Additive Manufacturing of Polycaprolactone
(PCL) Scaffolds and Endovascular Stents
Thursday, May 17
1:30 p.m. – 2:30 p.m.
E525 Scott Laboratory
Dr. Joaquim Ciurana
Professor, University of Girona
Dr. Joaquim de Ciurana holds a Ph.D. in Industrial Engineering from UPC (1997). He has completed several postdoctoral stays at Rutgers (The State University of NJ), Cranfield University (UK), and Université du Québec à Trois-Rivières (Canada). At the University of Girona he has been a full professor of Manufacturing Process Engineering since 2009. His research in Product Engineering, Process and Production at the University of Girona has resulted in more than 100 journal articles about design methodologies, planning of manufacturing processes, characterization of machining and additive manufacturing processes, and design and prototyping of medical devices. He has also participated in writing 12 book chapters and has participated in 80 international and national conferences. In recent years he has led several research projects in the biomedical field, such as in designing new medical devices, manufacturing prototypes for the biomedical sector, or improvement systems for cell culture in the field of tissue engineering. He also devotes special attention to the collaboration between the industrial sector and research, as noted by a November 2011 ASCAMM Technology Center award for scientific collaboration with corporate partners.
He has promoted numerous collaboration
Additive Manufacturing (AM) technologies allow rapid and efficient
production of custom-designed parts. However, optimization of the
design, printing material characteristics, and fabrication
parameters, are usually required to insure desirable manufacturing
results. We present our AM experience at the Research group of
product, process and production engineering (GREP) – University
of Girona (Spain) with biomedical devices such as stents or tissue
engineering scaffolds. Our work to date focuses on the
optimization and parameter selection for an open-source 3D
extrusion AM device to manufacture Poly(Ɛ-CaproLactone) (PCL)
scaffolds or PCL endovascular stents. PCL is biocompatible and
nontoxic polymer, which has been used to fabricate scaffolds,
including solid structures suitable for 3D cancer cell culture.
Scaffold cell culture has been shown to enhance the Cancer Stem
Cells (CSCs) population, related to tumour chemoresistance and
recurrence after chemotherapy. Bioabsordable stents (BRS) for
endovascular use offer the potential to improve long-term patency
by providing support just long enough for the artery to heal itself.
Currently, the stent industry primarily uses laser micro cutting
fabrication for metallic, non-resorbing stents. Nevertheless,
polymer BRS systems prepared by Additive Manufacturing
techniques could be a better solution.