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Croce, Carlo

Professor and Chair

Department of Cancer Biology and Genetics

Contact Information:

Office:

1080 Biomedical Research Tower
460 W. 12th Ave.
COLUMBUS, OH 43210
Phone: 614-292-3063
Email: carlo.croce@osumc.edu

Education & Training

1969 Doctor of Medicine, University of Rome La Sapienza

Positions & Appointments

The Wistar Institute of Anatomy and Biology
1970- 1971 Associate Scientist, Philadelphia, PA
1971- 1974 Research Associate , Philadelphia, PA
1974- 1976 Associate Member , Philadelphia, PA
1976- 1980 Professor , Philadelphia, PA

The Carnegie Institution
1978- 1978 Sabbatical year in Don Brown's laboratory, Baltimore, MD

The National Institutes of Health
1979- 1983 Mammalian Genetics Study Section, Bethesda, MD

University of Pennsylvania
1980- 1988 Wistar Professor, Human Genetics, School of Medicine

The Wistar Institute of Anatomy and Biology
1980- 1988 Associate Director, Philadelphia, PA
1980- 1991 Institute Professor , Philadelphia, PA

Children?s Hospital of Philadelphia
1987- 1991 Wistar Professor, Pediatric Medicine, Philadelphia, PA

Temple University
1988- 1991 Director, Fels Institute for Cancer Research and Molecular Biology, School of Medicine 
1988- 1991 Professor, Department of Pathology, School of Medicine 
1988- 1991 Professor, Department of Medicine, School of Medicine 
1989- 1991 Chairman, Graduate Program in Molecular Biology and Genetics, School of Medicine

Thomas Jefferson University
1991- 2004 Director, Kimmel Cancer Institute/Kimmel Cancer Center , Medical College

The Ohio State University
2004-   The John W. Wolfe Chair, Human Cancer Genetics 
2004-   Director, Institute of Genetics 
2004-   Director, Human Cancer Genetics Program 
            Professor, Internal Medicine
            Chair, Molecular Virology, Immunology & Medical Genetics

Honors & Awards

1975 Research Career Development Award, The National Institutes of Health, Bethesda MD
 
1985 Outstanding Investigator Award,  National Institutes of Health, National Cancer Institute, Bethesda MD
 
1987 Scientific Award, American Cancer Society, Philadelphia Division
 
1990 Richard and Hinda Rosenthal Foundation Award, Association for Cancer Research
 
1992 Eagles Fly for Leukemia Lifetime Achievement Award
 
1992 Scanno Prize for Medicine
 
1992 Outstanding Investigator Award, National Institutes of Health, National Cancer Institute, Bethesda MD
 
1993 Charles S. Mott Prize, General Motors Cancer Research Foundation
 
1993 John Scott Award
 
1994 Robert J. and Claire Pasarow Foundation Cancer Award
 
1994 Honorary Member, Japanese Cancer Association
 
1995 CLAS Distinguished Scientist Award
 
1996 National Academy of Sciences
 
1997 Rudolf Virchow Honorary Lectureship, University of Wurzburg, Germany
 
1997 Scientific Excellence in Medicine Award, American-Italian Cancer Foundation
 
1997 The Twenty-Fifth Solomon A. Berson Memorial Lecture, Mt. Sinai School of Medicine, NY
 
1999 Raymond Bourgine Award and Gold Medal of Paris
 
1999 AACR-Pezcoller International Award for Cancer Research, American Association for Cancer Research
 
1999 Herz Memorial Lecture in Cancer Research, Tel Aviv University
 
2000 Doctor in Medicine, Honoris Causa, Uppsala University, Sweden
 
2000 Honor of Merit of Italian Republic
 
2001 Clavius Award for Achievement in Science and Research
 
2002 Rod and Ceil Mortel Lecture in Cancer Research, Penn State University
 
2003 Italian Gold Medal for Public Health, Presented by President Ciampi
 
2003 President of the Republic Prize, Accademia di Lincei
 
2003 Golgi Lecture, Accademia Nazionale dei Lincei
 
2003 Foreign Member, Accademia Nazionale delle Scienze, delta dei XL
 
2004 Premio Beccaria, A. Serra Foundation for Cancer Research
 
2005 Gottlieb Award, MD Anderson Cancer Center
 
2006 G.H.A. Clowes Memorial Award, American Association for Cancer Research 

2007 The iwCLL Binet-Rai-Medal for Outstanding Contribution to CLL Research

2007 The Henry M. Stratton Medal, American Society of Hematology (ASH)

2008 Albert Szent-Györgyi Prize for Progress in Cancer Research

2008 ARC Léopold Griffuel Prize for a Major Breakthrough in the Field of Cancer

2009 Maud L. Menten Endowed Lectureship, University of Pittsburgh

2009 Orrin Ingram Distinguished Lecture, Vanderbilt-Ingram Cancer Center

2010 The Ernst W. Bertner Memorial Award, The University of Texas M. D. Anderson Cancer Center

2010 Fellow of the American Academy of Arts and Sciences

2010 George and Lily Boxer Memorial Lecture, Robert Wood Johnson Medical School

2010 Annual Nickerson Memorial Lecture, McGill University, Montreal, Canada

2011 AMP Award for Excellence in Molecular Diagnostics 2011

2011 Fellow, American Association of Physicians

2011 Member, Institute of Medicine (IOM) of the National Academies

2011 AAAS Fellow, American Association for the Advancement of Science

2011 Weinman Foundation Innovation Fund Recipient, University of Hawaii Cancer Center

2012 Anthony Dipple Carcinogenesis Award, European Association of Cancer Research

2012 W. E. Keck Distinguished Lecture, W.E. Keck Center for Innovative Cancer Therapies, M. D.  Anderson Cancer Center


2012 Sebetia–Ter Award International Prize, Naples, Italy

2013 Foreign Member, Accademia delle Scienze dell’Istituto di Bologna, Bologna, Italy

2013 Recipient of the 2013 AACR Princess Takamatsu Memorial Lectureship, American Association   for Cancer Research

2013 Inaugural AACR Fellow of the Academy of the American Association for Cancer Research

2013 Health Prize of the Fund InBev-Baillet Latour, Leuven, Belgium

2013 The Eliezer Flescher Memorial Lecture, The Israeli Society for Cancer Research

2013 ICCNS – Springer Award, Nice France

2013 Juckett Distinguished Lecture – Vermont Cancer Center, University of Vermont

2013 Fellow of the National Academy of Inventors

2013 Distinguished Lecture – Frontiers in Oncology, Continuum Cancer Centers of New York and Beth  Israel St. Lukes-Roosevelt Medical Centers

2014 Chauncey D. and Elizabeth W. Leake 2014 Speaker Award

2014 Janet Rowley Memorial Lecture, American Association for Cancer Research, Philadelphia, PA

2015 Beckman Research Institute/Art Riggs Lectureship, City of Hope, Pasadena, CA

2015 Outstanding Investigator Award, National Cancer Institute

2016 Donald S. Coffey Lecturer, Soc. for Basic Urologic Research (SBUR) and the Soc. Of Urologic  Oncology (SUO) Joint Society Meeting, San Diego, CA

2017 Margaret Foti Award, American Association for Cancer Research (AACR)

Publications

For a full list of publications please visit The National Center for Biotechnology Information's PubMed website at http://www.ncbi.nlm.nih.gov/pubmed?term=Croce%20CM

Mundy-Bosse BL, Scoville SD, Chen L, McConnell K, Mao HC, Ahmed EH, Zorko N, Harvey S, Cole J, Zhang X, Costinean S, Croce CM, Larkin K, Byrd JC, Vasu S, Blum W, Yu J, Freud AG, Caligiuri MA. MicroRNA-29b Mediates altered innate immune development in acute leukemia. J Clin Invest. 2016 Dec 1;126(12):4404-4416. doi:10.1172/JCI85413. PMCID: PMC5127669.

Pozzo L, Vornoli A, Coppola I, Croce CM, Giorgetti L, Gervasi PG, Longo V. Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. Life Sci. 1;166:149-156, 2016. doi:10. 1016/j.lfs.2016.09.022. PubMed PMID: 27693527.

Ogasawara MA, Liu J, Pelicano H, Hammoudi N, Croce CM, Keating MJ, Huang P. Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53. Mitochondrion. 2016 Nov;31:33-39. doi: 10.1016/j.mito.2016.09.001. PMCID: PMC5108679.

Del Mare S, Husanie H, Iancu O, Abu-Odeh M, Evangelou K, Lovat F, Volinia S, Gordon J, Amir G, Stein J, Stein GS, Croce CM, Gorgoulis V, Lian JB, Aqeilan RI. WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma. Cancer Res., 76(20):6107-6117, 2016. PMCID: PMC5146760.

Justiniano SE, McElroy JP, Yu L, Yilmaz AS, Coombes KR, Senter L, Nagy R, Wakely P Jr, Volinia S, Vinco M, Giordano TJ, Croce CM, Saji M, Ringel MD. Genetic variants in thyroid cancer distant metastases. Endocr Relat Cancer. 23(10):L33-6, 2016. doi: 10.1530/ERC-16-0351. PMCID: PMC5026957.

Sattari A, Siddiqui H, Moshiri F, Ngankeu A, Nakamura T, Kipps TJ, Croce CM. Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias. Oncotarget. 7:54174-54182, 2016. PubMed PMID: 27527866.

Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J & Rai K. Chronic lymphocytic leukaemia. Nat Rev Dis Primers 3:16096 (2017), (PMCID pending)

Quintavalle C, Incoronato M, Puca L, Acunzo M, Zanca C, Romano G, Garofalo M, Iaboni M, Croce CM, Condorelli G.c-FLIPL enhances anti-apoptotic Akt functions by modulation of Csk3β activity.  Cell Death Differ. 2017 Jan 20. Doi: 10.1038/cdd.2017.7 [Epub ahead of print] PMID: 28106885.

Malpeli G, Barbi S, Zupo S, Tosadori G, Scardoni G, Bertolaso A, Sartoris S, Ugel S, Vicentini C, Fassan M, Adamo A, Krampera M, Scupoli MT, Croce CM, Scarpa A.  Identification of microRNAs implicated in the late differentiation stages of normal B cells suggests a central role for miRNA targets ZEB1 and TP53. Ocotarget. 2017 Jan 17. Doi: 10.18632/Oncotarget. 14683. [Epub ahead of print]  PMID: 28107180

Lee TJ, Yoo JY, Shu D, Li H, Zhang J, Yu JG, Jaime-Ramirez AC, Acunzo M, Romano G, Cui R, Sun HL, Luo Z, Old M, Kaur B, Guo P, Croce CM.  RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21. Mol Ther. 2017 Jan 18. pii: S1525-0016(16)45424-9. doi: 10.1016/j.ymthe.2016.11.016. [Epub ahead of print]  PMID: 28109960

Fattore L, Costantini S, Malpicci D, Ruggiero CF, Ascierto PA, Croce CM, Mancini R, Ciliberto G.  MicroRNAs in melanoma development and resistance to tarbet therapy.  Oncotarget.  2017 Jan 19. doi: 10.18632/oncotarget.14763 [Epub ahead of print].

Citron F, Armenia J, Franchin G, Polesel J, Talamini R, D'Andrea S, Sulfaro S, Croce CM, Klement W, Otasek D, Pastrello C, Tokar T, Jurisica I, French D, Bomben R, Vaccher E, Serraino D, Belletti B, Vecchione A, Barzan L, Baldassarre G.   An integrated approach identifies mediators of local recurrence in Head & Neck Squamous Carcinoma.  Clin Cancer Res. 2017 Feb 7. pii: clincanres.2814.2016. doi: 10.1158/1078-0432.CCR-16-2814. [Epub ahead of print]  PMID: 28174235

Zhou JK, Zheng Y-Z, Liu X-S, Gou Q, Ma R, Guo C-L, Croce CM, Liu L, Peng Y.  ROR1 expression as a biomarker for predicting prognosis in patients with Colorectal Cancer.  Submitted December 2016.

Argenio AD, Veronese A, Solimann S, Bassi C, Ferracin M, Lupini L, Elena S, Balatti V, Pepe F, Rassenti L, Innocenti I, Autore F, Mariani-Costantini R, Kipps TJ, Laurenti L, Negrini M, Croce CM and Visone R.  Longitudinal study of clonal evolution in untreated CLl patients with either stable or progressive disease.  Submitted January 2017.

Citron F, Armenia J, Franchin G, Polesel J, Talamini R, D’Andrea S, Sulfaro S, Croce CM, Klement W, Otasek D, PastrelloC, Tokar T, Jurisica I, French D, Bomen R, Vaccher E, Serraino D, Belletti B, Vecchione A, Barzan L, Baldassarre G.  An integrated approach identifies mediators of local recurrence in head and neck squamous carcinoma.  Clin Cancer Res. Feb 7. pii: clincanres.2814.2016. doi: 10.1158/1078-0432.CCR-16-2814. [Epub ahead of print]  PMID: 28174235

Moshiri F, Salvi A, Gramantieri L, Lampertico P, Guerrieo P, De Petro G, Bassi C, Lupine L, Sattari A, Cheung D, Veneziano D, Nigita G, Shankaraiah RC, Portolani N, Carcoforo P, Fornari F, Bolondi L, Frassoldati A, Sabbioni S, Colombo M, Croce CM, Negrini M.  Circulating microRNA-106b-3p as diagnostic biomarkers of hepatocellular carcinoma.  Cancer Lett., 388:320-327, 2016.  PMID: 28017893