Theresa M. Koehler, PhD, Herbert L. and Margaret W. DuPont Professor, Chair ad interim, Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, will present Virulence Gene Expression by the Anthrax Bacterium: A Unique Regulator's in Host-Pathogen Signaling as part of the Host-Pathogen Seminar Series in the Center for Microbial Interface Biology.
Virulence of Bacillus anthracis, the causative agent of anthrax, is associated with synthesis of the anthrax toxin proteins, protective antigen, lethal factor, and edema factor, and an anti-phagocytic capsule composed of poly-D-glutamic acid. Dr. Koehler's lab focuses on the genetic basis for expression of the structural genes for the toxin proteins, the capsule biosynthesis operon, and other genes with a known or suspected role in virulence. The model for virulence gene regulation in B. anthracis is of growing complexity and includes numerous trans-acting regulators. The most critical and far-reaching of these is AtxA, a transcriptional regulator with unique properties. Dr. Koehler's talk will focus on molecular mechanisms for controlled expression and function of this important protein.
Co-sponsored by the Department of Microbiology.
Date: Monday, November 21, 2011
Place: 115 Biomedical Research Tower
Contact for questions: Laura Brady