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Marshall V. Williams, PhD

Professor

 

Joint Appointment

Department of Microbiology

Contact Information


Office:

353 Institute for Behavioral Medicine Research
460 Medical Center Drive
Columbus, Oh. 43210
Ph. (614) 293-6175
E-Mail: marshall.williams@osumc.edu

Laboratory:

2167L Graves Hall
333 W. 10th Avenue
Columbus, Oh. 43210
Ph. (614) 292-0986

Research Interest

Pyrimidine deoxyribonucleotide metabolism in human and herpesviruses infected cells. Mechanism(s) of mutagenesis by environmental pollutants. 

Research Summary

Project 1: DNA Replication and Repair: Elucidating the role(s) of deoxyuridine triphosphate nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UNG) in normal cellular (human) metabolism and virus replication. For the past 20 years research in my laboratory has focused on determining the role(s) of these deoxyuridine triphosphate nucleotidohydrolase (dUTPase) and uracil-DNA glycosylase (UNG) in normal cellular metabolism and in virus replication (herpes simplex virus type 2, Epstein-Barr virus and human immunodeficiency type-1). The goal of this research is to use these enzymes as targets for the development of novel agents for use in cancer and viral chemotherapy.

Project 2: Epidemiological studies have demonstrated that there is a positive correlation between the inhalation of airborne particulate matter and increased morbidity and mortality due to respiratory and cardiovascular disease, especially in individuals with previous history of pulmonary dysfunction and/or cardiovascular disease and in the elderly.  However the molecular mechanism(s) by which these airborne particles, particularly ultrafine particles, exacerbate disease is unknown. This is due in part to the heterogeneity of the particles. This project being performed in collaboration with faculty in the Departments of Chemistry, Pathology and Veterinary Biosciences that is focused on determining the mechanism(s) by which small airborne particulates influence cardiopulmonary disease.  My role in the project, in addition to the genotoxicity studies, is in determining the relationship between oxidative stress (metal-based Fenton- chemistry and metal activation of xanthine oxidase), nitric oxide and vascular tone following exposure of cells (human endothelial) to synthetic particles

 

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