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Dana M. McTigue, PhD

Professor and Vice Chair
Department of Neuroscience

Degree: Ohio State University
Postdoctoral Training: Ohio State University

Phone: (614) 292-5523
Lab: (614) 688-5425
Fax: (614) 688-8742
Email: dana.mctigue@osumc.edu

Spinal Cord Injury Center


NLM PubMed publications list for Dana M. McTigue (past 10 years)

Google Scholar Profile

Research Area

Spinal cord injury and recovery of function, gliogenesis, adult progenitor cell function, demyelination and remyelination of the CNS.

Potential Projects

Use transgenic reporter mice to track the fate of adult progenitor cells after spinal cord injury, inflammatory lesions or demyelination

Test new potential therapies to improve cell survival and cell replacement after spinal cord injury

Use in vitro studies to examine interactions between macrophages and progenitor cells

Use in vivo microinjection of macrophage-derived mediators to determine their effects on adult glial cells

Examine the effects of spinal cord injury on peripheral organ function

Current Research Interests

Our laboratory, which is part of the newly developed Center for Brain and Spinal Cord Repair, focuses on the role of adult progenitor cells after CNS injury or disease. These cells have been shown to form new oligodendrocytes in vivo after demyelination, and to form oligodendrocytes, astrocytes and neurons in vitro. In a recent study, we determined that these cells spontaneously form a large number of new oligodendrocytes around the circumference of spinal contusion lesions. In ongoing studies we are examining: 1) What molecules present after spinal cord injury promote this rapid and pronounced gliogenesis? 2) What effect does inflammation have on the function of the progenitors and adult oligodendrocytes? 3) What type of intercellular communications are involved in gliogenesis after CNS injury, including interactions between progenitors, astrocytes, oligodendrocytes, microglia and macrophages?

The long-term goal of these studies is to determine how the formation of new cells in the adult CNS is regulated and whether this process can be manipulated to promote greater anatomical and functional recovery from spinal cord injury and other CNS disorders.


Our laboratory uses a variety of techniques to study changes after spinal cord injury. Students will have the opportunity to learn surgical techniques, behavioral analysis of spinal injured animals, intraspinal microinjection, cell culture, laser capture microdissection, real-time PCR, Western blots, light and confocal microscopy, image analysis of CNS tissue, immunohistochemistry.

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