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Vadim Fedorov, PhD

Department of Physiology and Cell Biology

Email: fedorov.2@osu.edu and vadimfed@gmail.com

Web page: http://medicine.osu.edu/physiology/faculty-research/vadimfedorov/pages/index.aspx​

 

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Research Description

In my lab we pursue two main directions: 1) determining the mechanism of function and dysfunction of the main cardiac pacemaker, the Sino-Atrial Node (SAN) and 2) finding novel treatment strategies for prevalent cardiac arrhythmias, such as atrial fibrillation (AF). In my lab at The OSU, I developed a high resolution imaging system, which is capable of resolving intramural activation of the complex 3D atrial structure in human hearts (Hansen et al., European Heart Journal 2015, Li at al Circulation 2016, Li et al., Science Translational Medicine 2017).  Our group utilizes integrated state-of-the-art 3D imaging approaches to uncover the functional, structural, and molecular mechanisms of malignant cardiac arrhythmias directly in the human heart.

 

1)         Sinoatrial Node Structure and Function. Much of my efforts have been focused on studying the function and structure of the human sinoatrial node, the primary pacemaker of the heart. We have contributed critical knowledge in this field by showing that in adult canine and human hearts, fatty tissue and fibrosis insulate the SAN from the hyperpolarizing effect of the surrounding atria while electrical communication between the SAN and right atrium is restricted to discrete SAN conduction pathways. We have also showed that pathological upregulation of fibrosis within the human SAN may lead to tachycardia-bradycardia arrhythmias and cardiac arrest, possibly due to SAN reentry and intranodal conduction blocks (Li et al., Science Translational Medicine 2017).

2)         Atrial Fibrillation Mechanisms and Treatments.  In my lab at the OSU, we developed an integrated approach for defining the exact sources of AF and their electrical, structural and molecular mechanisms with the future goal of highly selective and safe diagnoses and treatments for AF patients. By using this approach we demonstrated for the first time that AF is driven by intramural reentry anchored to specific microanatomic tracks in diseased human atria (Hansen et al., European Heart Journal 2015, Li et al., Circulation 2016, and Hansen et al., JACC CEP 2017). Patient specific targeted modulation of this structural substrate will allow for significant improvements in AF treatment.

 

This is a unique opportunity to work on groundbreaking projects in a laboratory with state-of-the-art equipment, including panoramic and transmural optical mapping and contrast-enhanced magnetic resonance imaging. The successful applicant will join a lively multi-disciplinary team including physiologists and cell biologists, biomedical engineers, clinical electrophysiologists, and cardiac surgeons in an outstanding research environment at the Ohio State University Wexner Medical Center.

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