Keller_Brian_720x720Department of Internal Medicine
Division of Pulmonary, Critical Care and Sleep Medicine

201 Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus, OH 43210
Phone: 614-293-5822
Fax: 614-293-9820
Brian.Keller2@osumc.edu

Research Interests

  • Novel diagnostics and therapeutics to improve lung transplantation outcomes
  • Lung virome and microbiome in health and disease
  • Total Transplant Care Protocol: Lung Transplant Biorepository

Current Research

My research focuses on improving outcomes after lung transplantation by studying novel diagnostic and therapeutic approaches to allograft rejection. I currently lead the Lung Transplant Research Group and am PI for several clinical trials. I oversee collection of data and specimens for the lung transplant biorepository and have an interest in utilizing this unique resource to evaluate the lung virome and microbiome.

Active projects include:

  • Letermovir for CMV prophylaxis in lung transplant recipients intolerant of valganciclovir
  • Early acute kidney injury after lung transplant
  • Use of cell-free DNA to detect allograft dysfunction
  • Extracorporeal photopheresis for the treatment of bronchiolitis obliterans syndrome
  • Inhaled cyclosporine for early bronchiolitis obliterans syndrome

Research Techniques

  • Biobanking
  • Research bronchoscopy
  • Next-generation sequencing
  • Bioinformatics
  • REDCap

PubMed articles  ResearchGate articles

Education

Medical Degree: University of Texas Southwestern Medical School
PhD: Molecular microbiology, University of Texas Southwestern Graduate School of Biomedical Sciences
Residency: Internal Medicine Residency, Washington University School of Medicine
Fellowship: Pulmonary and Critical Care Medicine Fellowship, Washington University School of Medicine
Fellowship: Postdoctoral Research Scholar, Metagenomics, Washington University School of Medicine

Book Chapters

  • Keller BC, Brody SL. “Viral pulmonary infections.” In: The Washington Manual Pulmonary Medicine Subspecialty Consult. Second edition. Edited by Shifren A, Byers DE, Witt CA. Philadelphia: Wolters Kluwer, 2017

Honors and News

  • Faculty Leadership Institute, 2019-2020 
  • NIH Loan Repayment Program Renewal Grantee, 2016
  • American Thoracic Society Abstract Scholarship, Assembly on Allergy, Immunology and Inflammation, 2016
  • Fellows Track Symposium, American Thoracic Society International Conference, 2015
  • NIH Loan Repayment Program Grantee, 2014

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