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Symer, David MD, PhD

Assistant Professor   

Departments of Cancer Biology and Genetics,Human Cancer Genetics Program, Internal Medicine,and Biomedical Informatics,The Ohio State University Comprehensive Cancer Center.

Contact Information:


Tzagournis Research Facility, Room 440
420 West 12th Avenue

Columbus, Ohio 43210
Ph. (614) 292 0885
Fax. (614) 292 6108
Lab (614) 292 6486
E-Mail: david.symer@osumc.edu

Research Interests

The Symer research group works to identify and characterize the molecular genetics mechanisms underlying both natural variation and the formation of diseases in humans and mice. Lab members use complementary genetic and genomic approaches to study the functional consequences of endogenous mammalian retrotransposons, exogenous viruses and aberrant RNA splicing, each of which can drive extensive genomic, transcriptional, and phenotypic diversity and disease formation. They develop and use state-of-the-art techniques and assays using conventional and next generation sequencing, exon microarrays, mouse models, and bioinformatics tools. The Symer laboratory’s molecular and bioinformatics work has resulted in entirely new insights into the molecular basis for natural variation and into the molecular pathogenesis of diseases including certain cancers in human and mouse. 

Selected Publications:

Hertlein E, Beckwith KA, Lozanski G, Chen TL, Towns WH, Johnson AJ, Lehman A, Ruppert AS, Bolon B, Andritsos L, Lozanski A, Rassenti L, Zhao W, Jarvinen TM, Senter L, Croce CM, Symer DE, de la Chapelle A, Heerema NA, Byrd JC: Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease.  PLoS One. 2013 Oct 9;8(10):e76607.

He, H., Bronisz, A., Liyanarachchi, S., Nagy, R., Li, W., Huang, Y., Akagi, K., Saji, M., Kula, D., Wojcicka, A., Sebastian, N., Wen, B., Puch, Z., Kalemba, M., Stachlewska, E., Czetwertynska, M., Dlugosinska, J., Dymecka, K., Ploski, R., Krawczyk, M., Morrison, P. J., Ringel, M. D., Kloos, R. T., Jazdzewski, K., Symer, D. E., Vieland, V. J., Ostrowski, M., Jarzab, B., de la Chapelle, A. SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. J Clin Endocrinol Metab. 98(5):E973-80, 2013 (doi: 10.1210/jc.2012-3823).
He, H., Li, W., Wu, D., Nagy, R., Liyanarachchi, S., Akagi, K., Jendrzejewski, J., Jiao, H., Hoag, K., Wen, B., Srinivas, M., Waidyaratne, G., Wang, R., Wojcicka, A., Lattimer, I. R., Stachlewska, E., Czetwertynska, M., Dlugosinska, J., Gierlikowski, W., Ploski, R., Krawczyk, M., Jazdzewski, K., Kere, J., Symer, D. E., Jin, V., Wang, Q., de la Chapelle, A. Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance. PLoS ONE 8(5): e61920. doi:10.1371/journal.pone.0061920, 2013.
Akagi, K., Li, J., Broutian, T., Padilla-Nash, H., Wangsa, D., Xiao, W., Jiang, B., Rocco, J., Teknos, T. N., Kumar, B., Wangsa, D., He, D., Ried, T., Symer, D. E.,+ Gillison, M. L.+ Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Research, accepted for publication, 2013.   +    joint corresponding senior authors

Akagi, K., Li, J., and Symer, D: how do mammalian transposons induce genetic variation? A conceptual framework.  BioEssays online publication January 14, 2013. doi: 10.1002/bies.201200133

Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J. R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J. R., Mullikin, J. C., Meader, S. J., Ponting, C. P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoç, E., Alkan, C., Sajjadian, S., Catacchio, C. R., Ventura, M., Marques-Bonet, T., Eichler, E. E., André, C., Atencia, R., Mugisha, L., Patterson, N., Siebauer, M., Good, J. M., Fischer, A., Ptak, S. E., Lachmann, M., Symer, D. E., Mailund, T., Schierup, M. H., Andrés, A. M., Kelso, J., Pääbo, S. The bonobo genome compared with the genomesof chimpanzee and human. Nature 426:527-531, 2012 doi:10.1038/nature11128

Li, J., Akagi, K., Hu, Y., Trivett, A. L., Hlynialuk, C. J. W., Swing, D. A., Volfovsky, N., Morgan, T. C., Golubeva, Y., Stephens, R. M., Smith, D. E., and Symer, D. E. Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance. Genome Res. 22:870-884, 2012 doi:10.1101/gr.130740.111

Billington C.J. Jr, Ng B., Forsman C., Schmidt B., Bagchi A., Symer D.E., Schotta G., Gopalakrishnan R., Sarver A.L., Petryk A. The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice. Dev Biol. 355: 21-31, 2011. 

He H., Liyanarachchi S., Akagi K., Nagy R., Li J., Dietrich R.C., Li W., Sebastian N., Wen B., Xin B., Singh J., Yan P., Alder H., Haan E., Wieczorek D., Albrecht B., Puffenberger E., Wang H., Westman J.A., Padgett R.A., Symer D.E., de la Chapelle A. Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science. 332: 238-40, 2011.

Akagi K., Stephens R.M., Li J., Evdokimov E., Kuehn M.R., Volfovsky N., Symer D.E. MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains. Nucleic Acids Res. 38: D600-6, 2010.

Schneider A.M., Duffield A.S., Symer D.E., Burns K.H. Roles of retrotransposons in benign and malignant hematologic disease. Cellscience. 6: 121-145, 2009.Agarwal, Y., Koch, W. M., Xiao, W., Westra, W., Trivett, A. L., Symer, D. E., and Gillison, M. L. Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin. Canc. Res. 14: 7143-7150, 2008.

Van Duyne, R., Easley, R., Wu, W., Berro, R., Pedati, C., Klase, Z., Kehn-Hall, K., Flynn, E. K., Symer, D. E., and Kashanchi, F. (2008) Lysine methylation of HIV-1 Tat decreases transcriptional activation of the viral LTR. Retrovirology 5: 40 doi:10.1186/1742-4690-5-40, 2008.

Akagi, K., Li, J., Stephens, R.M., Volfovsky, N. and Symer, D.E.: Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Genome Research 18: 869-880, 2008.

*Symer, D.E., Connelly, C., Szak, S.T., Caputo, E.M., Cost, G.J., Parmigiani, G. and Boeke, J. D.: Human L1 retrotransposition is associated with genetic instability in vivo. Cell 110: 327-338, 2002. *cover article

Gillison, M.L., Koch, W., Capone, R.B., Spafford, M., Westra, W., Wu, L., Daniel, R., Symer D.E., Shah, K.V. and Sidransky, D.: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J. Natl. Can. Inst. 92: 709-720, 2000.

Reim, J., Symer, D.E., Watson, D.C., Dintzis, R.Z. and Dintzis, H.M.: Low molecular weight antigen arrays delete high affinity memory B cells without affecting specific T cell help. Mol. Immunol. 33: 1377-1388, 1996.

Symer, D.E., Reim, J., Dintzis, R.Z., Voss, E.W., Jr., and Dintzis, H.M.: Durable elimination of high affinity, T cell-dependent antibodies by low molecular weight antigen arrays in vivo. J. Immunol. 155: 5608-5616, 1995.

Dintzis, H.M., Symer, D.E., Dintzis, R.Z., Zawadzke, L.E., and Berg, J.M.: A comparison of the immunogenicity of a pair of protein enantiomers. Proteins. 16: 306-308, 1993.

Symer, D.E., Paznekas, W.A., and Shin, H.S.: A requirement for membrane-associated phospholipase A2 in platelet cytotoxicity activated by receptors for IgG and complement. J. Exp. Med. 177: 937-947, 1993.

Symer, D.E., Dintzis, R.Z., Diamond, D.J., and Dintzis, H.M.: Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays. J. Exp. Med. 176: 1421-1430, 1992.

Diamond, D.J., Szalay, P., Symer, D., Hao, P., Shin, H.S., Dintzis, R.Z., Dintzis, H.M., Reinherz, E. and Siliciano, R.F.: Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives. J. Exp. Med. 174: 229-241, 1991.

Nishijima, J. Wright, T.M., Hoffman, R.D., Liao, F., Symer, D.E. and Shin, H.S.: Lysophosphatidylcholine metabolism to 1,2-diacylglycerol in lymphoblasts: involvement of a phosphatidylcholine-hydrolyzing phospholipase C. Biochemistry 28: 2902-2909, 1989.

Slezak, S., Symer, D.E. and Shin, H.S.: Platelet-mediated cytotoxicity. Role of antibody and C3, and localization of the cytotoxic system in membranes. J. Exp. Med. 166: 489-505, 1987.

Repasky, E.A., Symer, D.E. and Bankert, R.B.: Spectrin immunofluorescence distinguishes a population of naturally capped lymphocytes in situ. J. Cell Biol. 99: 350-355, 1984.