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Xiaoming (Shawn) He, Ph.D.

Xiaoming (Shawn) He, Ph.D.
Associate Professor, Department of Biomedical Engineering
The Ohio State University
Phone: (614) 292-6992
Email: xiaoming.he@osumc.edu

My lab has been focused on developing novel nano and micro scale biomaterials for cell/tissue engineering, regenerative medicine, and cancer treatment. At the nano scale, we develop nanoparticles that are responsive to environmental stimuli (e.g., temperature and pH) to encapsulate therapeutic agents for controlled and targeted delivery to improve their efficacy while minimizing their systemic toxicity. At the microscale, we fabricate small microcapsules of natural polymers with great biocompatibility to encapsulate living cells and therapeutic agents for cell-based medicine and tissue regeneration. We have also been working on developing new strategies using the micro and nanotechnologies to effectively bank cell-based medicine at not only cryogenic but ambient temperature for wide distribution and future use (just like what we are doing with pharmaceutical drug). For more information on our lab, please visit http://helab.openwetware.org/
Team Members
Wujie Zhang, Postdoc
Wei Rao, Postdoc
Jung K. Choi, Postdoc
Pranay Agarwal, PhD Student
Peter Bielecki, Undergraduate
Research Interests
Multiscale biomaterials, micorencapsulation, gene/drug delivery, and cell banking
Selected Publications
Zhang W and He X. Microencapsulating and banking living cells for cell-based medicine. Journal of Healthcare Engineering 2011; 2: 427-446

He X. Preservation of embryonic stem cells. In Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Ed: Atwood, C.; Vienna, Austria: InTech Publisher, pp113-138, 2011

He X. Thermostability of biological systems: Fundamentals, challenges, and quantification. The Open Biomedical Engineering Journal 2011; 5: 47-73

Yang G, Veres M, Szalai G, Zhang A, Xu LX, and He, X. Biotransport phenomena in freezing mammalian oocytes. Annals of Biomedical Engineering 2011; 39(1): 580-591

Zhang W, Gilstrap K, Wu L, K.C., RB, Moss MA, Wang Q, Lu X, and He X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano 2010; 4(11): 6747-6759

Yang G, Gilstrap K, Zhang A, Xu LX, and He X. Collapse temperature of solutions important for lyopreservation of living cells at ambient temperature. Biotechnology and Bioengineering 2010; 106(2): 247-259

Zhang W, Yang G, Zhang A, Xu LX, and He X. Preferential vitrification of water in small (~100 µm) alginate microcapsules significantly augments cell cryopreservation by vitrification. Biomedical Microdevices 2010; 12(1): 89-96

Zhang W and He X. Encapsulation of living cells in small (~100 µm) alginate microcapsules by electrostatic spraying: a parametric study. Journal of Biomechanical Engineering 2009; 131: Article No. 074515 (6pp)

Zhang W, Rong J, Wang Q, and He X. The encapsulation and intracellular delivery of trehalose using a thermally responsive nanocapsule. Nanotechnology 2009; 20(27): Article No. 275101 (14pp)

Li D and He, X. Desiccation induced structural alterations in a 66-amino acid fragment of an anhydrobiotic nematode late embryogenesis abundant (LEA) protein. Biomacromolecules 2009; 10: 1469-1477