Text on screen: The Ohio State University Wexner Medical Center] Speaker 1: Welcome to the Gumina Lab at The Ohio State University Wexner Medical Center. [Screen shows a hand writing out "WELCOME TO THE GUMINA LAB] In the United States, heart disease is the number one killer. [Screen shows a hand writing "In the United States" and then drawing the outline of the United States with an anatomical heart drawn inside the outline] Atherosclerotic cardiovascular disease, the leading cause of heart disease, is an inflammatory process. [Screen shows a hand writing "Atherosclerosis is Driven by Inflammation" and then drawing out the inflammation cycle] Initial vessel wall injury leads to local inflammation and immune cell infiltration. [The screen shows a hand drawing an anatomical heart and then zooms in on a single vessel to showcase initial lesion (normal histology machrophage infiltration), fatty streak (intracellular lipid accumulation), and an intermediate lesion(extracellular lipid core development)] This results in progression of disease that can lead to severe vessel narrowing. [The hand continues to draw more vessel images including atheroma (intracellular and extracellular lipid accumulation), fibrous plaque (fibrotic/calcific layers), and complicated lesion/rupture(plaque rupture, thrombosis, and blockage of blood flow)] A myocardial infarction, or heart attack, is caused by the sudden lack of blood flow to a portion of the heart that can lead to heart muscle death if not treated promptly. [Screen shows a red arrow pointed to an anatomical heart labeled "Myocardial Infarction (Heart Attack") and this heart's ventricles have a dark spot drawn on them that is being circled by a black arrow] The blockage in blood flow is caused by the rupture of an unstable atherosclerotic plaque that results in thrombus formation. [Screen shows a hand drawing a blood vessel with significant plaque build-up that results in another build up which is labeled as a "Thrombus"] When a patient has a heart attack, this is a medical emergency and time is of the essence. [Screen shows a drawing of the Ross Heart Hospital and an ambulance with the title: "WHEN A PATIENT HAS A HEART ATTACK, TIME IS OF THE ESSENCE."] Once at the hospital, a team led by an interventional cardiologist must perform an emergent heart catheterization to identify the blockage in the artery and place a stent, a metal device that opens the artery and restores blood flow. [Screen shows a big red arrow drawn from the previous hospital drawing to an image of an operating room and a blocked artery. A hand then draws out the image sequence of placing a stent including stent delivery, balloon inflation, and stent in place] The goal is to save heart muscle and to return our patients to a healthy and productive life. [Screen shows a hand drawing a park scene with trees and a trail that three adults are seen running on] Doctor Gumina is a physician-scientist and interventional cardiologist who leads a funded research program. [Screen shows a picture of Dr. Gumina and two pictures of The OSU Wexner Medical Center as a hand writes "Dr Gumina is a physician-scientist (MD, PhD) and interventional cardiologist. He leads a NHLBI and AHA funded research program] His team of talented investigators is unraveling the factors that contribute to cardiovascular disease. [Screen shows 6 faces labeled Emilee, Shamama, Kyle, Sam, Oscar, and Roman while the hand writes, "His team of talented investigators is unraveling the factors that contribute to cardiovascular disease] By obtaining blood from our patients, the door to understanding the causes of heart disease is unlocked. [Screen shows an image of a medical professional taking blood from a patient] Processed blood yields not only individual cells, but also protein, RNA, and DNA for study. [Screen shows an arrow from the previous slide drawn to a centrifuge machine with a close up of a centrifuge tube; this tube then has an arrow drawn from it to another tube with a close up of individual cells, protein, RNA, DNA, and then DNA sequencing] Our DNA code is what makes us all individuals. [Screen shows a DNA sequencing graph and a group of people] These differences in our DNA code can impact the level and activity of proteins and how cells respond. [Screen shows a hand drawing three different people with different nucleotide base pairs; an arrow is then drawn to an image of the immune system response] Doctor Gumina and his lab have focused on specific molecules on immune cells. [Screen shows a hand drawing an immune cell with a cross section of CD39 and CD73 being zoomed in on] CD39 and CD73 act in concert to break down pro-inflammatory and pro-thrombotic ATP and ADP to anti-inflammatory and antithrombotic adenosine. [Screen shows CD39 and CD73 in the membrane of the immune cell with ATP and ADP drawn under the title "PRO-inflammation thrombotic" and AMP and Adenosine drawn under "ANTI-inflammation thrombotic"] We are studying how genetic differences in CD39 and CD73 impact atherosclerosis, thrombosis, inflammation and cardiac healing. [Screen shows an image of thrombosis, an image of atherosclerosis, an image of inflammation, and an image of heart healing] From bench to bedside and bedside to bench, the Gumina Lab is unraveling the factors that affect coronary artery disease and how the heart heals after a heart attack. [Screen shows a medical professional taking care of a patient in a hospital bed with an arrow drawn forwards and backwards to images of DNA, a petri dish, and a molecular compound] To learn how you can be part of this exciting work, please contact Doctor Gumina. [Screen shows a hand writing, "contact Dr Gumina at richard.gumina@osumc.edu].