Nicanor I. Moldovan, PhD
Research Associate Professor
Department of Internal Medicine
Division of Cardiovascular Medicine
Investigator, Davis Heart and Lung Research Institute
Phone number: (614) 247-7801
Dr. Moldovan’s lab is developing the following projects in the field of Regenerative Medicine, in collaboration with biologists, engineers and physicians: A) Identification and characterization of circulating progenitor cells using Systems Biology principles (“Repairome”) and cytomics (single-cell level) methods, for diagnostic and prognostic purposes. B) Tissue engineering of peri-implant space using stem/progenitor cells and fibrous synthetic scaffolds, for the control of foreign body reaction; C) Modeling of cellular robustness using experimental methods and computational stochastic mechanics, for cell therapy applications.
Detection of stem/progenitor cells, neovascularization, tissue engineering, cell therapy, endothelial biology, cellular biomechanics, computer modeling
Jain H., Moldovan N. I., Byrne, H. Modeling stem/progenitor cell-induced neovascularization and oxygenation around solid implants, Tissue Engineering (Part C), (2012, in press)
Guan J, Wang F, Li Z, Chen J, Guo X, Liao J, Moldovan NI. Stimulation of cardiac differentiation of mesenchymal stem cells in tissue constructs that mimic myocardial structure and biomechanics. Biomaterials. 2011, 32:5568-80.
Lenormand G, Millet E, Park CY, Hardin CC, Butler JP, Moldovan NI, Fredberg JJ. Dynamics of the cytoskeleton: how much does water matter? Phys Rev E Stat Nonlin Soft Matter Phys. 2011, 83:061918.
Moldovan NI. Regenerative medicine: the promises and perils of a Promethean task. J Cell Mol Med. 2010, 14:2189.
Sengupta N, Caballero S, Sullivan SM, Chang LJ, Afzal A, Li Calzi S, Kielczewski JL, Prabarakan S, Ellis EA, Moldovan L, Moldovan NI, Boulton ME, Grant MB, Scott EW, Harris JR. Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Mol Ther. 2009, 17:1594-604.
Butt OI, Carruth R, Kutala VK, Kuppusamy P, Moldovan NI. Stimulation of peri-implant vascularization with bone marrow-derived progenitor cells: monitoring by in vivo EPR oximetry. Tissue Eng. 2007, 13:2053-61.
Anghelina M, Moldovan L, Zabuawala T, Ostrowski MC, Moldovan NI. A subpopulation of peritoneal macrophages form capillary-like lumens and branching patterns in vitro. J Cell Mol Med. 2006, 10:708-15.
Anghelina M, Krishnan P, Moldovan L, Moldovan NI. Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am J Pathol. 2006, 168:529-41.
Moldovan NI. Functional adaptation: the key to plasticity of cardiovascular "stem" cells. Stem Cells Dev. 2005, 14:111-21.
Anghelina M, Krishnan P, Moldovan L, Moldovan NI. Monocytes and macrophages form branched cell columns in Matrigel: implications for a role in neovascularization.Stem Cells Dev. 2004, 13:665-76.