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Croce, Carlo

Professor and Chair

Department of Cancer Biology and Genetics

Contact Information:


1080 Biomedical Research Tower
460 W. 12th Ave.
Phone: 614-292-3063
Email: carlo.croce@osumc.edu

Education & Training

1969 Doctor of Medicine, University of Rome La Sapienza

Positions & Appointments

The Wistar Institute of Anatomy and Biology
1970- 1971 Associate Scientist, Philadelphia, PA
1971- 1974 Research Associate , Philadelphia, PA
1974- 1976 Associate Member , Philadelphia, PA
1976- 1980 Professor , Philadelphia, PA

The Carnegie Institution
1978- 1978 Sabbatical year in Don Brown's laboratory, Baltimore, MD

The National Institutes of Health
1979- 1983 Mammalian Genetics Study Section, Bethesda, MD

University of Pennsylvania
1980- 1988 Wistar Professor, Human Genetics, School of Medicine

The Wistar Institute of Anatomy and Biology
1980- 1988 Associate Director, Philadelphia, PA
1980- 1991 Institute Professor , Philadelphia, PA

Children?s Hospital of Philadelphia
1987- 1991 Wistar Professor, Pediatric Medicine, Philadelphia, PA

Temple University
1988- 1991 Director, Fels Institute for Cancer Research and Molecular Biology, School of Medicine 
1988- 1991 Professor, Department of Pathology, School of Medicine 
1988- 1991 Professor, Department of Medicine, School of Medicine 
1989- 1991 Chairman, Graduate Program in Molecular Biology and Genetics, School of Medicine

Thomas Jefferson University
1991- 2004 Director, Kimmel Cancer Institute/Kimmel Cancer Center , Medical College

The Ohio State University
2004-   The John W. Wolfe Chair, Human Cancer Genetics 
2004-   Director, Institute of Genetics 
2004-   Director, Human Cancer Genetics Program 
            Professor, Internal Medicine
            Chair, Molecular Virology, Immunology & Medical Genetics

Honors & Awards

1975 Research Career Development Award, The National Institutes of Health, Bethesda MD
1985 Outstanding Investigator Award,  National Institutes of Health, National Cancer Institute, Bethesda MD
1987 Scientific Award, American Cancer Society, Philadelphia Division
1990 Richard and Hinda Rosenthal Foundation Award, Association for Cancer Research
1992 Eagles Fly for Leukemia Lifetime Achievement Award
1992 Scanno Prize for Medicine
1992 Outstanding Investigator Award, National Institutes of Health, National Cancer Institute, Bethesda MD
1993 Charles S. Mott Prize, General Motors Cancer Research Foundation
1993 John Scott Award
1994 Robert J. and Claire Pasarow Foundation Cancer Award
1994 Honorary Member, Japanese Cancer Association
1995 CLAS Distinguished Scientist Award
1996 National Academy of Sciences
1997 Rudolf Virchow Honorary Lectureship, University of Wurzburg, Germany
1997 Scientific Excellence in Medicine Award, American-Italian Cancer Foundation
1997 The Twenty-Fifth Solomon A. Berson Memorial Lecture, Mt. Sinai School of Medicine, NY
1999 Raymond Bourgine Award and Gold Medal of Paris
1999 AACR-Pezcoller International Award for Cancer Research, American Association for Cancer Research
1999 Herz Memorial Lecture in Cancer Research, Tel Aviv University
2000 Doctor in Medicine, Honoris Causa, Uppsala University, Sweden
2000 Honor of Merit of Italian Republic
2001 Clavius Award for Achievement in Science and Research
2002 Rod and Ceil Mortel Lecture in Cancer Research, Penn State University
2003 Italian Gold Medal for Public Health, Presented by President Ciampi
2003 President of the Republic Prize, Accademia di Lincei
2003 Golgi Lecture, Accademia Nazionale dei Lincei
2003 Foreign Member, Accademia Nazionale delle Scienze, delta dei XL
2004 Premio Beccaria, A. Serra Foundation for Cancer Research
2005 Gottlieb Award, MD Anderson Cancer Center
2006 G.H.A. Clowes Memorial Award, American Association for Cancer Research 


For current publications please visit The National Center for Biotechnology Information's PubMed website at http://www.ncbi.nlm.nih.gov/pubmed?term=Croce%20CM

Prasad, R; Yano, T; Sorio, C; Nakamura, T; Rallapalli, R; Gu, Y; Leshkowitz, D; Croce, C, M; Canaani, E. "Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia." Proceedings of the National Academy of Sciences of the United States of America. 92. 26 (1995) 12160-4.

Rasio, D; Negrini, M; Croce, C M. "Genomic organization of the ATM locus involved in ataxia-telangiectasia." Cancer research. 55. 24 (1995) 6053-7.

Fernandes-Alnemri, T; Takahashi, A; Armstrong, R; Krebs, J; Fritz, L; Tomaselli, K, J; Wang, L; Yu, Z; Croce, C, M; Salveson, G. "Mch3, a novel human apoptotic cysteine protease highly related to CPP32." Cancer research. 55. 24 (1995) 6045-52.

Schichman, S, A; Croce, C M. "Approaches to the identification and molecular cloning of chromosome breakpoints." Methods in enzymology. 254. (1995) 321-34.

Sorio, C; Mendrola, J; Lou, Z; LaForgia, S; Croce, C, M; Huebner, K. "Characterization of the receptor protein tyrosine phosphatase gene product PTP gamma: binding and activation by triphosphorylated nucleosides." Cancer research. 55. 21 (1995) 4855-64.

Rasio, D; Negrini, M; Manenti, G; Dragani, T, A; Croce, C M. "Loss of heterozygosity at chromosome 11q in lung adenocarcinoma: identification of three independent regions." Cancer research. 55. 18 (1995) 3988-91.

Narducci, M, G; Virgilio, L; Isobe, M; Stoppacciaro, A; Elli, R; Fiorilli, M; Carbonari, M; Antonelli, A; Chessa, L; Croce, C, M; Russo, G. "TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia." Blood. 86. 6 (1995) 2358-64.

Negrini, M; Cuneo, A; Nakamura, T; Baffa, R; Sabbioni, S; Alder, H; Castoldi, G; Croce, C M. "A novel t(9;11)(p22;q23) with ALL-1 gene rearrangement associated with progression of a myeloproliferative disorder to acute myeloid leukemia." Cancer genetics and cytogenetics. 83. 1 (1995) 65-70.

Negrini, M; Sabbioni, S; Ohta, M; Veronese, M, L; Rattan, S; Junien, C; Croce, C M. "Seven megabase yeast artificial chromosome contig at region 11p15: identification of a yeast artificial chromosome spanning the breakpoint of a chromosomal translocation found in a case of Beckwith-Wiedemann syndrome." Cancer research. 55. 13 (1995) 2904-9.

Canaani, E; Nowell, P, C; Croce, C M. "Molecular genetics of 11q23 chromosome translocations." Advances in cancer research. 66. (1995) 213-34.

Magdalinski, A; Drwinga, H; Crilley, P; Lasota, J; Brodsky, I; Croce, C, M; Nowell, P, C; Marks, D I. "Translocation 11;14 in newly diagnosed chronic myelogenous leukemia." Cancer genetics and cytogenetics. 81. 1 (1995) 24-7.

Baffa, R; Negrini, M; Schichman, S, A; Huebner, K; Croce, C M. "Involvement of the ALL-1 gene in a solid tumor." Proceedings of the National Academy of Sciences of the United States of America. 92. 11 (1995) 4922-6.

Haldar, S; Jena, N; Croce, C M. "Inactivation of Bcl-2 by phosphorylation." Proceedings of the National Academy of Sciences of the United States of America. 92. 10 (1995) 4507-11.

Veronese, M, L; Ohta, M; Finan, J; Nowell, P, C; Croce, C M. "Detection of myc translocations in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes." Blood. 85. 8 (1995) 2132-8.

Nagai, H; Negrini, M; Carter, S, L; Gillum, D, R; Rosenberg, A, L; Schwartz, G, F; Croce, C M. "Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer." Cancer research. 55. 8 (1995) 1752-7.

Cimino, G; Rapanotti, M, C; Elia, L; Biondi, A; Fizzotti, M; Testi, A, M; Tosti, S; Croce, C, M; Canaani, E; Mandelli, F. "ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age." Cancer research. 55. 8 (1995) 1625-8.

Yu, H; Diamandis, E, P; Levesque, M; Asa, S, L; Monne, M; Croce, C M. "Expression of the prostate-specific antigen gene by a primary ovarian carcinoma." Cancer research. 55. 8 (1995) 1603-6.

Yu, H; Diamandis, E, P; Monne, M; Croce, C M. "Oral contraceptive-induced expression of prostate-specific antigen in the female breast." The Journal of biological chemistry. 270. 12 (1995) 6615-8.

Bullrich, F; MacLachlan, T, K; Sang, N; Druck, T; Veronese, M, L; Allen, S, L; Chiorazzi, N; Koff, A; Heubner, K; Croce, C M. "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer." Cancer research. 55. 6 (1995) 1199-205.

Schichman, S, A; Canaani, E; Croce, C M. "Self-fusion of the ALL1 gene. A new genetic mechanism for acute leukemia." JAMA : the journal of the American Medical Association. 273. 7 (1995) 571-6.

Leshkowitz, D; Rozenblatt, O; Nakamura, T; Yano, T; Dautry, F; Croce, C, M; Canaani, E. "ALL-1 interacts with unr, a protein containing multiple cold shock domains." Oncogene. 13. 9 (1996) 2027-31.

Veronese, M, L; Schichman, S, A; Croce, C M. "Molecular diagnosis of lymphoma." Current opinion in oncology. 8. 5 (1996) 346-52.

Condorelli, G, L; Facchiano, F; Valtieri, M; Proietti, E; Vitelli, L; Lulli, V; Huebner, K; Peschle, C; Croce, C M. "T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice." Cancer research. 56. 22 (1996) 5113-9.

Yu, H; Diamandis, E, P; Levesque, M; Giai, M; Roagna, R; Ponzone, R; Sismondi, P; Monne, M; Croce, C M. "Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue." Breast cancer research and treatment. 40. 2 (1996) 171-8.

Bullrich, F; Veronese, M, L; Kitada, S; Jurlander, J; Caligiuri, M, A; Reed, J, C; Croce, C M. "Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia." Blood. 88. 8 (1996) 3109-15.

Bullrich, F; Fernandes-Alnemri, T; Litwack, G; Alnemri, E, S; Croce, C M. "Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3." Genomics. 36. 2 (1996) 362-5.

Vorechovsky, I; Luo, L; Lindblom, A; Negrini, M; Webster, A, D; Croce, C, M; Hammarstrom, L. "ATM mutations in cancer families." Cancer research. 56. 18 (1996) 4130-3.

Barnes, L, D; Garrison, P, N; Siprashvili, Z; Guranowski, A; Robinson, A, K; Ingram, S, W; Croce, C, M; Ohta, M; Huebner, K. "Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase." Biochemistry. 35. 36 (1996) 11529-35.

Virgilio, L; Shuster, M; Gollin, S, M; Veronese, M, L; Ohta, M; Huebner, K; Croce, C M. "FHIT gene alterations in head and neck squamous cell carcinomas." Proceedings of the National Academy of Sciences of the United States of America. 93. 18 (1996) 9770-5.

Bigoni, R; Negrini, M; Veronese, M, L; Cuneo, A; Castoldi, G, L; Croce, C M. "Characterization of t(11;14) translocation in mantle cell lymphoma by fluorescent in situ hybridization." Oncogene. 13. 4 (1996) 797-802.

Negrini, M; Monaco, C; Vorechovsky, I; Ohta, M; Druck, T; Baffa, R; Huebner, K; Croce, C M. "The FHIT gene at 3p14.2 is abnormal in breast carcinomas." Cancer research. 56. 14 (1996) 3173-9.

Singh, A, D; Croce, C, M; Wary, K, K; Shields, J, A; Donoso, L, A; Shields, C, L; Huebner, K; Ohta, M. "Familial uveal melanoma: absence of germline mutations involving the cyclin-dependent kinase-4 inhibitor gene (p16)." Ophthalmic genetics. 17. 1 (1996) 39-40.

Kastury, K; Baffa, R; Druck, T; Ohta, M; Cotticelli, M, G; Inoue, H; Negrini, M; Rugge, M; Huang, D; Croce, C, M; Palazzo, J; Huebner, K. "Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines." Cancer research. 56. 5 (1996) 978-83.

Veronese, M, L; Bullrich, F; Negrini, M; Croce, C M. "The t(6;16)(p21;q22) chromosome translocation in the LNCaP prostate carcinoma cell line results in a tpc/hpr fusion gene." Cancer research. 56. 4 (1996) 728-32.

Sozzi, G; Alder, H; Tornielli, S; Corletto, V; Baffa, R; Veronese, M, L; Negrini, M; Pilotti, S; Pierotti, M, A; Huebner, K; Croce, C M. "Aberrant FHIT transcripts in Merkel cell carcinoma." Cancer research. 56. 11 (1996) 2472-4.

Ohta, M; Berd, D; Shimizu, M; Nagai, H; Nagai, H; Mastrangelo, M; Shields, J, A; Shields, C, L; Croce, C, M; Huebner, K. "Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma." International journal of cancer. Journal international du cancer. 65. 6 (1996) 762-7.

Caligiuri, M, A; Strout, M, P; Schichman, S, A; Mrozek, K; Arthur, D, C; Herzig, G, P; Baer, M, R; Schiffer, C, A; Heinonen, K; Knuutila, S; Nousiainen, T; Ruutu, T; Block, A, W; Schulman, P; Pedersen-Bjergaard, J; Croce, C, M; Bloomfield, C D. "Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11." Cancer research. 56. 6 (1996) 1418-25.

Haldar, S; Chintapalli, J; Croce, C M. "Taxol induces bcl-2 phosphorylation and death of prostate cancer cells." Cancer research. 56. 6 (1996) 1253-5.

Fidanza, V; Melotti, P; Yano, T; Nakamura, T; Bradley, A; Canaani, E; Calabretta, B; Croce, C M. "Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro." Cancer research. 56. 6 (1996) 1179-83.

Rasio, D; Schichman, S, A; Negrini, M; Canaani, E; Croce, C M. "Complete exon structure of the ALL1 gene." Cancer research. 56. 8 (1996) 1766-9.

Sozzi, G; Veronese, M, L; Negrini, M; Baffa, R; Cotticelli, M, G; Inoue, H; Tornielli, S; Pilotti, S; De Gregorio, L; Pastorino, U; Pierotti, M, A; Ohta, M; Huebner, K; Croce, C M. "The FHIT gene 3p14.2 is abnormal in lung cancer." Cell. 85. 1 (1996) 17-26.

Ohta, M; Inoue, H; Cotticelli, M, G; Kastury, K; Baffa, R; Palazzo, J; Siprashvili, Z; Mori, M; McCue, P; Druck, T; Croce, C, M; Huebner, K. "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers." Cell. 84. 4 (1996) 587-97.

Baffa, R; Negrini, M; Mandes, B; Rugge, M; Ranzani, G, N; Hirohashi, S; Croce, C M. "Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach." Cancer research. 56. 2 (1996) 268-72.

Brenner, C; Pace, H, C; Garrison, P, N; Robinson, A, K; Rosler, A; Liu, X, H; Blackburn, G, M; Croce, C, M; Huebner, K; Barnes, L D. "Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein." Protein engineering. 10. 12 (1997) 1461-3.

Vitale, M; Zauli, G; Bassini, A; Visani, G; Rezzani, R; Croce, C, M; Manzoli, F A. "Selective enrichment in human megakaryocyte progenitors by the B203.13 surface differentiation antigen." British journal of haematology. 99. 4 (1997) 766-9.

Monaco, C; Negrini, M; Sozzi, G; Veronese, M, L; Vorechovsky, I; Godwin, A, K; Croce, C M. "Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23." Genomics. 46. 2 (1997) 217-22.

Inoue, H; Ishii, H; Alder, H; Snyder, E; Druck, T; Huebner, K; Croce, C M. "Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion." Proceedings of the National Academy of Sciences of the United States of America. 94. 26 (1997) 14584-9.

Narducci, M, G; Stoppacciaro, A; Imada, K; Uchiyama, T; Virgilio, L; Lazzeri, C; Croce, C, M; Russo, G. "TCL1 is overexpressed in patients affected by adult T-cell leukemias." Cancer research. 57. 24 (1997) 5452-6.

Siprashvili, Z; Sozzi, G; Barnes, L, D; McCue, P; Robinson, A, K; Eryomin, V; Sard, L; Tagliabue, E; Greco, A; Fusetti, L; Schwartz, G; Pierotti, M, A; Croce, C, M; Huebner, K. "Replacement of Fhit in cancer cells suppresses tumorigenicity." Proceedings of the National Academy of Sciences of the United States of America. 94. 25 (1997) 13771-6.

Sozzi, G; Tornielli, S; Tagliabue, E; Sard, L; Pezzella, F; Pastorino, U; Minoletti, F; Pilotti, S; Ratcliffe, C; Veronese, M, L; Goldstraw, P; Huebner, K; Croce, C, M; Pierotti, M A. "Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities." Cancer research. 57. 23 (1997) 5207-12.