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Biomedical Informatics Calendar

January 2019
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BMI Seminar Series : Ying Yuan : "BOIN: A Novel Platform for Designing Phase I Clinical Trials"
Start: 1/18/2019 11:00:00 AM
End: 1/18/2019 12:00:00 PM
Location: 105 BRT

Abstract: Bayesian optimal interval (BOIN) designs belong to a new class of early phase trial designs known as model-assisted designs, which utilize statistical models for efficient decision making, but their dose transition rules can be pre-tabulated as the 3+3 design. The BOIN design can be implemented in a simple way as the 3+3 design, but yields superior performance comparable to model-based designs. In this talk, we will introduce a suite of BOIN designs that can be used to find the maximum tolerated dose (MTD) for single-agent trials, drug-combination trials, as well as trials with late-onset toxicity, under a unified framework. The freely available software at www.trialdesign.org will be demonstrated using trial examples.

posted by: Biomedical Informatics