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Jon R. Parquette, PhD

Jon R. Parquette, PhD
Professor of Chemistry
Phone: (614) 292-5886
Email: parquett@chemistry.ohio-state.edu

The self-assembly of small molecules into one-dimensional nanostructures offers many potential opportunities for the development of new biomedical materials with functions ranging from targeted drug delivery to tissue engineering. In order to realize the potential for nanoscale self-assembly to contribute to these applications, it is important to control the size, shape, and internal/external surface structure of the nanostructures in a predictable and versatile manner. Most applications require the assembly or co-integration of functional co-factors that may include specific drugs or imaging agents for biomedical applications.  Thus, the self-assembly process must not only be controllable with regard to nanostructure, it must be capable of integrating these functional components.  We have developed several versatile strategies that permit functional chromophores to be assembled into one-dimensional nanostructures, such as nanotubes, based on -sheet aggregation and/or amphiphilic association in water (Fig. 1). A key element of this strategy takes advantage of the co-factor to drive self-assembly via hydrophobic  stacking interactions. The  interactions are further attenuated by designed intermolecular electrostatic repulsions, which are generally created by protonated lysine residues.  Thus, by adjusting the balance of attractive and repulsive forces, the self-assembly process can be tailored to provide discrete, soluble nanostructures with controllable properties and functionality.
Team Members
7 graduate students 
Research Interests
Organic Self-Assembly
Drug delivery
Selected Publications
Tu, S. Y.; Kim, S. H.; Joseph, J.; Modarelli, D. A.; Parquette, J. R.* Self-Assembly of a Donor-Acceptor Nanotube. A Strategy To Create Bicontinuous Arrays. J. Am. Chem. Soc. 2011, 133, 19125. 
Shao, H.; Gao, M.; Kim, S. H.; Jaroniec, C. P.; Parquette, J. R.* Aqueous Self-Assembly of L-Lysine-Based Amphiphiles into 1D n-Type Nanotubes. Chem.-Eur. J. 2011, 17, 12882.
Shao, H.; Seifert, J.; Romano, N. C.; Gao, M.; Helmus, J. J.; Jaroniec, C. P.; Modarelli, D. A.; Parquette, J. R.* Amphiphilic Self-Assembly of an n-Type Nanotube. Angew. Chem. Int. Ed. 2010, 49, 7688.
Shao, H.; Parquette, J. R.* Controllable Peptide-Dendron Self-Assembly: Interconversion of Nanotubes and Fibrillar Nanostructures. Angew. Chem. Int. Ed. 2009, 48, 2525.

Shao, H.; Lockman, J. W.; Parquette, J. R.* Coupled Conformational Equilibria in β-Sheet Peptide−Dendron Conjugates. J. Am. Chem. Soc 2007, 129, 1884.

Shao, H.; Parquette, J. R.* A -conjugated hydrogel based on an Fmoc-dipeptide naphthalene diimide semiconductor. Chem. Commun. 2010, 46, 4285.

Shao, H.; Nguyen, T.; Romano, N. C.; Modarelli, D. A.; Parquette, J. R.* Self-Assembly of 1-D n-Type Nanostructures Based on Naphthalene Diimide-Appended Dipeptides. J. Am. Chem. Soc. 2009, 131, 16374.

Wu, B.; Parquette, J. R.*; RajanBabu, T. V.* Regiodivergent Ring Opening of Chiral Aziridines. Science 2009, 326, 1662.

Yu, J. F.; RajanBabu, T. V.*; Parquette, J. R.* Conformationally driven asymmetric induction of a catalytic dendrimer. J. Am. Chem. Soc. 2008, 130, 7845.