The Center for Vascular Biology and Translation (CVRT) builds on the strengths of The Ohio State University Wexner Medical Center by creating a collaborative and synergistic environment centered on vascular biology. From the genome and epigenome to clinical outcomes, our investigator expertise touches every facet of vascular disease. In addition, the CVRT will facilitate recruitment of outstanding investigators with complementary interests to bring an even more robust research enterprise.

The CVRT offers excellent opportunities for industry partnerships, multi-investigator grants and provides a rich environment for trainees. We are driven by the mindset that every molecular mechanism identified in disease pathology could be a new therapeutic target.

Our mission is to improve human health by translating mechanistic discoveries of vascular disease into transformative therapies.

Our Research

The cells and tissues in our bodies are kept alive by a remarkable network of blood vessels that deliver oxygen and nutrients while also removing waste products. When these blood vessels become diseased, blood flow to tissues downstream of the vessels becomes inadequate or sometimes stops completely. This is immediately dire if the downstream tissue is the brain (stroke) or the heart (heart attack). Collectively, these account for almost 30% of all deaths in the US and vascular disease is clearly the most significant cause of morbidity and mortality in the developed world. Moreover, the vasculature is remarkably susceptible to disease when the individual is obese and/or diabetic. Both, obesity and diabetes, are expected to reach pandemic proportions in the coming decades. There is a clear and rapidly growing unmet medical need for effective therapeutic strategies to prevent and treat vascular diseases. Our researchers are working day and night to learn more about the molecular mechanisms of intimal hyperplasia, thrombosis, aneurism and fibrosis with the hope of using this knowledge to develop new treatments.

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