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Alicia L. Bertone, DVM, PhD

Alicia L. Bertone, DVM, PhD
The Trueman Chair in Equine Clinical Medicine and Surgery
The Ohio State University
Phone: (614) 292-7449
The CORL’s research has focused on the translational science in the area of gene therapy, cell therapy, and molecular engineering. The laboratory has demonstrated that the direct and cell-based gene therapy can promote improved healing of bone and cartilage tissue with rodent and equine models by using sophisticated imaging and gene expression analysis. These gene therapy strategies have already entered a clinical trial for complicated orthopedic disorders in various veterinary patients such as dogs, horses, and llamas. In addition, the laboratory has extensive studied the RNA-silencing technology to modurate cytokine activities for the treatment of arthritis with rodent models. Moreover, CORL has performed a number of equine exercise physiology projects to study the pharmacokinetics of several medications used for the treatments of musculoskeletal diseases. Furthermore, the laboratory has investigated the efficacy and safety of platelet-rich plasma therapy for the treatments of joint and ligament disorders as it’s already moved forward to clinical trials of equine patients with osteoarthrits and ligament injuries. All of these research works have shown extensive promising results, and some of therapeutic methods have already been applied for clinical cases with orthopedic conditions to make substantial contributions on health and welfare of veterinary patients and clients.
Team Members
Akikazu Ishihara, Research associate
Emma Adam, PhD graduate student
Eric skinner, PhD graduate student
Hayam Hussein, PhD graduate student
John Pigott, MSc graduate student
Chrissie Pariseau, MSc graduate student
Research Interests
Dr Bertone has an interest in the molecular and stem cell therapy for various orthopedic disorders, pharmacokinetics of medications for the treatments of musculoskeletal diseases, nuclear imaging to study equine arthritis, and autologous blood products for equine bone and joint disorders. Dr Bertone has also designed the first commercial-grade equine microarray (equine GeneChip®). Dr Bertone is the Director of the Comparative Orthopedic Research Laboratories (CORL) in the College of Veterinary Medicine at The Ohio State University (OSU). Dr Bertone serves in the Trueman Endowed Chair at OSU, as well as the Director of Basic Science and Industry Contracts in Sports, Health and Performance Institute at OSU.
Selected Publications
Bertone AL, Santangelo KS. Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis. Osteoarthritis Cartilage. 2011; 19: 1449-57.

Bertone AL, Menendez MI. Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model. Osteoarthritis Cartilage. 2011; 19: 1066-75.
Bertone AL, Santangelo KS. Temporal expression and tissue distribution of interleukin-1β in two strains of guinea pigs with varying propensity for spontaneous knee osteoarthritis. Osteoarthritis Cartilage. 2011; 19: 439-48.

Bertone AL, Ishihara A. Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model. Gene Ther. 2010; 17: 733-44.

Bertone AL, Santangelo KS. Detectable reporter gene expression following transduction of adenovirus and adeno-associated virus serotype 2 vectors within full-thickness osteoarthritic and unaffected canine cartilage in vitro and unaffected guinea pig cartilage in vivo. J Orthop Res. 2010; 28: 149-55.

Bertone AL, Waselau M. Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses. J Am Vet Med Assoc. 2008; 232: 1515-20.

Bertone AL, Ishihara A. Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models. J Orthop Res. 2008; 26: 764-71.

Bertone AL, Zachos TA. Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model. Mol Ther. 2007; 15:1543-50.

Bertone AL, Zachos TA. Gene-mediated osteogenic differentiation of stem cells by bone morphogenetic proteins-2 or -6. J Orthop Res. 2006; 24: 1279-91.

Bertone AL, Gu W. Generation and performance of an equine-specific large-scale gene expression microarray. Am J Vet Res. 2004; 65: 1664-73.