Ohio State Navbar

Sign In

Amanda Toland, PhD

Associate Professor

Department of Cancer Biology and Genetics
Human Cancer Genetics Program

For More Information:

Please visit Human Cancer GeneticsAssociate Professor~

Contact Information:

Office:

998 Biomedical Research Tower
460 W 12th Avenue
Columbus, OH 43210
Ph. (614) 247-8185

Fax: 614-688-8675
E-Mail: amanda.toland@osumc.edu 

 Laboratory:

950 Biomedical Research Tower
460
W. 12th Ave, Columbus, OH 43210
Phone: 614-247-7309


 

Research Interest:

Identification of cancer susceptibility genes

Research Summary:


Selected publications (of >125):
Wei L, Allain DC, Bernhardt MN, Gillespie JL, Peters SB, Iwenofu OH, Nelson HH, Arron ST, Toland AE. Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs. Br J Dermatol April 29, 2017 [Epub ahead of print]. PMID: 28456133

 

Yilmaz AS, Ozer HG, Gillespie JL, Allain DC, Bernhardt MN, Furlan KC, Castro LT, Peters SB, Nagarajan P, Kang SY, Iwenofu OH, Olencki T, Teknos TN, Toland AE. Differential mutation frequencies in metastastic cutaneous squamous cell carcinomas versus primary tumors. Cancer 123:1184-1193, 2017.

Moghadasi S, Meeks HD, Vreeswijk MP, Janssen LA, Borg Å, Ehrencrona H, Paulsson-Karlsson Y, Wappenschmidt B, Engel C, Gehrig A, Arnold N, Hansen TVO, Thomassen M, Jensen UB, Kruse TA, Ejlertsen B, Gerdes AM, Pedersen IS, Caputo SM, Couch F, Hallberg EJ, van den Ouweland AM, Collée MJ, Teugels E, Adank MA, van der Luijt RB, Mensenkamp AR, Oosterwijk JC, Blok MJ, Janin N, Claes KB, Tucker K, Viassolo V, Toland AE, Eccles DE, Devilee P, Van Asperen CJ, Spurdle AB, Goldgar DE, García EG.  The BRCA1 c.5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium. J Med Genet May 10, 2017 [Epub ahead of print]. PMID:28490613

Siekmann T, Gerber MM, Toland AE. Variants in an HDAC9 intronic enhancer plasmid impact Twist1 expression in vitro. Mamm Genome 27(3):99-110, 2016.

Gillespie J, Skeeles LE, Allain DC, Kent MN, Peters SB, Nagarajan P, Yu L, Teknos TN, Olencki T, Toland AE. MicroRNA expression profiling in metastatic cutaneous squamous cell carcinoma.  J Eur Acad Dermatol Venereol, 30:1043-1045, 2016

Lee C, Banerjee T, Gillespie J, Ceravolo A, Parvinsmith MR, Starita L, Fields S, Toland AE, Parvin JD. Functional analysis of BARD1 missense variants in homology directed repair of DNA double strand breaks. Hum Mutat. 36(12): 1205-1214, 2015.

Gerber MM, Hampel H, Zhou XP, Schulz NP, Suhy A, Deveci M, Çatalyürek UV, Toland AE. Allele-specific imbalance mapping at human orthologs of mouse susceptibility to colon cancer (Scc) loci. Int J Cancer 137:2323-2331, 2015.

Fleming JL, Dworkin AM, Allain DC, Fernandez S, Wei L, Peters SB, Iwenofu OH, Ridd K, Bastian BC, Toland AE. Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma. Int J Cancer, 134(1):244-248, 2014.

Fleming JL, Gable DL, Samadzadeh-Tarighat S, Cheng L, Yu L, Gillespie JL, Toland AE. Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice.  PeerJ, 1:e68, 2013.

Skeeles LE, Fleming JL, Mahler KL, Toland AE. The impact of 3’UTR variants on differential expression of candidate cancer susceptibility genes. PLoS One 8(3):e58609, 2013.

Gerber MM, Hampel H, Schulz NP, Fernandez S, Wei L, Zhou XP, de la Chapelle A, Toland AE. Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers. PLoS One 7(5):e37672, 2012.

Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, Roy R, Bastian BC, Toland AE. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genetics, Sep 23 6(9): e100136. 2010.

Sweet K, Senter L, Pilarski R, Tseng SY, Toland AE.  Classification of BRCA1 ring domain variants of uncertain significance. Br Cancer Res Treat 119(3):737-743, 2010.

Spearman AD, Sweet K, Zhou X-P, McLennan J, Couch FJ, Toland AE. Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol, 26: 5393-5400, 2008.

Ewart-Toland, A, Dai, Q, Gao, Y-T, Nagase, H, Dunlop, MG, Farrington, SM, Barnetson, RA, Anton-Culver, H, Peel, D, Ziogas, A, Lin, D, Miao, X, Sun, T, Ostrander, EA, Stanford, JL, Langlois, M, Chan, JM, Yuan, J, Harris, C, Bowman, E, Clayman, GL, Lippman, SM, Lee, JJ, Zheng, W, and Balmain, A. Aurora-A/STK15 T+91A is a low penetrance cancer susceptibility gene: a large meta-analysis of multiple cancer types. Carcinogenesis 26:1368-1373, 2005.

Ewart-Toland A, Briassouli P, de Koning JP, Mao J-H, Yuan J, Chan F., MacCarthy-Morrogh L, Ponder BAJ, Nagase H, Burns J, Ball S, Almeida M, Linardopoulos S, Balmain A.  Identification of Stk6/STK15 as a candidate modifier of cancer risk in mouse and man. Nat. Genet. 34: 403-412, 2003.

Selected Publications:

For current publications please visit The National Center for Biotechnology Information's PubMed website at Toland A PubMed.org or Ewart-Toland PubMed.org

Link to full publication list

Gerber MM, Hampel H, Schulz NP, Fernandez S, Wei L, Zhou XP, de la Chapelle A, Toland AE. Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers. PLoS One 7(5):e37672, 2012.

Bolton KL, Chenevix-Trench G, Goh C, Sadetzki S, Ramus SJ, Karlan BY, Lambrechts D, Despierre E, Barrowdale D, McGuffog L, Healey S, Easton DF, Sinilnikova O, Benítez J, García MJ, Neuhausen S, Gail MH, Hartge P, Peock S, Frost D, Evans DG, Eeles R, Godwin AK, Daly MB, Kwong A, Ma ES, Lázaro C, Blanco I, Montagna M, D'Andrea E, Nicoletto MO, Johnatty SE, Kjær SK, Jensen A, Høgdall E, Goode EL, Fridley BL, Loud JT, Greene MH, Mai PL, Chetrit A, Lubin F, Hirsh-Yechezkel G, Glendon G, Andrulis IL, Toland AE, Senter L, Gore ME, Gourley C, Michie CO, Song H, Tyrer J, Whittemore AS, McGuire V, Sieh W, Kristoffersson U, Olsson H, Borg Å, Levine DA, Steele L, Beattie MS, Chan S, Nussbaum RL, Moysich KB, Gross J, Cass I, Walsh C, Li AJ, Leuchter R, Gordon O, Garcia-Closas M, Gayther SA, Chanock SJ, Antoniou AC, Pharoah PD; EMBRACE; kConFab Investigators; Cancer Genome Atlas Research Network. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 307(4):382-390, 2012.

Efird JT, Toland AE, Lea CS, Phillips CJ. The combined influence of oral contraceptives and human papillomavirus on cutaneous squamous cell carcinoma. Clin Med Insights Oncol. 27(5):55075, 2011.

Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Morrison J,  Kartsonaki C, Lesnick T, Ghoussaini M, Barrowdale D, Peock S, Sinilnikova OM, Stoppa-Lyonnet D, Hogervorst FBL, Devilee P,  Lubinski J, Jakubowska A, Spurdle A, Healey S, John EM, Hopper JL, Buys SS, Daly MB, Southey S, Terry M-B,  Schmutzler RK, Domchek SM, Nathanson KL, Greene M, Friedman E, Andrulis I, Offit K, Borg A, Harbst K, Gerdes A-M, Thomassen M, Peterlongo P, Radice P, Caldes T, Singer CF, Greene MH, Guidugli L, Lindor NM,  Hansen TVO, Lindblom A, Rantala J, Guillermo IB, Lazaro C, Garber J, Ramus S, Gayther S, Phelan C, Narod S, Szabo CI, Osorio A, Caligo MA, Beattie M, Hamann U, Godwin AK, Montagna M, Pasini B, Neuhausen SL, Karlan BY, Tung N, Nevanlinna H, Toland AE, Weitzel J, Olopade F, Rubinstein W, Martin NG,  Montgomery GW,  Chang-Claude J, Brauch H, Severi G , Cox A, Miron P, Eccles D,  Eckel-Passow J,  Vachon C, Dunning A, Pharoah PPD, Pankratz VS, Hakonarson H, Chenevix-Trench G, Easton DF, Couch FJ. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 42(10):885-92, 2010.

Ransburgh DJR, Chiba N, Ishioka C, Toland AE, Parvin JD. Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination. Cancer Res 70(3):998-995, 2010

Sweet K, Senter L, Pilarski R, Tseng SY, Toland AE.  Classification of BRCA1 ring domain variants of uncertain significance. Br Cancer Res Treat 119(3):737-743, 2010

Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, Roy R, Bastian BC, Toland AE. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genet 6(9):e1001136, 2010.

Dworkin AM, Spearman AD, Tseng, SY, Sweet K, Toland AE.  BRCA promoter methylation is not a frequent “second hit” in tumors from BRCA carriers. Fam Cancer 8(4):339-346, 2009.

Dworkin AM, Tseng SY, Allain DC, Iwenofu OH, Peters SB, Toland AE. Merkel cell polyomavirus in cutaneous squamous cell carcinoma of immunocompetent individuals. J Invest Dermatol 129(12):2868-2874, 2009

Dworkin AM, Tober KL, Duncan FJ, Yu L, VanBuskirk AM, Oberyszyn TM, Toland AE.  Chromosomal aberrations in UVB-induced tumors of immunosuppressed mice. Genes Chromosome Cancer 48(6):490-501, 2009. PMC2739622

Fleming JL, Huang THM, Toland, AE.  The role of parental and grandparental epigenetic alterations in familial cancer risk. Cancer Res. 68(22):9116-9121, 2008.

Spearman AD, Sweet K, Zhou X-P, McLennan J, Couch FJ, Toland AE. Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol, 26: 5393-5400, 2008.

Toland AE, Rozek LS, Presswala S, Rennert G, Gruber SB. PTPRJ haplotypes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 17(10): 2782-2785, 2008.

Mahler KL, Fleming JL, Dworkin AM, Gladman N, Cho H-Y, Mao J-H, Balmain A, Toland AE. Sequence divergence of Mus Spretus and Mus Musculus across a skin cancer susceptibility locus.  BMC Genomics, 9(1):626, 2008.

Ewart-Toland, A, Dai, Q, Gao, Y-T, Nagase, H, Dunlop, MG, Farrington, SM, Barnetson, RA, Anton-Culver, H, Peel, D, Ziogas, A, Lin, D, Miao, X, Sun, T, Ostrander, EA, Stanford, JL, Langlois, M, Chan, JM, Yuan, J, Harris, CC, Bowman, ED, Clayman, GL, Lippman, SM, Lee, JJ, and Balmain, A. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis, 26: 1368-1373, 2005.
Ewart-Toland, A, Briassouli, P, de Koning, JP, Mao, J-H, Yuan, J, Chan, F., MacCarthy-Morrogh, L, Ponder, BAJ, Nagase, H, Burn, J, Ball, S, Almeida, M, Linardopoulos, S, and Balmain A. Identification of Stk6/STK15 as a candidate modifier of cancer risk in mouse and man. Nat. Genet. 34:403-412, 2003

Ewart, AK, Morris, CM, Atkinson, DA, Jin, W. Sternes, K., Spallone, P, Stock, D.A., Leppert, M, and Keating, MT.  Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome.  Nat. Genet.  5: 11-16, 1993.