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Strohecker, Anne M PhD

Assistant Professor​

Department of Cancer Biology and GeneticsStrohecker.png

Joint Appointment

 
Molecular, Cellular and Development Biology

 
 

Contact Information

  Office: 514 Biomedical Research Tower
  460 W. 12th Ave.
  Columbus, Oh 43210
  Tel: 614-685-9252
  Email: anne.strohecker@osumc.edu

 

Research Interests

We are interested in mechanisms of autophagy regulation, with a focus on discovering how to modulate the pathway for optimal therapeutic benefit. Autophagy is a highly conserved pathway that recycles cellular components to maintain homeostasis and support metabolism, ensuring survival of the organism. Deregulation of autophagy has important consequences for aging, innate immunity, neurodegenerative diseases, and cancer although we have an incomplete understanding of how the pathway is regulated. We use a combination of cell culture, genetically engineered mouse models, microscopy, and loss of function screening as tools to identify novel regulators of the autophagy pathway. 


 

Selected Publications

  1. Bill KL, Casadei L, Prudner BC, Iwenofu H, Strohecker AM, Pollock RE.  Liposarcoma: molecular targets and therapeutic implications. Cell Mol Life Sci. 2016 Oct;73(19):3711-8. doi:10.1007/s00018-016-2266-2. Epub 2016 May 12. PMID:27173057
  2. Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.  Oncogene. 2015 Nov 5;34(45):5662-76. doi: 10.1038/onc.2015.23. Epub 2015 Mar 16. PMID:15772235
  3. Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov. 2016 Jul;4(7):766-72. doi: 10.1158/2159-8290. CD-14-0196. Epub 2014 May 23. PMID 24860158
  4. Strohecker AM, White E. Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy. 2014 Feb;10(2):384-5. doi: 10.4161/auto.27320. Epub 2013 Dec 17. PMID:24362353
  5. Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Matthew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.  Cancer Discov. 2013 Nov;8(11):1272-85. doi: 10.1158-2159-8290. CD-13-0397. Epub 2013 Aug 21. PMID 23965987
  6. Guo JY, Karsli-Uzunbag G, Matthew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013 Jul 1; 27(13):1447-61. doi:10.1101/gad.219642.113. PMID: 23824538
  7. Guo JY, Chen HY, Matthew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011 Mar 1;25(5):460-70. doi: 10.1101/gad.2016311. Epub 2011 Feb 11. PMID: 21317241
  8. White E, Karp C, Strohecker AM, Guo Y, Matthew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol. 2010 Apr;22(2):212-7. doi: 10.1016/j.ceb.2009.12.008. Epub 2010 Jan 6. PMID 20056400
  9. Strohecker AM, Yehiely F, Chen F, Cryns VL. Caspase cleavage of HER-2 releases a Bad-like cell death effector. J Biol Chem. 2008 June 27;283(26):18269-82. doi: 10.1074/jbc.M802156200. Epub 2008 Apr 17. PMID: 18420586
  10. Lu M*, Strohecker A*, Chen F, Kwan T, Bosman J, Jordan VC, Cryns VL. Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin Cancer Res. 2008 May 15;14(10:3168-76. doi: 10.1158/1076-0432.CCR-07-4362
  11. Dusek RL, Godsel LM, Chen F, Strohecker AM, Getsios S, Harmon R,Muller EJ, Caldelari R, Cryns VL, Green KJ. Plakoglobin deficiency protects keratinocytes from apoptosis. J Invest Dermatol. 2007 Apr;127(4):792-801. Epub 2006 Nov 16. PMID: 17110936