Ohio State Navbar

Sign In

Caroline Whitacre, PhD


Emeritus Professor, Microbial Infection and Immunity 

Contact information:​

Research Interests

Immune tolerance, CNS autoimmune disease, multiple sclerosis, animal models for the study of multiple sclerosis, gender differences in autoimmune disease, neuroendocrine-immune interactions, immune effects in spinal cord injury.

Dr. Whitacre's research uses cellular and molecular approaches to devise therapeutic regimens for multiple sclerosis focusing on the animal model, experimental autoimmune encephalomyelitis (EAE). The primary focus of research is to understand the mechanisms underlying gender differences in autoimmune diseases, specifically differences in the immune response to explain why women tend to get autoimmune diseases more often than men, yet men often exhibit a more rapidly progressive course of disease.  The lab also studies the effect of pregnancy on disease progression in MS.  A recent area of investigation is the role of microRNA in the pathogenesis and treatment of MS and EAE.