GarikipatiLabPeopleIn the Human genome, well-studied sequences are protein-coding genes, which account for only 1.5–2% of the total genome; with the advancement in sequencing technologies now, it is evident that a significant proportion of them are non-coding RNAs (ncRNAs). We evaluate the biogenesis and function of short ncRNAs micro RNA (miRNA), small nucleolar RNA (snoRNA) and Piwi-interacting RNA (piRNA), and long ncRNAs linear long-noncoding RNA (lncRNA) and circular RNA (circRNA) in cardiovascular health and disease. We employ various modern and classical technologies such as RNA sequencing, single-molecule FISH, non-coding RNA pull-down assays, exosomes isolation, AAV9 mediated non-coding RNA delivery, LNA Gapmer based non-coding RNA silencing, and mouse models (diabetic and non-diabetic) of myocardial infarction. We believe identifying and characterizing non-coding RNA that play a regulatory role in the network of interactions governing cardiovascular health and disease is a real puzzle that needs to be solved to allow better treatment and prevention of cardiovascular disease. Our long-term goal is to identify novel therapeutic targets for the treatment of myocardial infarction.

Dr.Garikipati’s lab focuses on the following research areas:

  • Role of long ncRNA (lncRNA and circular RNA) in diabetic cardiomyopathy 
  • Role of small ncRNA (miRNA, mtRNA, snoRNAs, and piRNA) in cardiovascular health and disease
  • Role of exosomal- ncRNA (lncRNA, circular RNA, miRNA, snoRNAs, and piRNA)  in cardiovascular health and disease
  • We are also investigating the space flight associated exosomal RNA changes in the astronaut's plasma (In collaboration with Dr.Goukassian at Mount Sinai, NY).

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