The Accornero laboratory studies the mechanisms underlying heart and skeletal muscle diseases, with a primary focus on the role of RNA-binding proteins and RNA modifications in regulating the expression of pathologic genes during stress challenges.
One line of work is focused at understanding the function of BEX family proteins. We found that BEX1 is part of a ribonucleoprotein complex which inhibition is protective for the heart. We are now examining the molecular pathways controlled by BEX1, as well as the contribution of novel BEX proteins to cardiac and skeletal muscle pathologies.
A second line of work focuses at understanding the contribution of messenger RNA (mRNA) methylation to muscle diseases. By generating mouse models with affected levels of mRNA methylation we are exploring this uncharacterized phenomenon in cardiomyopathy and muscular dystrophy.
Finally, a third line of work aims at discovering novel mechanistic insights into the regulation of tissue fibrosis and inflammation.
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Education and Training
PhD, University of Turin, Italy
Post Doctoral, Cincinnati Children’s Hospital Medical Center