Department of Internal Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
201 Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus, OH 43210
Phone: 614-293-5822
Fax: 614-293-9820
Brian.Keller2@osumc.edu
Research Interests
- Novel diagnostics and therapeutics to improve lung transplantation outcomes
- Lung virome and microbiome in health and disease
- Total Transplant Care Protocol: Lung Transplant Biorepository
Current Research
My research focuses on improving outcomes after lung transplantation by studying novel diagnostic and therapeutic approaches to allograft rejection. I currently lead the Lung Transplant Research Group and am PI for several clinical trials. I oversee collection of data and specimens for the lung transplant biorepository and have an interest in utilizing this unique resource to evaluate the lung virome and microbiome.
Active projects include:
- Letermovir for CMV prophylaxis in lung transplant recipients intolerant of valganciclovir
- Early acute kidney injury after lung transplant
- Use of cell-free DNA to detect allograft dysfunction
- Extracorporeal photopheresis for the treatment of bronchiolitis obliterans syndrome
- Inhaled cyclosporine for early bronchiolitis obliterans syndrome
Research Techniques
- Biobanking
- Research bronchoscopy
- Next-generation sequencing
- Bioinformatics
- REDCap
Education
Medical Degree: University of Texas Southwestern Medical School
PhD: Molecular microbiology, University of Texas Southwestern Graduate School of Biomedical Sciences
Residency: Internal Medicine Residency, Washington University School of Medicine
Fellowship: Pulmonary and Critical Care Medicine Fellowship, Washington University School of Medicine
Fellowship: Postdoctoral Research Scholar, Metagenomics, Washington University School of Medicine
Book Chapters
- Keller BC, Brody SL. “Viral pulmonary infections.” In: The Washington Manual Pulmonary Medicine Subspecialty Consult. Second edition. Edited by Shifren A, Byers DE, Witt CA. Philadelphia: Wolters Kluwer, 2017
Honors and News
- Faculty Leadership Institute, 2019-2020
- NIH Loan Repayment Program Renewal Grantee, 2016
- American Thoracic Society Abstract Scholarship, Assembly on Allergy, Immunology and Inflammation, 2016
- Fellows Track Symposium, American Thoracic Society International Conference, 2015
- NIH Loan Repayment Program Grantee, 2014