Zhongming Zhao, PhD, will present a lecture entitled "Pathway- and Network-based Analysis of Genome-wide Association Studies and RNA Sequencing Data" August 30, 2011 at 1:00pm in 3167 Graves Hall.
Genome-wide association studies (GWAS) have become a popular approach to search for common genetic variants with susceptibility to complex diseases or traits. Recently, pathway- or network-based analysis of GWAS datasets has emerged as an alternative but potentially powerful search approach for disease causal genes, assuming a complex disease may have resulted from a number of genes that disrupt one or more pathways or protein complexes. This talk covers several methods and approaches that have been applied to GWAS datasets, including hypergeometric test, Gene Set Enrichment Analysis (GSEA), dense module search for GWAS in protein-protein interaction network (dmGWAS), their applications in a few complex diseases, and a comparative analysis of GWAS and RNA sequencing (RNA-Seq) data in schizophrenia. Some integrative genomics projects will also be briefly presented.
The Department of Biomedical Informatics and the Division of Hematology are hosting this event.