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F. Kay Huebner, PhD

Professor

Department of Molecular Virology, Immunology and Medical Genetics Human Cancer Genetics Program

Contact Information


Office:

916 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Ph: (614) 292-4850
laboratory phone: 614-292-3716
fax 614-292-3312
email address: kay.huebner@osumc.edu 

Research Interest

Cancer, DNA Damage, Carcinoma, Breast Cancer, Carcinoma, Renal Cell, Loss of Heterozygosity, Leukemia, Lung Cancer

 The major focus of the laboratory is to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human cancers. The biological functions of the two proteins are studied using the full panoply of molecular genetic techniques in in vitro and in vivo models. Tumor suppressor related changes defined in tissue culture or mouse models are quickly examined also in human tissues from anonymous human cancers in order to confirm the laboratory findings in actual human cancers of breast, pancreas and other cancers, with the ultimate goal of identifying  prognostically useful protein markers and possible therapeutic targets for specific cancers.


Education and Training

PhD, Microbiology, University of Pennsylvania, 1974
Postdoctoral Training, Molecular Genetics, The Wistar Institute Cancer Center, Philadelphia, PA


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