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Aqeilan, Rami I PhD

Research Assistant Professor

Department of Cancer Biology and Genetics

Contact Information

Office:

1088 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Ph. (614) 292-5906
E-Mail:  rami.aqeilan@osumc.edu

Research Interests:

Investigation of genetic and molecular basis of cancer development; study of genes (coding and non-coding) to elucidate pathways for developing rational, effective therapeutic approaches to cancer. Study of WW domain-containing oxidoreductase (WWOX) tumor suppressor gene, inactivated in most common human cancers.

Selected List of Publication (20 out of 68)

Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM: Functional association between wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A 2004;101:4401-4406.

Gaudio E, Palamarchuk A, Palumbo T, Trapasso F, Pekarsky Y, Croce CM, Aqeilan RI*: Physical association with wwox suppresses c-jun transcriptional activity. Cancer Res 2006;66:11585-11589.* Corresponding author.

Aqeilan RI*, Croce CM: Wwox in biological control and tumorigenesis. J Cell Physiol 2007;212:307-310.* Corresponding author.

Aqeilan RI*, Donati V, Gaudio E, Nicoloso MS, Sundvall M, Korhonen A, Lundin J, Isola J, Sudol M, Joensuu H, Croce CM, Elenius K: Association of wwox with erbb4 in breast cancer. Cancer Res 2007;67:9330-9336.* Corresponding author.

Aqeilan RI*, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM: Targeted deletion of wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A 2007;104:3949-3954.* Corresponding author.

Donati V, Fontanini G, Dell'Omodarme M, Prati MC, Nuti S, Lucchi M, Mussi A, Fabbri M, Basolo F, Croce CM, Aqeilan RI*: Wwox expression in different histologic types and subtypes of non-small cell lung cancer. Clin Cancer Res 2007;13:884-891.* Corresponding author.

Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM: The wwox tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem 2008;283:21629-21639.* Corresponding author.

Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM: Mir-15a and mir-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 2008;105:5166-5171.

Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, Munker R, Volinia S, Boccadoro M, Garzon R, Palumbo A, Aqeilan RI*, Croce CM*: Micrornas regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A 2008;105:12885-12890.* Corresponding author.

Sundvall M, Korhonen A, Paatero I, Gaudio E, Melino G, Croce CM, Aqeilan RI*, Elenius K*: Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced erbb4 isoforms. Proc Natl Acad Sci U S A 2008;105:4162-4167.* Corresponding author.

Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM: Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem 2008;283:13736-13744.

Abdeen S, Salah Z, Mally B, Smith Y, Tufail, R, Abu-Odeh M, Zanesi N, Croce CM, Nawaz Z, Aqeilan RI. Wwox inactivation enhances mammary tumorigenesis. Oncogene. 2011; 30(36):3900-6.

Drusco A, Pekarsky Y, Costinean S, Antenucci A, Conti L, Volinia S, Aqeilan RI, Huebner K, Zanesi N. Common fragile site tumor suppressor genes and corresponding mouse models of cancer. J Biomed Biotechnol. 2011;984-505.

Pichiorri F, Suh S-S., Rocci A, De Luca L,Taccioli C, Santhanam R, Wenchao Z, Benson Jr DM, Hofmainster C, Hansjuerg A, Garofalo M, Di Leva G, Volinia S, Lin H-J, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM. Down-regulation of p53-inducible microRNAs 192, 194 and 215 impairs the p53/MDM2 auto-regulatory loop in multiple myeloma development. Cancer Cell, 2010 Oct 19;18(4):367-81.

Volinia S, Galasso M, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Elena Sana M, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, et al. Reprogramming of miRNA networks in cancer and leukemia. Genome Research. 2010; 20(5):589-99.

Aqeilan RI*, Calin GA, Croce CM: Mir-15a and mir-16-1 in cancer: Discovery, function and future perspectives. Cell Death Differ 2010. 17(2):215-20. * Corresponding author.

Pichiorri F., De Luca l., Aqeilan RI. MicroRNAs: New players in Multiple Myeloma. Frontiers Genetics. 10.3389/fgene.2011.00022. Invited Review.

Gaudio E, Spizzo R, Paduano F, Luo Z, Efanov A, Palamarchuk A, Leber AS, Kaou M, Zanesi N, Bottoni A, Costinean S, Rassenti LZ, Nakamura T, Kipps TJ, Aqeilan RI, Pekarsky Y, Trapasso F, Croce CM. Tcl1 interacts with Atm and enhances NF-kB activation in hematological malignancies. Blood. 2011, 5;119(1):180-7.

Jones, KB., Salah. Z., Del Mare, S., Gaudio, E., Lovate, F., Nouvo, G., Glassco, M., Volinia, S., Stein, GS., Croce, CM., Lian, JB., Aqeilan, RI. (2012) MicroRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res. 2012, 1;72(7):1865-77.

Suh SS, Yoo JY, Nuovo GJ, Jeon YJ, Kim S, Lee TJ, Kim T, Bakàcs A, Alder H, Kaur B, Aqeilan RI, Pichiorri F, Croce CM. MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5316-21.