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Liang Guo, PhD

Liang Guo, Ph.D.
Assistant Professor, Electrical & Computer Engineering, College of Engineering
Assistant Professor, Neuroscience, College of Medicine
Phone: (614) 292-5878
Email: guo.725@osu.edu
The goal of Dr. Guo’s laboratory is to integrate advances in tissue engineering, synthetic biology, stem cell technology, drug delivery, biomaterials, electronics, MEMS/NEMS, and neural engineering into the engineering of living devices and implants for a variety of biomedical applications. The team uses a highly interdisciplinary approach to study the engineering principles and methods for living devices. The lab specifically focuses on neural interfacing technology and biological circuits engineering as applied to neuroscience and neural prosthetics.
Team Members
Xiao Xie, Ph.D. – Postdoc
Yongchen Wang – Ph.D. student
Bingxi Yan – Ph.D. student
Yu Wu – Ph.D. student
Research Interest
Neural tissue engineering
Living device biofabrication
Synthetic biology
Neural interfacing technology
Neural prosthetics
Biotronic engineering
Biological cyber-physical systems (bioCPS)
Selected Publications
  1. Guo L, Ma M, Zhang N, Langer R, Anderson DG. Stretchable polymeric multielectrode array for conformal neural interfacing. Advanced Materials. 2014 Mar; 26(9): 1427–1433.
  2. Ma M, Guo L, Anderson DG, Langer R. Bio-inspired polymer composite actuator and generator driven by water gradients. Science. 2013 Jan; 339(6116):186–189.
  3. Guo L, Guvanasen GS, Liu X, Tuthill C, Nichols TR, DeWeerth SP. A PDMS-based integrated stretchable microelectrode array (isMEA) for neural and muscular surface interfacing. IEEE Transactions on Biomedical Circuits and Systems. 2013 Feb; 7(1): 1–10.
  4. Meacham KW, Guo L, DeWeerth SP, Hochman S. Selective stimulation of the spinal cord surface using a stretchable microelectrode array. Frontiers in Neuroengineering. 2011 Apr; 4, article 5.
  5. Guo L, DeWeerth SP. An effective lift-off method for patterning high-density gold interconnects on an elastomeric substrate. Small. 2010 Dec; 6(24): 2847–2852.
  6. Guo L, DeWeerth SP. High-density stretchable electronics: Toward an integrated multilayer composite. Advanced Materials. 2010 Sep; 22(36): 4030–4033.
  7. Guo L, Meacham KW, Hochman S, DeWeerth SP. A PDMS-based conical-well microelectrode array for surface stimulation and recording of neural tissues. IEEE Transactions on Biomedical Engineering. 2010 Oct; 57(10): 2485–2494.
  8. Desai SA, Rolston JD, Guo L, Potter SM. Improving impedance of implantable microwire multi-electrode arrays by ultrasonic electroplating of durable platinum black. Frontiers in Neuroengineering. 2010 May; 3, article 5.
  9. Meacham KW, Giuly RJ, Guo L, Hochman S, DeWeerth SP. A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord. Biomedical Microdevices. 2008 Apr; 10(2): 259–269.