306/309 Hamilton Hall
1645 Neil Avenue
Columbus, Ohio 43210-1218
PhD, Physiology, Lomonosov Moscow State University, Moscow, Russia
MS, Biophysics and Biomedical Engineering, Moscow Institute of Physics and Technology, Moscow, Russia
Our research is focused on the fundamental mechanisms of cardiac pacemaker activity and arrhythmogenesis in the heart, using state-of-the-art optical mapping techniques.
Our main research interest is to understand how sino-atrial node (SAN) pacemakers dysfunction and atrial fibrillation (AF) can occur due to congestive heart failure, aging, and tachycardia remodelling.
AF is the most prevalent cardiac arrhythmia, affecting over 2.2 million Americans, leading to hospitalization and morbidity. While significant progress has been made in elucidating the basic mechanisms of AF and flutter (AFL), the role of the SAN in inducing and maintaining these clinically-prevalent arrhythmias has yet to be explored. We have previously identified discrete sino-atrial conduction pathways (SACPs) that mediate conduction between the SAN pacemaker complex and the surrounding atrial myocardium.
Using 3D high-resolution optical mapping, we unmasked revealed unique interactions describing the dependency between the SAN pacemaker complex, conduction pathways, and surrounding atrial myocardium during normal rhythm and AF/AFL.
One of the goals of our laboratory is to define the role of the sinoatrial conduction pathways in the mechanisms of AF and SAN dysfunction during heart failure and myocardial infarction. Our research will unmask hidden secrets of cardiac dysfuntions and arrhythmias and lead to the development of both novel pharmacological and/or genetic/cellular therapeutic strategies.
- Fedorov VV, Schuessler RB, Hemphill M, Ambrosi CM, Brown K, Chang R, Hucker WJ, Efimov IR. Structural and functional evidence for discrete exit pathways that connect the canine sino-atrial node and atria. Circulation Research, 2009: 104:915-923
- Glukhov AV, Fedorov VV, Lou Q, Schuessler RB, Moazami N, Efimov IR. Transmural dispersion of repolarization in normal and failing human ventricle. Circulation Research, 2010: 19;106(5):981-91 (with editorial).
- Efimov IR, Fedorov VV, Joung B, Lin SF. Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping. Circulation Research, 2010;106(2):255-71.
- Glukhov AV, Fedorov VV, Mohler PJ, Anderson ME, Efimov IR. Functional anatomy of the murine sinus node: Evidence from high-resolution optical mapping. Am J Physiol. 2010: 299(2):H482-91.
- Fedorov VV, Glukhov AV, Chang R, Kostecki G, Aferol HA, Hucker WJ, Moazami N, Schuessler RB, Efimov IR. Optical mapping of the isolated coronary-perfused human sinus node. JACC. 2010;56:1386–94 (with editorial).
- Fedorov VV, Chang R, Glukhov AV, Kostecki G, Janks D, Schuessler RB, Efimov IR. Complex interactions between the sinoatrial node and atrium during reentrant arrhythmias in the canine heart. Circulation, 2010;122:782-789.
- Ambrosi CM, Ripplinger CM, Efimov IR, Fedorov VV. Termination of sustained atrial flutter and fibrillation using low energy multiple shock therapy. Heart Rhythm, 2011 8(1):101-8 (with editorial and cover page).
- Fedorov VV, Glukhov AV, Ambrosi CM, Kostecki G, Chang R, Janks D, Schuessler RB, Moazami N, Nichols CG, Efimov IR. Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. JMCC. 2011:51(2):215-225.
- Lou Q, Fedorov VV, Glukhov AV, Moazami N, Fast VG, Efimov IR. Transmural Heterogeneity and remodeling of rentricular excitation-contraction coupling in human heart failure. Circulation. 2011; 123:1881-1890.
- Fedorov VV, Ambrosi CM, Kostecki G, Hucker WJ, Glukhov AV, Wuskell J, Loew LM, Moazami N, Efimov IR. Anatomic localization and autonomic modulation of AV junctional rhythm in failing human hearts. Circulation – Arrhythmia and Electrophysiology. 2011; 4(4):515-525.
- Li W, Janardhan AH, Fedorov VV, Sha Q, Schuessler RB, Efimov IR. Low Energy Multi-Stage Atrial Defibrillation Therapy Terminates Atrial Fibrillation with Less Energy than a Single Shock. Circulation – Arrhythmia and Electrophysiology. 2011; 4(6):917-25.
- Lou Q, Fedorov VV. Shock-Induced Focal Arrhythmias: Not Driven by Calcium? Heart Rhythm. 2012;9(1):105-106.
- Glukhov AV, Fedorov VV, Kalish PW, Ravikumar VK, Lou Q, Schuessler RB, Moazami N, Efimov IR. Conduction remodeling in human end-stage non-ischemic left ventricular cardiomyopathy. Circulation, 2012; 125(15):1835-4.
- Fedorov VV, Glukhov AV, Chang R. Conduction barriers and pathways of the sino-atrial pacemaker complex: their role in normal rhythm and atrial arrhythmias. Am J Physiol, 2012; 302(9):H1773-83
- Ambrosi CM, Fedorov VV, Schuessler RB, Rollins AM, Efimov IR. Quantification of Fiber Orientation in the Canine Atrial Pacemaker Complex using Optical Coherence Tomography. Journal of Biomedical Optics. 2012; 17(7):071309.
- Lou Q, Glukhov AV, Hansen B, Hage L, Vargas-Pinto P, Billman GE, Carnes CA, Fedorov VV. Tachy-Brady Syndrome: the critical role of adenosine-induced sino-atrial conduction block in post-tachycardia pauses. Heart Rhythm, 2013;10(1):110-118 (with editorial)
- Glukhov AV, Hage L, Hansen BJ, Pedraza-Toscano A, Vargas-Pinto P, Hamlin RL, Weiss R, Carnes CA, Billman GE, Fedorov VV. Sinoatrial node micro-reentry in a canine chronic left ventricular infarct model: the role of intranodal fibrosis and heterogeneity of refractoriness. Circulation Arrhythmia & Electrophysiology, in press, published online August 19, 2013.
- Glukhov AV, Kalyanasundaram A, Lou Q, Hage L, Hansen BJ, Belevych A, Mohler PJ, Knollmann BC, Periasamy M Gyorke S, Fedorov VV. Calsequestrin2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex. European Heart Journal, 2013 in Press (Impact factor 14.723)
- Lou Q, Hansen BJ, Fedorenko O, Csepe T, Hage L, Li N, Kalyanasundaram A, Glukhov AV, Billman G, Weiss R, Mohler PJ, Gyorke S, Biesiadecki BJ, Cynthia CA, Fedorov VV. Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping. Circulation, 2014;130: 315-324 (Impact factor 15.202)
PDF: http://circ.ahajournals.org/content/early/2014/05/16/CIRCULATIONAHA.113.007086.full.pdf? ijkey=UEobzxsNUPWWIfn&keytype=ref
- Kalyanasundaram A and Fedorov VV. Fibroblast Growth Factor 23: A Novel Key to Find Hidden Substrates of Atrial Fibrillation? Circulation, 2014; 130: 295-297 (Impact factor 15.202)