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Vecchione, Andrea

Primary Appointment

Assistant Professor
Department of Cancer Biology and Genetics
Human Cancer Genetics Program 

Contact Information:

1086 Biomedical Research Tower
460 W 12th Ave
Columbus, OH 43210

E-mail : andrea.vecchione@osumc.edu, vecchione.6@osu.edu

Research Interest:

Molecular genetic and Biology of solid neoplasm.

Research Summary:

As a pathologist and molecular biologist I strongly believe that the best fight against cancer is waged at the molecular level. At every stage of my research career I have been motivated by the desire to understand the molecular and biological basis of cancer and to use the acquired knowledge to combat this deadly disease. I feel that the translation of basic science into therapeutic applications requires three equally important steps. First, we need to discover the genes, which have the potential to participate in the development and progression of human cancers. Second, we must characterize the function of these genes and the roles they play in the evolution of disease. Finally, it is critical that we translate this information into practical clinical therapies in a timely manner in order to prevent and treat cancer. I was a vital part of the research team that discovered a novel tumor suppressor gene FEZ1/LZTS1, and I have since worked to elucidate its role in the progression of solid malignancies. More recently I developed a mouse model of this gene that will be an important tool to study cancer etiology and resistance to anticancer therapy.

Selected Publications:

R. Baffa, L. G. Gommella, A. Vecchione, P. Bassi, J. Sedor, C. M. Calviello, M. Gardiman, C. Minimo, S. E. Strup, P. A. McCue, A. Kovatich, F. Pagano, K. Hubner, and C. M. Croce. Loss of FHIT expression in Transitional Cell Carcinoma of the Urinary Bladder. Am J Path 156: 419-424, 2000.

D. French, C. Cermele, A. Vecchione, M. Cenci, and A. Vecchione. HPV infection and Microsatellite Instability in squamous lesions of the uterin cervix. Anticancer Res. 20(5B):3417-3421, 2000.

E. Giarnieri, F. Consorti, A. Lorenzotti, L. Luzzato, G. Soda, A. Vecchione, and Giuseppe Midiri. Altered expression of hMSH2 in sporadic colorectal cancer, surrounding and distant colonic mucosa. Anticancer Res. 20(5C):3829-3831, 2000.

H. Ishii, K.R. Dumond, A. Vecchione1, F. Trapasso, K. Mimori, H. Alder, M. Mori, G. Sozzi, R. Baffa, and C. M Croce. Effect of Adenoviral Trasduction FHIT into Esophageal Cancer Cells. Cancer Res. 61:1578-1584, 2001. Note1:H.I, K.D, and A.V. contribuited equally to this work. IF 8.302

K. R. Dumon, H. Ishii, L. Y. Y. Fong, N. Zanesi, V. Fidanza, R. Mancini, A. Vecchione, R. Baffa, F. Trapasso, M. J. During, K. Huebner, C. M. Croce. Fhit gene Therapy prevents tumor Development in Fhit-deficient Mice. Proc Natl Acad Sci U S A. 98(6): 3346-3351, 2001.

A. Zullo, A. Romiti, V. Rinaldi.,  A. Vecchione, C. Hassan, S. Winn, S. Tomao, A. F. Attili.Gastric epithelial cell proliferation in patients with liver cirrhosis. Dig Dis Sci. 46(3):550-554, 2001.

A. Vecchione, N. Zanesi, G. Trombetta, D. French, P. Visca, T. Pisani, C. Botti, A. Vecchione, C. M. Croce, and R. Mancini. Correlation between Cervical dysplasia, ploidy and HPV status correlate with loss of Fhit expression. Clinical Cancer Res. 7:1306-1312, 2001.

A. Vecchione, H. Ishii, S. Yih-Horng , F. Trapasso, M. Rugge, J.F. Tamburrino, Y. Murakamo, H. Alder, C. M. Croce, and R. Baffa. Fez1/Lzts1 alterations in Gastric Carcinoma. Clinical Cancer Res. 7: 1546-1522, 2001.

G. Baldassarre, M. Fedele, S. Battista, A. Vecchione, A. J. P. Klein-Szanto. M. Santoro, N. Azimi, T. A. Waldman, C. M. Croce, and A. Fusco. Onset of Natural Killer Cell Lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A. 98(14): 7970-7975, 2001.

K. R Dumon, H. Ishii, A. Vecchione, F. Trapasso, G. Baldassarre, F. Chakrani, T. Druck, E. F Rosato, N. N. Williams, R. Baffa, M. J. During, K. Huebner, C. M Croce. FHIT expression delays tumor development and induces apoptosis in human pancreatic cancer. Cancer Res. 61(12):4827-4836, 2001.

H. Ishii, A. Vecchione, Y. Murakumo, G. Baldassarre, S. Numata, F. Trapasso, , R. Baffa, C.M. Croce. FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. Proc Natl Acad Sci U S A. 98(18): 10374-1039, 2001.

H. Ishii, K. R. Dumon, A. Vecchione, L. Y.Y Fong, R. Baffa, K. Huebner, and C. M. Croce. Potential cancer therapy with the Fragile Histidine Triad Gene. JAMA 286: 2441-2449, 2001.

A. Vecchione, H. Ishii, G. Baldassarre, P. Bassi, F. Trapasso, H. Alder, F. Pagano, L.G. Gomella, C.M. Croce and R. Baffa. FEZ1/Lzts1 is down regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma (TCC) cells. Am J Path 160: 1345-1352, 2002.

Fong LYY, H. Ishii, Nguyen VT, A. Vecchione, Farber JL, C.M. Croce, and K. Huebner. p53 deficiency accelerates  induction and progression of esophageal and forestomach tumors in zinc-deficient mice.  Cancer Res. 63: 186-195, 2003.

F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamury, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce, and C. Brenner. Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by susbstrate-binding. Proc Natl Acad Sci U S A. 100(14): 1592-1597, 2003.

C. Sevignani, G.A. Calin, R. Cesari, M. Sarti, H. Ishii, S. Yendamuri, A. Vecchione, F. Trapasso, C.M. Croce. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.  Cancer Res. 63: 1183 -1187, 2003.

A. Vecchione, A. Marchese, P. Henry, D. Rotin, and A. Morrione. Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the IGF-I Receptor. Mol. Cell Biol. 23: 3363-3372, 2003.

H. Ishii, N. Zanesi, A. Vecchione, F. Trapasso, S. Yendamuri, M. Sarti, R. Baffa, M.J. During, K. Huebner, L.Y.Y. Fong, and C.M. Croce. Prevention and regression of upper gastric cancer in mice by FHIT gene therapy. FASEB J. 17:1768-70, 2003. Epub 2003 Jul 03.

H. Ishii, A. Vecchione, Y. Furukawa, K. Sutheesophon, SY Han, T. Druck, T. Kuroki, F. Trapasso, M. Nishimura, Y. Saito, K. Ozawa, CM Croce, K Huebner, Y Furukawa. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res., 1: 940-947, 2003.

H. Ishii, A. Vecchione, L.Y.Y. Fong, N Zanesi, F. Trapasso, Y Furukawa, R. Baffa, K Huebner, CM Croce. Cancer prevention and therapy in a preclinical mouse model: Impact of FHIT viruses. Current Gene Therapy, 4. Curr Gene Ther. 4: 53-63, 2004.

H. Ishii, K. Mimori, A. Vecchione, K. Sutheesophon, T. Fujiwara, M. Mori, and Y. Furukawa. Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX. Biochemical and Biophysical Research Communications 316: 1088–1093, 2004.

C. Morelli, C. Garofalo, D. Sisci, S. del Rincon, S. Cascio, X. Tu, A. Vecchione, E. R. Sauter, W. H. Miller Jr, and E. Surmacz. Nuclear Insulin Receptor Substrate 1 Interacts with Estrogen Receptor-a at ERE Promoters. Oncogene 23: 7517-7522, 2004.

H. Ishii, A. Vecchione, Y. Furukawa, C. M. Croce, K. Huebner and L. Y.Y. Fong. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Oncogene 21: 8040-8048, 2004.

F. Trapasso, S. Yendamuri, K.R. Dumon, R. Iuliano, R. Cesari, B. Feig, L. Infante, H. Ishii, A. Vecchione, M.J. During, C.M. Croce, and A. Fusco. Restoration of receptor-type protein tyrosine phosphatase h function inhibts human pancreatic carcinoma cell growth in vitro and in vivo. Carcinogenesis 25: 2107-2114, 2004.

A. Vecchione, H. Ishii, E. Giarnieri, G. Baldassarre, T. Prayer Galetti, F. Pagano, L.G. Gomella, C. M. Croce and R. Baffa. Clinical-pathological   significance of Fez1 protein expression in Bellini duct (collecting duct) carcinoma of the kidney. BMC Urol. 4:1-11, 2004.

A. Vecchione, C. Sevignani, E. Giarnieri, N.  Zanesi, H. Ishii, R. Cesari, L. G. Gomella, C. M. Croce, and R. Baffa. Inactivation of the FHIT gene favors bladder cancer development. Clinical Cancer Res 15: 7607-7612, 2004.

G. Baldassarre, B. Belletti, M. S. Nicoloso, M. Schiappacassi, A. Vecchione, P. Spessotto, A. Morrione and A. Colombatti. p27Kip1-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 7:51-63, 2005.

D. Nonaka, A. Fabbri, L. Roz, L. Mariani, A. Vecchione, G. W. Moore, L. Tavecchio, C. M. Croce and G. Sozzi. Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer. Cancer Res. 65:1207-1212, 2005. 

 H. Ishii, K. Mimori, Y. Yoshikawa, M. Mori, Y. Furukawa, A. Vecchione. Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells. DNA and Cell Biology 24:173:179, 2005.

Ishii H, Mimori K, Inageta T, Murakumo Y, Vecchione A, Mori M, Furukawa Y. Components of DNA Damage Checkpoint Pathway Regulate UV Exposure-Dependent Alterations of Gene Expression of FHIT and WWOX at Chromosome Fragile Sites. Mol Cancer Res. 3:130-138, 2005.

H. Ishii, K. Mimori, M. Mori, A. Vecchione. Differentially expressed genes in endothelial differentiation. DNA and Cell Biology 24: 432-437, 2005.

N. Zanesi, R. Mancini, C. Sevignani, A. Vecchione, M. Valtieri, G.A. Calin, G. La Rocca, J. Gnarra. C.M. Croce, K. Huebner. Lung cancer in Fhit deficient mice: synergism with Vhl. Cancer Research Cancer Res. 65:6576-6582, 2005.