Wang_Bowen_460x460Bowen.Wang@osumc.edu
608-609-7933

Cardiovascular diseases are the leading cause of death in developed countries. So far there is a lack of non-invasive therapeutic strategies to effectively prevent and reverse the development of vascular lesions such as restenosis and aneurysm. Dr. Bowen Wang is dedicated to utilizing an interdisciplinary approach to not only understand their etiologies, but also develop prototypes of effective therapeutics that can lead to future application in vascular patients. 

Dr. Wang's research interest in understanding the molecular basis of phenotypic switching in vascular diseases, and translating them into novel therapeutics via bioinspired nanoplatforms.

Education

  • PhD: Cellular and Molecular Pathology, University of Wisconsin-Madison
  • Bachelor of Medicine: Peking University, Health Science Center, Beijing

Research Interests

  • Restenosis
  • Vascular injury
  • Phenotypic switching
  • Restenosis
  • Aneurysm
  • Biomimetic medicine
  • Nanomedicine

Relevant Publications

  • Wang B*, Chen G, Urabe G, Xie R, Wang Y, Shi X, Guo L-W, Gong S, Kent KC. A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters. Biomaterials 178:293-301 (2018).
  • Chen G, Shi X, Wang B, Xie R, Guo L-W, Gong S, Kent KC. Unimolecular micelle-based hybrid system for perivascular drug delivery produces long-term efficacy for neointima attenuation in rats. Biomacromolecules 18:2205-2213 (2017).
  • Pan X, Wang B*, Yuan T, Zhang M, Kent KC, Guo LW. Analysis of Combined Transcriptomes Identifies Gene Modules that Differentially Respond to Pathogenic Stimulation of Vascular Smooth Muscle and Endothelial Cells. Scientific Reports 8:395 (2018).
  • Yu Q, Wang B, Chen Z, Urabe G, Glover MS, Shi X, Guo LW, Kent KC, Li L. Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)-Enabled Intact Glycopeptide/Glycoproteome Characterization. Journal of The American Society for Mass Spectrometry 9:31751-1764 (2017).
  • Zhu Y, Takayama T, Wang B*, Kent A, Zhang M, Binder BY, Urabe G, Shi Y, DiRenzo D, Goel SA, Zhou Y, Little C, Roenneburg DA, Shi XD, Li L, Murphy WL, Kent KC, Ke J, Guo LW. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Scientific Reports 7:41916 (2017).
  • Shi XD, Guo L-W, Seedial SM, Wang B, Takayama T, Franco S, DiRenzo DM, Bo Liu, Kent KC. Local CXCR4 induction in the injured arterial wall contributes to intimal hyperplasia. Stem Cells (2016)
  • Wang B, Zhang M, Takayama T, Shi XD, Roenneburg D, Kent KC, Guo L-W. BET bromodomain blockade mitigates intimal hyperplasia in rat carotid arteries. EBioMedicine 2:1650-61 (2015)
  • Wang B, Zhang M, Takayama T, Shi XD, Roenneburg D, Kent KC, Guo L-W. BET bromodomain blockade mitigates intimal hyperplasia in rat carotid arteries. EBioMedicine 2:1650-61 (2015)
  • Guo L-W, Wang B*, Goel SA, Takayama T, Little C, Roenneburg D, Kent KC. Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries. Circulation-Cardiovascular Intervention 7(4): 594-601 (2014).
  • Shi X, Guo L-W, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B, Kent KC. TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A. Cell Death & Disease. 5:e1317 (2014).
  • Shi X, DiRenzo D, Guo L-W, Franco SR, Wang B, Seedial SM, Kent KC. TGF-β/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation. PloS one. 9:e93995 (2014).