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Sashwati Roy, PhD

Sashwati Roy, PhD
Associate Professor, Department of Surgery,
Director, Laser Capture Molecular Core, The Ohio State University
Phone: (614) 247-7657
Email: Sashwati.roy@osumc.edu

Primary focus of our laboratory is to study significance and mechanisms of resolution of inflammation in the tissue repair and regeneration. Specifically we are interested in the role of macrophages in resolution of inflammation during pathological tissue repair such as diabetic wound healing. We use state of the art technologies such as laser capture microdissection and microarray expression (mRNA and miRNA) profiling to address these research questions.
Team Members
Dr. Kasturi Ganesh, Post Doctoral Fellow
Amitava Das, Graduate Research Assistant
Ryan Dickerson, Research Assistant
Jennifer Mele, Research Assistant, LCM Core
Bhakti Deshpande, Research Aide, LCM Core
Motaz Abas, Student Research Assistant
Tykie Theofilos, Student Research Assistant
Research Interests
Chronic wound Inflammation
Resolution of Inflammation
Wound macrophages
Cell based therapy
miRNA in innate immune responses
Selected Publications
Roy S, Patel D, Khanna S, Gordillo G, Biswas S, Friedman A, Sen CK. (2007) Genome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue. PNAS 104(36):14472-7.

Roy S, Sen CK. miRNA in wound inflammation and angiogenesis. Microcirculation. 2011 Dec 28. [Epub ahead of print]

Roy S, Sen CK. MiRNA in innate immune responses: novel players in wound inflammation. Physiol Genomics. 2011 May 1;43(10):557-65. Epub 2010 Dec 7.

Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S (2010) Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 5: e9539. PMCID: PMC2832020.

Chan YC, Khanna S, Roy S, and Sen CK. miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J Biol Chem 286: 2047-2056, 2011.

Roy S, Dickerson R, Khanna S, Collard E, Gnyawali U, Gordillo GM, Sen CK. Particulate b-glucan induces TNF-a production in wound macrophages via a redox-sensitive NF-kb-dependent pathway. Wound Repair Regen. 2011 May;19(3):411-9. Epub 2011 Apr 21. (PMCID in progress).

Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, et al. (2010) Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc Natl Acad Sci U S A 107: 6976-6981. PMCID: PMC2872456.

Collard E, Roy S. (2010) Improved function of diabetic wound-site macrophages and accelerated wound closure in response to oral supplementation of a fermented papaya preparation. Antioxid Redox Signal. 13(5):599-606. PMCID: PMC2935338.

Sen CK, Gordillo GM, Khanna S, Roy S. Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res. 2009;46(6):527-40. PMCID: PMC2803349.

Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. (2009)  MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res. 2009 Apr 1;82(1):21-9. Epub 2009 Jan 15. PMCID: PMC2652741.

Shilo S, Roy S, Khanna S, Sen CK (2008).Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells. Arterioscler Thromb Vasc Biol. 28(3):471.

Roy S, Khanna S, Rink C, Biswas S, Sen CK. Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome. Physiol Genomics. 2008 Jul 15; 34(2):162-84. PMCID: PMC2494843.