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Coupling of Small Leucine-Rich Proteoglycans to Hypoxic Survival of a Progenitor Cell-Like Subpopulation in Rhesus Macaque Intervertebral Disc 

 

Coupling of Small Leucine-Rich Proteoglycans to Hypoxic Survival of a Progenitor Cell-Like Subpopulation in Rhesus Macaque Intervertebral Disc
Intervertebral disc (IVD) tissue-specific progenitor cells and their niche components are not clear, although degenerated IVD-derived cells possess in vitro characteristics of mesenchymal stromal cells. The authors identified the tissue-specific intervertebral disc progenitor cells (DPCs) from healthy Rhesus monkey and report the niche components modulated the survival of DPCs under hypoxia. DPCs possess clonogenicity, multipotency and retain differentiation potential after extended expansion in vitro and in vivo.

 

Posted on 20-Jun-13 by Suri, Prerna
Tags: Science and Industry News
 
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