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Sadee, Wolfgang, PhD

Professor
Department of Cancer Biology and Genetics
Director, Center for Pharmacogenomics

 

Contact Information

Office:

5072 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210
Ph: (614) 292-5593
Fax: (614) 292-7232
E-Mail: sadee.1@osu.edu

 

Research Interests

General Research Interest

Pharmacogenomics of cancer, cardiovascular diseases, and CNS disorders. Link to the OSU Program in Pharmacogenomics: http://pharmacogenomics.osu.edu/.
 

Research Description

Dr. Sadee's research focuses on individual variability in gene expression, as a main cause of genetic differences in drug response and toxicity. His laboratory also uses chemogenomics approaches in drug discovery and biomarker development

Transinstitutional Work
 
The Program in Pharmacogenomics supports multiple clinical trials, initiated upon discovery of novel regulatory polymorphisms with likely clinical relevance. Clinicla trials are ongoing with collaborators at the OSU CCC, the OSU Dorothy Davis Heart and Lung Research Institute and with multiple sites extramurally.
 

Recent Publications

 
1. Barrie ES, Weinshenker D, Verma A, Pendergrass S, Lange L, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman G, Sadee W
Regulatory Polymorphisms in Human DBH Affect Peripheral Gene Expression and Sympathetic Activity.
Circ Res in press 10/17/2014
2. Seweryn M, Pietrzak M, Handelman SK, Rempala GA, Sadee W, Hartmann K: Missing heritability of common diseases and treatments outside the protein-coding exome. Hum Genet 133 1199-215 10/1/2014
3. Smith RM, Banks W, Hansen E, Sadee W, Herman GE: Family-Based Clinical Associations and Functional Characterization of the Serotonin 2A Receptor Gene (HTR2A) in Autism Spectrum Disorder. Autism Res 7 459-67 8/1/2014
4. Gadow KD, Pinsonneault JK, Perlman G, Sadee W: Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder. Res Dev Disabil 35 1658-65 7/1/2014
5. Leusink M, Onland-Moret NC, Asselbergs FW, Ding B, Kotti S, van Zuydam NR, Papp AC, Danchin N, Donnelly L, Morris AD, Chasman DI, Doevendans PA, Klungel OH, Ridker PM, van Gilst WH, Simon T, Nyberg F, Palmer CN, Sadee W, van der Harst P, de Bakker PI, de Boer A, Verstuyft C, Maitland-van der Zee AH
Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events. Clin Pharmacol Ther 95 314-20 3/1/2014
6. Toneff T, Hook V, Sadee W, Suhy A, Hartmann K, Newman L, Papp A: Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein. Biochem Biophys Res Commun 443 1270-4 1/24/2014
7. Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee W: Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity. Hum Mol Genet 23 268-78 1/1/2014
8. Di Giorgio A, Smith RM, Fazio L, D'Ambrosio E, Gelao B, Tomasicchio A, Selvaggi P, Taurisano P, Quarto T, Masellis R, Rampino A, Caforio G, Popolizio T, Blasi G, Sadee W, Bertolino A: DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory. PLoS One 9 e95997 1/1/2014
9. Pinsonneault JK, Sullivan D, Sadee W, Soares CN, Hampson E, Steiner M: Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study. Arch Womens Ment Health 16 499-509 12/1/2013
10. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM: Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther 94 636-9 12/1/2013
11. Sadee W: Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example.  J Pharm Sci 102 2924-9 9/1/2013
12. Sadee W: Bridging material and biological sciences: the legacy of Hans Peter Merkle. Eur J Pharm Biopharm 85 3-4 9/1/2013
13. Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CG: The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clin Pharmacol Ther 94 207-10 8/1/2013
14. Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CG:  The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.  Clin Pharmacol Ther 94 207-10 8/1/2013
15. Webb A, Papp AC, Sanford JC, Huang K, Parvin JD, Sadee W: Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.
Pharmacogenet Genomics 23 269-78 5/1/2013
16. Smith RM, Papp AC, Webb A, Ruble CL, Munsie LM, Nisenbaum LK, Kleinman JE, Lipska BK, Sadee W
Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.
Biol Psychiatry 73 546-54 3/15/2013
17. Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA: Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents. Transl Res 161 156-64 3/1/2013
18. Azad AK, Curtis A, Papp A, Webb A, Knoell D, Sadee W, Schlesinger LS: Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene.
Genes Immun 14 99-106 3/1/2013
19. Sanford JC, Guo Y, Sadee W, Wang D: Regulatory polymorphisms in CYP2C19 affecting hepatic expression. Drug Metabol Drug Interact 28 23-30 1/1/2013
20. Kitzmiller JP, Sullivan DM, Phelps MA, Wang D, Sadee W: CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control. Drug Metabol Drug Interact 28 59-63 1/1/2013
21. Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, Sadee W, Sullivan D: Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction.
Transl Psychiatry 3 e222 1/1/2013
22. Smith RM, Webb A, Papp AC, Newman LC, Handelman SK, Suhy A, Mascarenhas R, Oberdick J, Sadee W
Whole transcriptome RNA-Seq allelic expression in human brain. BMC Genomics 14 571 1/1/2013