What is tissue engineering?

Tissue engineering research at The Ohio State University encompasses many disciplines, applying the principles of engineering and life sciences to develop biological substitutes to restore or improve tissue function. Analysis of biomaterials, stem cells, growth factors, and microenvironments are creating opportunities to fabricate tissues in the laboratory from combinations of engineered extracellular scaffolds, cells, and biologically active molecules. Engineered tissue has vast implications for craniofacial reconstruction, respiratory and lung disorders, diabetes, cardiovascular disease, and creating bone and soft tissue replacements. Tissue engineering technology and techniques are used in vascular grafting, bone 3D printing, and organoid development among other medical developments.

Ohio State has a world-leading tissue engineering vascular grafts program and was first-in-human with an FDA approved, ongoing clinical trial for vascular tissue engineering. The program has developed tissue engineered vascular grafts (can grow, repair, and remodel) for use in congenital heart surgery. The tissue engineered vascular graft is the first manmade vascular graft with growth potential making it uniquely suited for use in children where somatic overgrowth is a significant barrier to progress in the field.

Our tissue engineered intestine program is making progress toward further potential use of the technology by studying growth factors in protection of the intestines from injury, stem cells in protection of the intestines from injury, and production of tissue-engineered intestine.

Our Researchers

Alok Sutradhar, PhD
Arthur J. Epstein, PhD, MS
Heather Megan Powell, PhD
Jessica O. Winter, PhD
Jianjun Guan, PhD
Peter Martin Anderson, PhD
Richard T. Hart, PhD
Samir N. Ghadiali, PhD, MS
Scott Schricker, PhD
Liang Guo, PhD
Jed Johnson, PhD
R. Lawrence Moss, MD
Do-Gyoon Kim, PhD
Gail E. Besner, MD