathy” in the Division of Gastroenterology on October 4, 2008.

- Dr. Ziolo presented a seminar at Temple University in the Department of Physiology on October 16. The title was “NOS1 & NOS3: The Yin and Yang of Nitric Oxide Regulation of Cardiac Contractility”.

- Mark Kohr, a GRA in Dr. Ziolo’s lab, received 3^rd place at the Annual DHLRI Research Retreat Poster Competition on October 21. His poster was titled “Nitroxyl improves cardiac Myocyte contraction independent of L-type Ca²⁺ current”.

- Dr. Ziolo also presented a seminar titled “NOS1 & NOS3: The Yin and Yang of Nitric Oxide Regulation of Cardiac Contractility” at the University of Miami (FL) in the Department of Medicine, Division of Cardiology, on October 29.
- Dr. Periasamy will be a keynote speaker at the Ohio Physiological Society meeting on November 7, 2008 at 3:00pm. His presentation is entitled “Cardiac SR Ca²⁺ ATPase and Its Role in Heart Disease”. The OPS meeting is being held November 6 and 7 at the University of Toledo Health Science Campus.

Dr. Stephens traveled to Ataturk University in Erzurum, Turkey, in October, 2008, as a part of the formal exchange program existing with The Ohio State University.   ?  The ancient ruins of Ephesus, Turkey.
Dr. Stephens gave a workshop with Dr. Ahmet Hacimuftuglu regarding “In vivo voltammetric technology” at the 34th Physiology Congress on Oct 6th.
Dr. Stephens presented a plenary talk at the 34th Physiology Congress of the Turkish Physiological Society entitled “Use of in vivo voltammetry to study glutamatergic mechanisms on Oct 9th.
Dr. Stephens gave a lecture to 3rd year medical students titled “Multiple mechanisms mediating chronic pain” at Ataturk University on Oct 12th.
Dr. Stephens assisted in the opening of Dr. Ahmet Hacimuftuoglu’s laboratory with the rector of Ataturk University and the Dean of the Medical School at Ataturk University, Pharmacology Department in Erzurum, Turkey on Oct 15th.

Department News

Katie Quinter has joined Dr. Janssen’s lab as a Research Assistant. Katie grew up in Minster, Ohio, then attended Denison University where she was a collegiate volleyball player. She graduated in 2006 with degrees in Communication and Biology. While working in Dr. Janssen’s lab, she is in the process of applying to veterinary school. (FYI – Minster, in Auglaize County, is well known for its’ German heritage and they have a great Octoberfest! When in the area, always stop by the Wooden Shoe for great fried chicken!)

Lorry Kaple, a Research Associate in Dr. Boulant’s lab, won her second $50 gift card for completing the Annual Staff Satisfaction Survey. Congratulations, Lorry!!

October, 2008

Research Awards
- Billman GE. CV Therapeutic, "Effect of Ranolazine on Cardiac Autonomic Regulation", 09/01/08 - 08/31/09, $49,880.
- Billman GE. Sanofi-Aventis, "Effects of a Novel Compound on Susceptibility to Ventricular Fibrillation Induced by Myocardial Ischemia in a Conscious Canine Model of Sudden Cardiac Death", 10/01/08 - 9/30/09, $100,000.

Publications
- del Rio CL, Dawson TA, Clymer BD, Paterson DJ, Billman GE. Acute vagal nerve stimulation attenuates early passive electrical changes induced by myocardial ischaemia in dogs: heart rate-mediated attenuation.  Exp Physiol 93: 931-944, 2008.
- Billman GE. The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy.  Pharmacol & Therap 120: 54-70, 2008.
Abstracts
- Billman GE, Sridhar A, Nishijima Y, Terentyev D, Terentieva R, Uelmen R, Kukielka M, Robertson GA, Gyorke S, Carnes CA. "Repolarization abnormalities increase the susceptibility to ventricular fibrillation in a canine model of sudden cardiac death." Eur Heart J, 29 (abstract Suppl): 165, 2008.
- Billman GE, Kukielka M, del Rio CL, Goegelein H. Effect of the novel amiodarone-like compound SAR114646A on susceptibility to sudden death: prevention of ventricular fibrillation induced by myocardial ischemia. Eur Heart J, 29 (abstract Suppl): 633, 2008.

Conferences/Presentations
- Dr. Jack Rall attended the European Muscle Conference in Oxford, England from September 13 - 16 and made the following poster presentation:  “Effect of Ca binding properties of TnC on the rate of skeletal muscle tension redevelopment”, Ryan Lee, Svetlana Tikunova, Kristopher Kline, Darl Swartz*, Jack Rall, Jonathan Davis.
- Dr. Beth Lee, along with postdoctoral researcher Brooke McMichael and GRA Preeyal Kotadiya, traveled to Montreal, Quebec, for the 30th Annual Meeting of the American Society for Bone and Mineral Research (Sept. 12-16, 2008). Brooke presented a poster titled, "TRIP6 regulates osteoclast formation, adhesion, and resorptive capacity"; Preeyal presented a poster titled, "The role of alpha gene tropomyosins in osteoclast function"; and Dr. Lee co-chaired an oral session on osteoclasts.
- Dr. George Billman attended the European Society of Cardiology annual meeting in Munich, Germany, August 30 – September 3, 2008.
- On August 31, 2008, Dr. Billman presented "Repolarization abnormalities increase the susceptibility to ventricular fibrillation in a canine model of sudden cardiac death."

- On September 2, 2008, Dr. Billman presented "Effect of the novel amiodarone-like compound SAR114646A on susceptibility to sudden death: prevention of ventricular fibrillation induced by myocardial ischemia."
- The final presentation of Dr. Billman’s trip abroad was at the Cardiovascular Pharmacology Division, Sanofi-Aventis in Frankfurt, Germany on September 5, 2008. It was titled “Effect of Endurance Exercise Training on Cardiac Autonomic Neural Regulation and Susceptibility to Ventricular Fibrillation in a Canine Model of Sudden Cardiac Death.”
- Dr. Billman attended the American Physiological Society in Hilton Head, SC, September 24-27, 2008. On September 26, at the Integrative Biology of Exercise intersociety meeting, he presented "Effect of gender on the heart rate variability response to submaximal exercise in dogs with healed myocardial infarction."

Honors and Awards

The School of Biomedical Science recognized two of our Faculty who excel in their research and educational efforts. The SBS Executive Committee established the Excellence Awards in order to recognize, encourage and reward highly successful faculty who have contributed to the growth and mission of the SBS and Medical Center. Dr. George Billman and Dr. Jackie Wood were this year’s awardees from our Department. Congratulations!!

Department News

Dr. Ziolo announced that C.J. Traynham, a GRA in his lab, passed his candidacy exam on September 17. Congratulations, C.J.!!
Mamata Singh, a GRA in Dr. Lee’s lab, passed her candidacy exam on September 30. Congratulations Mamata!!

- The Department Faculty Retreat was held on Thursday, September 18, at the OSU Barrister Club. After a buffet lunch, Dr. Ziolo presented accomplishments made during 2007-2008 by the Graduate Research Associates in our Department. He also led discussion on enhancements to the Department’s GRA experience. Mary then presented a review of the Department’s finances. Dr. Jakeman led a discussion on the Merit Evaluation Committee, followed by Dr. Lucas with review of the Department’s Teaching Statistics and discussion for future planning. Following the break, Dr. Stephens presented information and led discussion on a Department Faculty Bonus/Incentive Plan. Dr. Billman then thanked everyone for coming and participating in the discussions.

- Congratulations to Dr. Robert Stephens on his 20 year anniversary at The Ohio State University.
- Welcome to Bill Speer, our PC Manager for Physiology and Cell Biology. Bill will be working 2 ½ days a week in our Department – all day on Mondays and Fridays, 1/2 day on Wednesdays. He will also be on call Tuesdays, Thursdays, and the other half of Wednesdays (when he is working in Ophthalmology) for PC emergencies. Bill will assist you with all your IT needs, including ordering new Dell PCs, diagnosing problem PCs, internet and LAN connections. You can contact Bill at speer.38@osu.edu or 247-7916. On his days in the Department, when not out and about, he is located in 412 Hamilton Hall.
- Also, welcome two new Graduate Research Associates to our Department. Seethalaks Hariharan has joined Dr. Strauch’s lab in the BRT and Matthew Sobo has joined Dr. Periasamy’s lab in Hamilton Hall. Welcome to our Department!!

“The Way I See It”
Isn't necessarily the way you see it
Or the way it is
Or ought to be
What's more important
is that we're all
looking for it
and a way to see it.
Desi Di Nardo

September, 2008

Publications
- Wright CL, Burgoon PW, Bishop GA, Boulant JA. 2008. Cyclic GMP alters the firing rate and thermosensitivity of hypothalamic neurons. American Journal of Physiology - Regulatory, Integrative & Comparative Physiology. 294: R1704-R1715  [PMID: 18321955]
- Unger NT, Kaple ML, Boulant JA. 2008. TRPV blockade by ruthenium red does not suppress thermosensitivity in hypothalamic neurons. FASEB Journal. 22: 956.15.

Conferences/Presentations
- Dr. Periasamy was an invited speaker at the 12^th International ATPase Conference: Na,K-ATPase and Related Transport ATPases of P-type: Structures, Mechanisms, and Roles in Health and Disease, in Aarhus, Denmark. The conference ran from August 5-10, 2008, and was organized by Jens Peter Andersen.

Department News
- Congratulations to the recipients of the latest round of Office of Postdoctoral Programs Travel Awards. Each will receive $650 to help pay travel expenses to present at the meeting indicated: (1) Brooke McMichael, postdoctoral researcher, Physiology and Cell Biology; 30th Annual Meeting of the American Society of Bone and Mineral Research; (2) Huating Wang, postdoctoral fellow, Comprehensive Cancer Center; The First EMBO Conference on the Molecular and Cellular Mechanisms Regulating Skeletal Muscle Development and Regeneration; and (3) Zhirong Yin, postdoctoral researcher, Comprehensive Cancer Center; 79th Annual Meeting of the American Thyroid Association. This award program was developed to help promote the career advancement of postdoc scholars in the College of Medicine and Office of Health Sciences.
-  Dr. Vandre has been selected as one of the 7 inaugural participants in the OSU Medical Center’s Faculty Teaching Scholars Program.  Congratulations, Dr. Vandre!!

"I've had smarter people around me all my life, but I haven't run into one yet that can outwork me. And if they can't outwork you, then smarts aren't going to do them much good. That's just the way it is. And if you believe that and live by it, you'd be surprised at how much fun you can have."
Woody Hayes


August, 2008

Publications
- McMichael BK, Lee BS. Tropomyosin 4 regulates adhesion structures and resorptive capacity in osteoclasts. Exp Cell Res. 2008; 314:564-73.
- Kotadiya P, McMichael BK, Lee BS. High molecular weight tropomyosins regulates osteoclast cytoskeletal morphology. Bone, DOI: 10.1016/j.bone.2008.06.017.
- Periasamy M, Kalyanasundaram A. SERCA2a gene therapy for heart failure: ready for primetime? Mol Ther. 2008 Jun;16(6):1002-4.

Conferences/Presentations
- On July 20-22, Dr. Lee traveled to the University of Toronto to act as an external reviewer for a dissertation defense. While there, she presented a seminar on "The Roles of Myosin Isoforms in Osteoclasts".
- Dr. Periasamy and his graduate student, Anu Kalyanasundaram, attended the Gordon Research Conference, July 20-24, in New London, NH. Dr. Periasamy presented a poster titled "Sarcolipin is a novel regulator of SERCA2a and atrial calcium transport", and Anu presented a poster "The point mutation CASQ2D307H does not affect Calsequestrin stability and targeting to the jSR".
- The Ziolo Lab also attended the Gordon Research Conference: Cardiac Regulatory Mechanisms. Honglan Wang, Mark Kohr, and CJ Traynham presented posters and competed for the Best Poster award.

Department News
- Congratulations to new Adjunct Faculty in the Department of Physiology and Cell Biology:

- Dr. Jhiang hired Lenguyen Huynh as a Research Associate in her lab.

The most important thing in the Olympic Games is not to win but to take part, just as the most important thing in life is not the triumph but the struggle. The essential thing is not to have conquered but to have fought well.

-Pierre de Coubertin, "The Olympic Creed" Inspired by Bishop Ethelbert Talbot, speech, Olympic Games 1908

July, 2008

Publications

- White RE, Yin QF, Jakeman LB. 2008. TGF-alpha increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice. Exp. Neurology (In press, June 2008).
- Jakeman LB, McTigue DM, Walters P, Stokes BT. 2008.  Contusive spinal cord injury, The OSU Model.  In:  Animal Models of Acute Neurological Injuries, The Humana Press Inc.  Contemporary Neuroscience Series (in press)
- White RE, Jakeman LB. 2008. Don't fence me in: Harnessing the beneficial roles of astrocytes after spinal cord injury.  Restorative Neurology and Neuroscience In Press, proofs returned 6/10/08.

- Mays TA, Binkley PF, Lesinski A, Doshi AA, Quaile MP, Margulies KB, Janssen PML, Rafael-Fortney JA. Claudin-5 levels are reduced in human end-stage cardiomyopathy. J Mol Cell Cardiol. 2008, in press. 

- Periasamy M, Janssen PML. Molecular basis of diastolic dysfunction. Heart Fail Clin. 2008, Jan;4(1):13-21. Review. 

- Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PML, Ziolo MT. Neuronal Nitric Oxide Synthase Signaling within Cardiac Myocytes Targets Phospholamban. Am J Physiol Cell Physiol. 2008, in press.

Conference/Presentations

- Dr. Ziolo and Honglan Wang, Mark Kohr, and CJ Traynham attended the International Society of Heart Research, American Section Conference, in Cincinnati, Ohio, June 17-20, 2008.

- Dr. Wood presented a lecture on: Neurogastroenterology: The Fundamentals at Procter & Gamble Pharmaceuticals in Mason, OH on Friday, June 6^th. 

- Dr. Wood, along with his colleague, Dr. Owen C. Peck, visited the Genentech Company in San Francisco on June 23rd for discussions with Genentech scientists on strategies for dealing with enteric neuropathies.

Department News

- Congratulations to Dr. Robinson reaching his 20 year anniversary with The Ohio State University!

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There are new faces in the labs of Dr. Jakeman: Ellen Andrews, Ph.D., started June 23 as a Postdoctoral Researcher. Luke Smith is an undergraduate research student for the summer from the OSU Department of Microbiology. Taylor Finseth (not shown) is a Class of 2010 Roessler Research Fellow for the summer from the COM. Stop by and welcome them to the Department!