Guo-Du Wang, M.D., Ph.D.
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Research Assistant Professor
303F Hamilton Hall
1645 Neil Avenue
Columbus OH 43210
wang.772@osu.edu |
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Education:
MD., Clinic Medicine, Medical College, China Three Gorges University, Yichang, P.R. China
M.S., Neurobiology, Tongji Medical University, Wuhan, P.R. China
Ph.D., Neuropharmacology, Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai, P.R. China
Postdoctoral researcher, Neuroscience, University of California Irvine, Irvine, CA, and Washington University, St Louis, MO.
Research Area:
Neurophysiology and Neuropharmacology
• Neurophysiology/Neurobiology of the Enteric Nervous System
• Gastrointestinal Motility
• Intestinal Secretion
• Enteric Neuroimmune Interactions
• Communication and functional modulation of CNS and ENS
Publications:
• Fang X, Liu S, Wang XY, Gao N, Hu HZ, Wang GD, Cook CH, Needleman BJ, Mikami DJ, Xia V, Fei GJ, Hicks GA, Wood JD. Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system. Neurogastroenterol Motil. 2007 Aug;20,80-93.
• Wang GD, Wang XY, Hu HZ, Liu S, Gao N, Fang X, Xia Y, Wood JD. Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1483-9. Epub 2007 Feb 22.
• Fang X, Hu HZ, Gao N, Liu S, Wang GD, Wang XY, Xia Y, Wood JD. (2006) Neurogenic secretion mediated by the purinergic P2Y(1) receptor in guinea-pig small intestine. Eur J Pharmacol.
• Liu S, Gao N, Hu HZ, Wang X, Wang GD, Fang X, Gao X, Xia Y, Wood JD. (2006) Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system. J Comp Neurol. 494(1):63-74.
• Wang GD , Wang XY, Hu HZ, Fang XC, Liu S, Gao N, Xia Y, Wood JD (2005). Angiotensin receptors and actions in guinea pig enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 289(3):G614-26.
• Liu S, Gao X, Gao N, Wang X, Fang X, Hu HZ, Wang GD, Xia Y, Wood JD. Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system. J Comp Neurol. 2005 Jan 17;481(3):284-98.
• Liauw J, Wang GD, Zhuo M (2003) NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice. Sheng Li Xue Bao. 55(4):373-80.
• Wang GD, Tao YX, Rumbaugh G, Zhao CS, Kauer F, Sutter R, O’Brien RJ, Zhuo M, Raja SN, Huganir RL, Bredt D, Johns RA (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Nuorosci. 23(17):6703-12.
• Liu S, Hu HZ, Gao C, Gao N, Wang GD, Wang X, Gao X, Xia Y, Wood JD(2003) Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine. Eur J Pharmacol.10;459(1):27-39.
• Liu S, Hu HZ, Gao N, Wang GD, Wang X, Peck OC, Kim G, Xia Y, Wood JD (2003) Neuroimmune Interactions in Guinea-Pig Stomach and Small Intestine: A Signaling Role for Histamine, Prostaglandins and Leukotrienes. Am J Physiol Gastrointest Liver Physiol.284 (1):G154-64.
• Wang GD, Zhuo M (2002) Synergistic enhancement of glutamate-mediated responses by serotonin and forskolin in adult mouse spinal dorsal horn neurons. J Neurophysiol. 87(2):732-9.
• Song P, Lie-Cheng W, Wang GD, Zhou Z, Zhao ZQ (2002) Interleukin-2 regulates membrane potentials and calcium channels via mu opioid receptors in rat dorsal root ganglion neurons. Neuropharmacology 43(8):1324-9.
• Wang GD, Robinson DA, Wei F, Li P, Kim SJ, Vogt SK, Muglia LJ, Zhuo M (2002) Oxytocin mediates stress-induced analgesia in adult mice. J Physiol. Apr 15;540(Pt 2):593-606.
• Kerchner GA, Wang GD, Qiu CS, Huettner JE, Zhuo M (2001) Direct presynaptic regulation of GABA/Glycine release by kainate receptors in the dorsal horn:an ionotropic mechanism. Neuron 32(3):477-488.
• Wang GD, Wei F, Kerchner GA, Kim SJ, Xu HM, Chen ZF, Zhuo M (2001) Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nature neuroscience 4(2): 164-169.
• Kerchner GA, Wei F, Wang GD, Kim AJ, Xu HM, Chen ZF, Zhuo M (2001) Do’smart’ mice feel more pain, or are they just better l earner? Nature-neurosciences 4(5):453-454.
Published Abstracts:
• Xia Y, Wang G-D, Wang X-Y, Liu S, Fei G, Wood JD. Sensitivity of guinea-pig small intestinal spinal afferents in models for food allergy and chemically induced inflammation. Neurogastroenterol. Mot. 2007, 19:38. The 21st ISNM, (poster presentation) in South Korea, Sep. 2-5,2007.
• Liu S, Qu M-H, Hu H-Z, Gao N, Wang G-D, Wang X-Y, Fei G, Zou F, Xia Y, Wood JD. Differential expression of TRPC channels in the guinea-pig enteric nervous system. Neurogastroenterol. Mot. 2007, 19:40. The 21st ISNM, (poster presentation) in South Korea, Sep. 2-5,2007.
• Wang G-D, Wang X-Y, Liu S, Fei G, Xia, Y, Wood JD. Receptors for dopamine in the enteric nervous system of guinea pig small intestine. Neurogastroenterol. Mot. 2007, 19:41. The 21st ISNM, (poster presentation) in South Korea, Sep. 2-5,2007.
• Fei G, Du Y, Wang X-Y, Zou F, Liu S, Qu M-H, Xia Y, Wang G-D, Wood JD. Stimulation and inhibition of mucosal secretion by dopamine D1 and D2 receptors in the enteric nervous system (ENS) of guinea pig small intestine. Neurogastroenterol. Mot. 2007, 19:41. The 21st ISNM, (poster presentation) in South Korea, Sep. 2-5,2007.
• Fei G, Liu S, Qu M-H, Wang G-D, Wang X-Y, Zou F, Xia Y, Bohn L, Wood JD. Lubiprostone by passes morphine-induced inhibition of secretion in guinea pig intestine. Neurogastroenterol. Mot. 2007, 19:60. The 21st ISNM, (poster presentation) in South Korea, Sep. 2-5,2007.
• Guo-Du Wang, Xi-Yu Wang, Guijun Fei, Sumei Liu, Fei Zou, Youqin Du, Mei-Hua Qu, Yun Xia, Jackie D Wood. Synaptic Behavior in the Enteric Nervous System (ENS) of Guinea-pigs with Experimentally-induced Enterocolitis or Food Allergy. Gastroenterology, 132(4, Suppl 2):A-332. DDW meeting (poster presentation) May 2007 in Washington DC.
• Xi-Yu Wang, Guo-Du Wang, Yun Xia, Sumei Liu, Guijun Fei, Fei Zou, Youqin Du, Mei-Hua Qu, Jackie D Wood. Enteric Mast Cells in Experimental Allergic and Non-Allergic Enterocolitis in Guinea-pigs. Gastroenterology, 132(4, Suppl 2):A-332. DDW meeting (poster presentation) May 2007 in Washington DC.
• Guijun Fei, Sumei Liu, Guo-Du Wang, Mei-Hua Qu, Xi-Yu Wang, Fei Zou, Youqin Du, Yun Xia, Laura M Bohn, Jackie D Wood. Stimulation of Mucosal Secretion by Lubiprostone in Guinea-pig Small intestine and Colon. Gastroenterology, 132(4, Suppl 2):A-683. DDW meeting (poster presentation) May 2007 in Washington DC.
• Mei-Hua Qu, Xi-Yu Wang, Sumei Liu, Guo-Du Wang, Guijun Fei, Fei Zou, Youqin Du, Yun Xia, Jackie D Wood. Brandykinin-Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Rlease in the Enteric Nervous System of Guinea-pig Small Intestine. Gastroenterology, 132(4,Suppl 2):A-330. DDW meeting (poster presentation) May 2007 in Washington DC.
• Mei-Hua Qu, Hong-Zhen Hu, Na Gao, Guo-Du Wang, Xi-Yu Wang, Guijun Fei, Fei Zou, Youqin Du, Yun Xia, Jackie D Wood, Sumei Liu. Synaptic Activation of Trpc Channels By Metabotropic Purinergic P2Y1 Receptors in the submucosal Plexus of the Guinea-pig Small Intestine. Gastroenterology, 132(4,Suppl 2):A-18. DDW meeting (Oral presentation) May 2007 in Washington DC.
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