Importance of restorative medicine research
We take great pride in breakthroughs discovered through restorative medicine research. Inspiration starts with our patients. Designated as a Level 1 trauma center by the American College of Surgeons, Ohio State’s Medical Center is widely recognized for its expertise in the care of trauma patients, with on-site physicians in more than 40 medical specialties.
The research program at Ohio State utilizes state-of-the-art molecular technologies to understand mechanisms that impair healing of chronic wounds as well as to understand the actions of specific therapeutic intervention. It’s focused on minimally invasive techniques and closed reduction maneuvers for minimal recovery times and faster restoration of function.
Since 2004, Healogics Inc., the nation’s largest provider of advanced wound care services, and Ohio State have been working together through clinical research and education, to directly impact the wound care industry. A strong multidisciplinary team consisting of clinicians, molecular biologists, imaging specialists, biomedical engineers, statisticians and system biologists support the research program. There is a continuum from bench to bedside. As a strategic partner, Ohio State guides decisions that impact a network of over 800 wound care centers nationwide spanning the entire spectrum of patient care environments and demographics.
In the United States, skin wounds affect 6.5 million patients and place a major burden, an estimated $25 billion annually, on society. Wound infections are not only expensive complications following surgery but still after many years are a major source of bacteria that drive the nosocomial infection rates in hospitals. These infections complicate illness, cause anxiety, increase patient discomfort and can lead to death.
Using electroceuticals, the application of electric currents or fields to modulate biological function for therapeutic purposes, we have shown by applying induced electric fields that we can affect cell migration in a non-contact manner. This opens the door to controllable healing, management of which cell types move where and when, as well as enabling healing of superficial wounds.
Our researchers have even worked on a few topical solutions for wound care. Studies from the lab have indicated that fermented papaya preparation (FPP) may improve diabetic wound outcomes by specifically aiding in the timely onset and resolution of inflammation and the formation of new blood vessels. Other research shows that modified collagen gel (MCG) improves wound closure by induction of a robust transient inflammatory response followed by improved wound tissue vascularization and collagen deposition.
Some of our areas of our wound, burn and trauma research include…
- diabetic wound healing
- miRNA therapeutics, wound inflammation and angiogenesis,
- redox and oxygen biology,
- non-invasive wound imaging,
- biofilm, infection and therapeutics,
- wound genomics (microarray), proteomics and laser capture microdissection (LCM).
Avner Friedman, PhD, MS
Daniel Wozniak, PhD
Gayle Gordillo, MD, FACS
Heather Megan Powell, PhD
Jodi C. McDaniel, PhD
John F. Sheridan, PhD
Kathleen Ham, DVM, MS, DACVS
Sashwati Roy, PhD
Savita Khanna, PhD
Traci A. Wilgus, PhD
Ian L. Valerio, MD, MS, MBA, FACS
Jose Javier Otero, MD, PhD
Ronald Xu, PhD
Said A. Atway
Larry M. Jones, MD
Leah Pyter, PhD