Ohio State Navbar

Sign In

Sanjay Rajagopalan, MD

Sanjay Rajagopalan, MD
John W. Wolfe Professor of Cardiovascular Medicine
Associate Director, DHLRI Vascular Research
Phone: (614) 247-7760
Email: Sanjay.rajagopalan@osumc.edu











Our laboratory is interested in multifunctional targeted agents for imaging and therapy in inflammation and atherosclerosis. We believe that targeted theranostic (diagnostic and therapeutic) agents that enable non-invasive assessment of high risk features and simultaneously allow therapy for treatment of inflammation may have potential applications in inflammatory disorders such as atherosclerosis and diabetes.  Our laboratory is interested in multimodal approaches and in particular MRI imaging of plaque inflammation. We have successfully employed nanovesicles coupled with with a variety of signals recognized by innnate immune cells allowing detection via MRI. Recently we have focused on select highly expressed ligands in inflammation and are now successfully targeting these by means of multifunctional theranostics. The approaches being developed in our laboratory have broad applicability in humans and provide new strategies that are clinically translatable.
Team Members
Aixia Wang – Lab Technician
Andrei Maiseyeu – Postdoc, Lab Manager
Arthur Wang – Graduate Student
Brian Mog - Undergraduate
Cuiqing Liu - Postdoc
Dheeraj Duggineni – Undergraduate
Jeff Deiuliis - Postdoc
Jixin Zhong - Postdoc
Liubov Gushchina - Postdoc
Marcus Badgeley – Graduate Student
Qinghua Sun – Associate Professor of Cardiovascular Medicine
Sanjay Rajagopalan – John W. Wolfe Professor of Cardiovascular Medicine
Xiaohua Xu - Postdoc
Xiaoquan Rao - Postdoc
Yuntao Bai – Doctorate Student
Zach Braunstein - Undergraduate
Zhekang Ying – Postdoc
Names of Members in the Group with Position Title
Aixia Wang – Lab Technician
Andrei Maiseyeu – Lab Manager
Arthur Wang - Postdoc
Brian Mog - Undergraduate
Cuiqing Liu - Postdoc
Dheeraj Duggineni – Undergraduate
Jeff Deiuliis - Postdoc
Jixin Zhong - Postdoc
Liubov Gushchina - Postdoc
Marcus Badgeley – Undergraduate
Qinghua Sun – Associate Professor of Cardiovascular Medicine
Sanjay Rajagopalan – John W. Wolfe Professor of Cardiovascular Medicine
Xiaohua Xu - Postdoc
Xiaoquan Rao - Postdoc
Yuntao Bai – Doctorate Student
Zach Braunstein - Undergraduate
Zhekang Ying – Postdoc
Research Interests
Dr. Rajagopalan’s research interests for over a decade center around how risk factors modulate inflammation in the cardiovascular system. This work has contributed to our understanding of how risk factors may modulate vascular inflammation and susceptibility to atherosclerosis.
Selected Publications
Maiseyeu A, Rajagopalan S.  Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis. J. Lipid. Research 2009: 50: 2157

Sanz J, Fuster V, Rajagopalan S. Evaluation of Pulmonary Artery Stiffness in Pulmonary Hypertension with Cardiac Magnetic Resonance. Journal of the American College of Cardiology: Cardiovascular Imaging 2009; 2(3):286-295

Maiseyeu A, Rajagopalan S. Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: an approach for atherosclerosis imaging. Nanomedicine 2010; 5: 1341.

Mihai G, Simonetti OP, Rajagopalan S. Initial Feasibility of a Multi-Station High Resolution Three-Dimensional Dark Blood Angiography Protocol for the Assessment of Peripheral Arterial Disease. Journal of Magnetic Resonance Imaging 2009; 30(4):785-793.

Mihai G, Simonetti OP, Rajagopalan S. T1-Weighted-SPACE Dark Blood Whole Body Magnetic Resonance Angiography (DB-WBMRA): Initial Experience. Journal of Magnetic Resonance Imaging 2010; 31(2):502-509. 

Shah Z, Kamprath T, Maiseyeu A, Rajagopalan S.  Circulation. Long-Term Depeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis Circulation. 2011;22;124(21):2285-9.

Maiseyeu A, Rajagopalan S. In Vivo Targeting of Inflammation Associated Myeloid-Related Protein 8/14 via Gadolinium Immunonanoparticles. Arterioscler Thromb Vasc Biol. 2012: in press.