Ohio State Navbar

Sign In

Fishel, Richard

Professor

Department of Cancer Biology and Genetics

Contact Information:

Office:

1016 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210
Phone: 614-292-2484
E-mail: rfishel@osu.edu

Lab:

1042 Biomedical Research Tower
Phone: (614) 688-4430
Website


Field of Research:

The Biophysical Mechanisms, Genetics, Regulation, and Consequences of DNA Repair and Genome Rearrangement in Human Cells


Education and Training:

1976  B.S.       Biology (Honors), University of California, Irvine, California

1980  Ph.D.     Molecular Biology and Biochemistry, University of California
1980-1984       Postdoc, Biological Chemistry, Harvard Medical School, Boston, MA
1984-1986       Medicine, Molecular Medicine Program, Harvard Medical School, Boston, MA
 

Academic Appointments:

 1980 ‑ 1984     Daymon-Runyon / Walter Winchell & NIH / NRSA Postdoctoral Fellow, Dana‑Farber
                            Cancer Institute and Harvard Medical School Boston, Massachusetts

1984 ‑ 1986     Assistant Professor, Molecular Medicine Program, Department of Medicine, Harvard
                            Medical School  and Beth Israel Hospital, Boston, Massachusetts  

1986 ‑ 1991      Head, Genetic Recombination and Repair Group, National Cancer Institute, Maryland
 
1991 - 1996       Associate Professor / Professor of Microbiology and Molecular Genetics, University of 
                               Vermont Medical School, Burlington, Vermont
 
1996 - 2004       Professor of Microbiology and Immunology, Head of the Genetics and Molecular Biology 
                                Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 
 
2004 - present   Professor and Vice Chair of Molecular Virology, Immunology, and Medical Genetics; Human
                               Genetics Institute, The Ohio State University Medical Center and Comprehensive Cancer
                               Center, Columbus, Ohio

2009 - present   Professor of Physics, The Ohio State University, Columbus, Ohio
 

Awards and Honor

Herrera Memorial Award and Lecture, HNPCC/Collaborative Group of America - 2009
American Cancer Society Award for Basic Science Research – 2002
The P. Meera Khan Memorial Award and Lecture – Second Joint Leeds Polyposis Group / International Collaborative Group for HNPCC – 1999
Nigro Award Lecture, American Association of Colorectal Surgeons, 1997 and 2002
New Investigator Research Award, National Cancer Institute, 1984-1986
National Service Award, National Institutes of Health, 1981-1983
Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellowship, 1980-1981
American Cancer Society Fellowship Award, 1980 (declined)
DHEW, PHS Predoctoral Traineeship, 1976-1980
Graduate with Honors in Biological Science, University of California, Irvine, 1976
NIH Summer Research Assistant, University of California, Irvine, 1975


Editorial and Advisory Boards:

External Advisory Board, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 

   2014 - present
Member, Molecular Genetics B Study Section, 2011 – present
Program Review Committee, National Institute of Environmental and Health Sciences, 2007
Scientific Advisory Board, IntergraGen, 2001 - present
Editorial Board, DNA Repair, 2001 – present
Editorial Board, Cancer Biology and Therapy, 2000 – present
Editorial Board, Cancer Research, 2001 – 2006; 2009 – present
NCI Legislative Advisory Committee, 2000
Scientific Advisor – Cancer Genetics, Lexicon Genetics, 1999 - 2002
Member, Career Development Awards Subcommittee - Leukemia Society of America - 1999-2004
Editorial Board, Protein Expression and Purification, Academic Press, 1990 - 2003
Referee, Biological Sciences Section, NSF, 1986 - 1988
Referee, Biophysical Chemistry Study Section, NIH, 1991
Member, Radiation Study Section, DOE, 1991
Member, Physiological Chemistry Study Section (ad hoc), NIH, 1993
Member, Biochemistry Study Section; Molecular Genetics A (ad hoc), NIH, 1993; 2008
Member, Radiation Study Section, NIH, 1994-1999
Member, National Institute of Neurological Disorders and Stroke Site Visit Team, NIH, 1994
Member, Mammalian Genetics Study Section (ad Hoc), NIH, 1994
Member, RFA Consultation Panel, Radiation Effects Branch, NCI, 1995
Member, Study Section Reviewer Reserve, NIH, 1996 – present
 

Selected Publications:

For a complete list of publications please visit the National Institutes of Health PubMed site at: PubMed.gov

Mazurek,  T., C.N. Johnson, M.W. Germann, and R. Fishel.  2009.  The Sequence Context Effect for hMSH2-hMSH6 Mismatch-Dependent Activation.  Proc. Nat. Acad. Sci (USA) 106:4177-4182.

Su, X., N.K. Jacob, R. Amunugama, P-H. Hsu, R. Fishel, and M.A. Freitas.  2009.  Enrichment and characterization of histones by 2D-hydroxylapatite/reverse-phase liquid chromatography mass spectrometry.  Anal. Biochem.  388:47-55

Charbonneau, N., R. Amunugama, C. Schmutte, K Yoder, and R. Fishel.  2009.  Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.  Cancer Biol. and Therapy. 14:1411-1420

Manohar, M., A.M. Mooney, J. North, R.J. Nakkula, J.W. Picking, A. Edon, R. Fishel, M.G. Poirier, and J.J. Ottesen.  2009.  Acetylation of Histone H3 at the nucleosome dyad alters DNA-histone binding.  J. Biol. Chem.  284: 23312-23321

Wang, J., N.K. Jacob, K.J. Ladner, A. Beg, J.D. Perko, S.M. Tanner, S. Liyanarachchi, R. Fishel, and D.C Guttridge.  2009.  RelA/p65 functions to maintain cellular senescence by regulating genomic stability.  EMBO Reports.  10:1272-1278
 
Li, L.S., J. C. Morales, M. Veigl, D. Sedwick, S. Greer, M. Meyers, M. Wagner, R. Fishel, and D.A. Boothman.  2009.   DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new ‘drugable’ targets.  Brit J. Pharmacol  158:679-692
 
Javaid, S., M. Manohar, N. Punja, A. Mooney, J. Ottesen, M. Poirier, and R. Fishel.  2009. Nucleosome remodeling by hMSH2-hMSH6.  Molecular Cell.  36:1086-1094.
 
Resnick, K. E., H. Hampel, R. Fishel, and D.E. Cohn.  2009. Current and emerging trends in Lynch syndrome identification in women with endometrial cancer.  Gynecol Oncol.  144:128.134
 
Valeri, N., P. Gasparini, M. Fabbri, C. Braconi, A. Veronese, F. Lovat, B. Adair, I. Vannini, F. Fanini, A. Bottoni, S. Costinean, S.K. Sandhu, G.J. Nuovo, H. Alder, R. Gafa, F. Calore, M. Ferracin, G. Lanza, S. Volinia, M. Negrini, M.A. McIlhatton, D. Amadori, R. Fishel and C. M. Croce.  2010.  Modulation of mismatch repair and genomic stability by miR-155.  Proc. Nat. Acad. Sci. (USA). 107: 6982-6987.
 
Park, J., Y.-M. Jeon, D. In, R. Fishel, C. Ban, and J.-B. Lee.  2010.  Single molecule analysis reveals the kinetics and physiological relevance of MutL ssDNA binding.  PLoS One.  5:e1549.
 
Valeri, N., P. Gasparini, C. Braconi, A. Paone, F. Lovat, M. Fabbri, D. Amadori, H. Alder1, G.J Nuovo, R. Fishel and C.M. Croce.  2010.  miR21 induces resistance to 5-Fluorouracil  by down-regulating MSH2.  Proc. Nat. Acad. Sci. (USA).  107: 21098-21103
 
Jeong, C., W.-K. Cho, K.-M. Song, C. Cook, T.-Y. Yoon, C. Ban, R. Fishel, J.-B. Lee.  2011.  MutS switches between two fundamentally distinct clamps during mismatch repair.  Nat. Struct. Mol. Biol.  18: 379-385
 
Yoder, K.E., W. Roddick, P. Hoellerbauer, and R. Fishel.  2011.  The TFIIH proteins XPB and XPD participate in retroviral cDNA degradation in the nuclear compartment.  Virology.  410: 291-298.
 
Yoder, K.E., A. Espeseth, M.T. Russo, R.S. Lloyd, D. Hazuda, R.W. Sobol, and R. Fishel.  2011.  The host base excision repair pathway is required for efficient lentivirus integration.  PLoS One.  6:e17862
 
Espeseth, A.S., R. Fishel, D. Hazuda, Q. Huang, M. Xu, K.E. Yoder, and H. Zhou (alphabetical order).  2011. siRNA Screening of a targeted library of DNA repair factors reveals a role for base excision repair in HIV infection.  PLoS One.  6: e17612
 
Pabla, N., Z. Ma, M. McIlhatton, R. Fishel, and Z. Dong.  2011.  hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.  J. Biol. Chem.  286: 10411-10408.
 
McIlhatton, M.A., J. Tyler, L.A. Kerepesi, T. Bocker-Edmonston, M.H. Kucherlapati, W. Edelmann, R. Kucherlapati, L. Kopelovich and R. Fishel.  2011.  Aspirin and Low Dose Nitric Oxide-Donating Aspirin Increase Life Span in a Lynch Syndrome Mouse Model.  Cancer Prev. Res.  4:684-93.
 
North, J.A., S. Javaid, M. Ferdinand, N. Chatterjee, J. Picking, M. Shoffner, R.J. Nakkula, B. Bartholomew, J.J. Ottesen, R. Fishel and M.G. Poirier.  2011.  Histone H3(T118) phosphorylation switches the mechanism of SWI/SNF nucleosome remodeling.  Nucl. Acids Res.  39:6465-6474.
 
Simon, M., J. Shimko. R. Fortes, M. Ferdinand, M. Manohar, M. Zhang, R. Fishel, J.J. Ottesen and M.G. Poirier.  2011.  Histone modification modules control nucleosome disassembly.  Proc. Nat. Acad. Sci, (USA).  108:12711-6
 
Amunugama, R. and R. Fishel.  2011.  Subunit interface residues F129 and H294 of Human RAD51 are essential for recombinase function.  PLoS One.  6:e23071.
 
Fortes, R.A., J.A. North, S. Javaid, O.P. Tabbaa, R. Fishel, M.G. Poirier and R. Bundschuh.  2011.  A quantitative model of nucleosome dynamics and applications to hMSH2-hMSH6 nucleosome disassembly.  Nucl. Acids Res.  39: 8306-8013
 
Heinen, C.D., J.L. Cyr, C. Cook, N. Punja, M. Sakato, J.V. Martín-López, M. Hingorani, and R. Fishel.  2011.  hMSH2 controls ATP processing by hMSH2-hMSH6.  J. Biol. Chem.  286:40287-40295.
 
Amunugama, R., Y. He, S. Wilcox, R. Fortes, R. Bundschuh, K.-S. Shim, Y. Luo, J. Griffith, and R. Fishel.  2012.  The RAD51 ATP cap regulates nucleoprotein filament stability.  J. Biol. Chem.  287:8724-36
 
Cho, W–K., C. Jeong, D–H. Kim, M. Jang, K–M. Song, J. Hanne, C. Ban, R. Fishel, J–B. Lee.  2012.  ATP alters the diffusion mechanism of MutS on mismatched DNA.  Structure.  20:1264-1274
 
Martín-López, J.V., Y. Barrios, V. Medina-Arana, M. Andújar, S. Lee, L. Gu, G-M. Li, J. Rüschoff, E. Salido and R. Fishel.  2012.  Functional Analysis of the hMSH2(M688R) Lynch Syndrome Mutation:  a novel tissue-specific dominant negative.  Carcinogenesis.  33:1647-1654.
 
North, J.A., J.C. Shimko, S. Javaid, A.M. Mooney, M.A. Shoffner, S.D. Rose, R. Bundschuh, R. Fishel, J. Ottesen, and M. Poirier.  2012.  Regulation of the nucleosome unwrapping rate controls DNA accessibility.  Nucl. Acids Res.  40:10215-10227.
 
Amunugama, R., and R. Fishel.  2012.  Homologous Recombination in Eukaryotes.  In: Prog Mol Biol Transl Sci.  (Doetsch, Ed).  110:155-206
North, J.A., R. Amunugama, W-D. Heyer, M. Poirier and R. Fishel.  2013.  ATP-dependent nucleosome unwrapping catalyzed by human RAD51.  Nucl. Acids Res. 41:7302-7312.
 
Amunugama, R., J. Groden and R. Fishel.  2013. The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament. DNA Repair. 9:723-732.
 
Hanne, J., J. Liu, J-.B. Lee and R. Fishel.  2013.  Single-molecule FRET studies on DNA mismatch repair.  Int. J. Biophys.  3:18-38.
 
Martín-López, J.V., and R. Fishel.  2013.  Understanding Lynch Syndrome:  the mechanism of mismatch repair. Familial Cancer 12:159-168.
 
Honda, M., Y. Okuno, S.R. Hengel, J.V. Martin-Lopez, C.P. Cook, R. Amunugama, R. Soukup, S. Subramanyam, R. Fishel and M. Spies.  2014.  hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate.  Proc. Nat. Acad. Sci. (USA).  111:E316-25.
 
Lee, J-.B., W-.K. Cho, J. Park, D. Kim, S.H. Lee, and R. Fishel.  2014.  Single molecule views of MutS on mismatched DNA.  DNA Repair.  20:82-93.
 
Spies, M., and R. Fishel.  2014.  Mismatch repair during homologous and homeologous recombination.  In: Recombination Mechanism (Kowalczykowski and Heyer, Ed.)  Cold Spring Harbor Press.  (in press).
 
Fishel, R., and J,-B. Lee.  2014.  Mismatch Repair.  In: DNA Replication, Recombination and Repair : Molecular Mechanisms and Pathology (Hanaoka and Sugasawa, Ed.)  Springer, NY ( in press)