Ohio State Navbar

Sign In

José Javier Otero, MD, PhD

 

Assistant Professor
Associate Director of Neuropathology
The Ohio State University College of Medicine Department of Pathology
4169 Graves Hall
333 W 10th Avenue
Columbus, OH 43210
Tel:  614-685-6799
Fax:  614-292-5849
Pager: 614-346-1811

 

 

 

The goal of the laboratory is to elucidate the mechanisms of developmental and neoplastic disorders of the central nervous system. One focus of the laboratory is the investigation of potential mechanisms of Sudden Infant Death Syndrome (SDIS)/Sudden Unexpected Death in an Infant (SUDI) using traditional approaches as well as “next gen” sequencing technology and stem cell biology. SIDS, affecting 1 in 2000 infants per year, has been challenging to study as the diagnosis is rendered to a spectrum of victims, some of which are accidental (“sporadic” SIDS) whereas others show biological etiology (“syndromic” SIDS). Within the “syndromic” SIDS spectrum, a range of pathological causes include poor ability to induce a respiratory drive (hypoventilation) and those who suffer from sudden cardiac death (cardiogenic, or Long QT-like). The ultimate goal of this work is to establish a diagnostic test to screen newborns at risk of suffering from “syndromic” SIDS. We have used a particularly severe case of central congenital hypoventilation syndrome (CCHS) as a model to study the development of CNS respiratory neurons in vitro using induced pluripotent stem cells. CCHS is caused by mutations in the gene PHOX2B and is characterized by a loss of PHOX2B expressing neurons in the brainstem.
Research Interests
Diagnostic Neuropathology (Clinical)
Clinical/translational research
Basic Research: Non-canonical functions of CCNA2
Post-natal hindbrain development
 
Selected Publications
Otero, J.J., Chang, J., Leung, M., Gokozan, H.N., Gygli, P.E., Catacutan, F.P., Czeisler,C., “Mitotic Events in Murine Cerebellar Granule Progenitor Cells that Expand Cerebellar Surface Area are Critical for Normal Cerebellar Cortical Lamination” Journal of Neuropathology and Experimental Neurology, March2015 - Volume 74 -Issue 3 - p 261–272
 
Otero,J.J., Mathsyaraja, H., Thies, K., Taffany,D.A., Deighan, C., Liu, T., Pecot, T., Yu, L., Fernandez, S.A., Shapiro, C., Timmers, C., Lustberg, M., Chalmers, J., Leone, G., Ostrowski, M.C.CA, “CSF1-ETS2 Induced microRNA in Myeloid Cells Promote Metastatic Tumor Growth” Oncogene, 2014, Sept 22 doi: 10.1038
 
JoseJ. Otero2, Mohammad Faizal Ahmad Fauzi1,5, HamzaGokozan2, Brad Elder3, Vinay Puduvalli4, Metin N. Gurcan1. Classificationof Glioblastoma and Metastasis for Neuropathology Intraoperative Diagnosis: A Multi-resolution Textural Approach to Model the Background.SPIE Medical Imaging- Digital Pathology Conference Publication (2014).
 
Otero, J.J., Ilona Kalaszczynska, Wojciech Michowski, Michael Wong, Patrick Edwin Gygli, Hamza Numan Gokozan1, Amélie Griveau, Junko Odajima4, CatherineCzeisler, Fay Patsy Catacutan, Alice Murnen, Ulrich Schüler,Piotr Sicinski, and David Rowitch,Cerebellar Cortical Lamination and Foliation RequireCyclin A2 Dev Biol. 2014 Jan 15;385(2):328-39.
 
Otero, J.J., Rao, S, DeJessus,J, Short, A., Sarkar, A., Winter, J. Glioblastoma behaviorsin 3D collagen-hyaluronan compositehydrogels. ACS AppliedMaterials and Interfaces (2013), ACS Appl Mater Interfaces. 2013 Oct 9;5(19):9276-84.
 
Fancy, SPJ, Harrington, EP, Yuen, TJ, Silbereis,JC, Zhao, C, Beranzini, SE, Bruce, CC, Otero, JJ, Huang, EC, Nusse, R, Franklin, JM, and Rowitch, DH. Axin2 as regulatory and Therapeutic Target in Newborn Brain Injury and Remyelination. Nature Neuroscience, doi:10.1038/nn.2855.
 
Otero, J.J., and Tihan, T. Morphological Analysisof CDC2 and Glycogen SynthaseKinase 3β Phosphorylation as Markers of G2->M Transition in Glioma, Pathology ResearchInternational, vol. 2011, ArticleID 216086, 19 pages, 2011. doi:10.4061/2011/216086.
 
Otero,J.J., Rowitch, D., Vandenberg, S., OLIG2 is Differentially Expressedin Pediatric
Astrocytic and in EpendymalNeoplasms. Journal of Neuro-oncology, 2010epub.
 
Otero JJ, Han SJ, Yang I, Ahn BJ, Tihan T, McDermott MW, Berger MS, Prados MD, Parsa AT. Clinical characteristics and outcomes for a modern series of primary gliosarcoma patients. Cancer 2010;116(5):1358-66.
 
Otero, J.J., Han, S, Yang, I, Ahn, B, Tihan, T, McDermott, M, Berger, Prados,M, Secondary Gliosarcoma After Diagnosis of Glioblastoma: Clinical experience with thirty consecutive patients. Journalof Neurosurgery, 2010;112(5):990-6.
  
Otero, J.J.*, Guddati,A.K.*, Kessler E, Aistrup, G., Wasserstrom, A., Han, X., Webber, M., Stupp, S., Lomasney, J, and Kessler,J.A. Embryonic Stem Cells Overexpressing Pitx2c Engraft in Infarcted Myocardium and Improve Cardiac Function.(2009) International Heart Journal, vol. 50 (6): 783-799.
 
*Indicates equal authorship contribution to the work.
 
Otero J.J., Fu W., Kan L., Cuadra A.E., and Kessler J.A. Beta-cateninsignaling is required for neural differentiation of embryonic stem cells. Development (2004) vol 131 (15): 3545-3557.